ABSTRACT
Giant cell tumour (GCT) of the small bones is relatively uncommon tumour. It occurs most commonly in the distal portions of femur and radius and proximal end of tibia. GCT of small bones presents at advanced stages with major bony destruction. These tumours represent more aggressive course; associated with increased local recurrence rates (40%) and metastasis. Various treatment modalities like en-bloc resection, cryosurgery, intralesional curettage with burring/phenolization or bone cement are available. In our case en-bloc resection with reconstruction using nonvascular autogenous fibular strut graft was used in patient of 2nd metatarsal GCT and a favourable functional outcome was observed.
Subject(s)
Bone Neoplasms/surgery , Bone Transplantation/methods , Fibula/transplantation , Giant Cell Tumor of Bone/surgery , Metatarsal Bones , Osteotomy/methods , Autografts , Humans , MaleABSTRACT
Several recent reports have described "atypical" fractures of the subtrochanteric and diaphyseal femoral shaft that occur with minimal or no trauma, associated with the use of bisphosphonates. Physicians treating bone diseases with bisphosphonate need, therefore, to be aware of this potential risk and plan the prophylaxis, early diagnosis and prevention of potential consequences. We review the literature on this newly described complication, with particular focus on pathogenesis, preventive measures suggested before and during therapy with bisphosphonates, and the most frequent clinical presentation of these lesions. The recommendations for the management and care of patients who are on long-term use of alendronate (bisphosphonates) are summarized.
