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1.
Horiz. sanitario (en linea) ; 19(3): 365-373, sep.-dic. 2020. tab
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1154334

ABSTRACT

Resumen Objetivo: Determinar la frecuencia de sintomatología depresiva y su tratamiento en personas adultas mayores, afiliadas a las instituciones de seguridad social de salud en México. Material y métodos: Estudio descriptivo transversal con 3,114 participantes de 7 estados del país, los cuales fueron evaluados psicológicamente, empleando la Escala de Depresión Geriátrica (GDS) de Yesavage, también se analizó su afiliación a seguridad social, funcionalidad (índices Barthel y Lawton) y estado cognoscitivo (Minimental de Folstein). El análisis de la información se realizó empleando el paquete estadístico SPSS (Statistical Package for the Social Sciences), así como los datos sociodemográficos de los participantes. Resultados: Se observó cobertura en el 88.5% de la población. La prevalencia de depresión es del 27.4% y el 96.8% de ellos no recibe tratamiento, además el 18.9% presenta dependencia funcional, el 16.2% deterioro cognoscitivo y el 7.4% ha sufrido al menos una caída con lesiones. Únicamente el 11.2% del total de enfermos fue diagnosticado en su clínica. Conclusión: La prevalencia de depresión no tratada en adultos mayores con acceso a servicios de salud es altamente significativa, es urgente la generación de protocolos, programas y capacitación de profesionales de salud que permitan identificar la patología y atender de manera integral a dicho grupo etario.


Abstract Objective: to determine the frequency of depressive symptoms and their treatment in older adults affiliated to the social health security institutions in Mexico. Material and methods: a descriptive cross-sectional study with 3,114 participants from 7 states of the country who were psychologically evaluated using the Geriatric Depression Scale (GDS) by Yesavage, also analyzed their affiliation to social security, functionality (Barthel and Lawton index) and cognitive status (Minimental State Examination of Folstein). The analysis of the information was carried out using the statistical package SPSS (Statistical Package for the Social Sciences) as well as the sociodemographic data of the participants. Results: Coverage was observed in 88.5% of the population. Prevalence of depression was 27.4% and 96.8% of them did not receive treatment. In addition 18.9% had functional dependence, 16.2% had cognitive impairment and 7.4% had suffered at least one fall with injuries. Only 11.2% of all participants were diagnosed in their clinic. Conclusion: The prevalence of untreated depression in older adults with access to health services is highly significant. It is urgent the generation of protocols, programs and training of health professionals that allow to identify the pathology and provide comprehensive care for that age group.


Sumário Objetivo: determinar a frequência dos sintomas depressivos e seu tratamento em idosos afiliados às instituições de saúde previdenciária do México. Material e métodos: estudo descritivo transversal com 3.114 participantes de 7 estados do país, avaliados psicologicamente pela Escala de Depressão Geriátrica Yesavage {GDS}, analisando também sua afiliação à seguridade social, funcionalidade (índices de Barthel e Lawton) e estado cognitivo. (Minimental de Folstein). A análise das informações foi realizada no programa estatístico SPSS (Statistical Package for the Social Sciences), além dos dados sociodemográficos dos participantes. Resultados: A cobertura foi observada em 88,5% da população. A prevalência de depressão é de 27,4% e 96,8% deles não recebem tratamento; além disso, 18,9% possuem dependência funcional, 16,2% comprometimento cognitivo e 7,4% sofreram pelo menos uma queda com lesões. Apenas 11,2% de todos os pacientes foram diagnosticados em sua clínica. Conclusão: A prevalência de depressão não tratada em idosos com acesso a serviços de saúde é altamente significativa, é urgente a geração de protocolos, programas e treinamento de profissionais de saúde para identificar a patologia e prestar assistência integral a essa faixa etária.


Résumé Objectif: Déterminer la fréquence de la symptomatologie dépressive et de son traitement chez les personnes âgées affiliées aux institutions de santé de la sécurité sociale au Mexique. Matériel et méthodes: Étude descriptive transversale avec 3 114 participants de 7 états du pays, évalués psychologiquement avec l'échelle de dépression gériatrique de Yesavage (GDS). Leur affiliation à la sécurité sociale, leur fonctionnalité (indices de Barthel et Lawton) et leur état cognitif (Folstein Minimal) ont également été évalués. L'analyse de ces informations, ainsi que des données sociodémographiques des participants, a été réalisée à l'aide du logiciel statistique SPSS (Statistical Package for the Social Sciences). Résultats: La couverture sociale a été observée chez 88,5 % de la population. La prévalence de la dépression est de 27,4% et 96,8% d'entre eux ne reçoivent pas de traitement. De plus, 18,9% présentent une dépendance fonctionnelle, 16,2% une déficience cognitive et 7,4% ont fait au moins une chute avec blessures. Seulement 11,2 % du nombre total des participants ayant une dépression ont été diagnostiqués dans leur clinique. Conclusion: La prévalence de la dépression non traitée chez les personnes âgées ayant accès aux services de santé est très importante. Il est urgent de générer des protocoles, des programmes et des formations pour les professionnels de santé qui permettent d'identifier la pathologie et de fournir une attention globale pour cette tranche d'âge.

2.
Gac Med Mex ; 153(7): 794-799, 2017.
Article in English | MEDLINE | ID: mdl-29414970

ABSTRACT

OBJECTIVE AND METHODS: Diabetes mellitus (DM) is a global health problem, which significantly affects older adults. . The prevalence and biopsychosocial conditions of DM in older adults in the State of Hidalgo, Mexico, are analyzed using the Health and Aging Survey 2014 (SABE-Hidalgo, Mexico). RESULTS: DM in older adults presents a prevalence of 28.22% in the State, predominating in women and becoming more common with increasing age. The highest frequency occurs in residents of urban areas (57.2%), those with less schooling (79.6%), and those who live with relatives (77%). In addition, 54.7% of older adults with DM had cognitive impairment, 67.9% had arterial hypertension and 45.28% presented joint disease. 41.2% suffered falls, 68.52% visual problems and 87.3% tooth loss. Finally, 85.8% receive care but only 29.2% perceive improvement in their health. CONCLUSIONS: It is fundamental to develop integral programs and policies to care for older adults with DM.


Subject(s)
Diabetes Mellitus/epidemiology , Accidental Falls/statistics & numerical data , Age Distribution , Aged , Educational Status , Eye Diseases/epidemiology , Female , Health Surveys , Humans , Hypertension/epidemiology , Joint Diseases/epidemiology , Male , Mexico/epidemiology , Prevalence , Residence Characteristics , Sex Distribution , Tooth Loss/epidemiology , Urban Population/statistics & numerical data
3.
J Gen Virol ; 90(Pt 12): 2893-2901, 2009 Dec.
Article in English | MEDLINE | ID: mdl-19692542

ABSTRACT

The 3' untranslated region (3'UTR) of the dengue virus (DENV) genome contain several sequences required for translation, replication and cyclization processes. This region also binds cellular proteins such as La, polypyrimidine tract-binding protein (PTB), Y box-binding protein 1, poly(A)-binding protein and the translation initiation factor eEF-1 alpha. PTB is a cellular protein that interacts with the regulatory sequences of positive-strand RNA viruses such as several picornaviruses and hepatitis C virus. In the present report, it was demonstrated that PTB translocates from the nucleus to the cytoplasm during DENV infection. At 48 h post-infection, PTB, as well as the DENV proteins NS1 and NS3, were found to co-localize with the endoplasmic reticulum marker calnexin. Silencing of PTB expression inhibited virus translation and replication, whilst overexpression of PTB augmented these processes. Thus, these results provide evidence that, during infection, PTB moves from the nucleus to the cytoplasm and plays an important role in the DENV replicative cycle.


Subject(s)
Cytoplasm/metabolism , Dengue Virus/pathogenicity , Polypyrimidine Tract-Binding Protein/metabolism , Animals , Cell Line, Tumor , Cell Nucleus/metabolism , Chlorocebus aethiops , Dengue Virus/genetics , Dengue Virus/physiology , Humans , Polypyrimidine Tract-Binding Protein/genetics , Vero Cells , Viral Nonstructural Proteins/genetics , Viral Nonstructural Proteins/metabolism , Virus Replication
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