ABSTRACT
We evaluated adherence to HIV treatments every 4 months during one year in 63 HIV-infected subjects using combination therapies including a protease inhibitor. A total of 18 subjects reported a high level of adherence, 14 in two evaluations, and eight a low level of adherence in all the three evaluations. The remaining 23 subjects (36.5%) reported different levels of adherence to treatment in the three evaluations. These findings suggest that the level of adherence to treatment changes markedly for each patient over time.
Subject(s)
HIV Infections/drug therapy , HIV Protease Inhibitors/therapeutic use , Patient Compliance , Adolescent , Adult , CD4-Positive T-Lymphocytes , Cross-Sectional Studies , Drug Therapy, Combination , Female , Follow-Up Studies , HIV Infections/psychology , Humans , Lymphocyte Count , Male , Surveys and Questionnaires , Viral LoadABSTRACT
The controlled, open, cross-over study reported in this article demonstrates that sotalol and propranolol administered twice daily to 20 patients provide an equally satisfactory control of moderately elevated blood-pressure for 24 hours. The average daily dose of sotalol and propranolol required to achieve this effect was 200 +/- 95 mg and 154 +/- 90 mg respectively. No important side-effects were observed.
Subject(s)
Hypertension/drug therapy , Propranolol/therapeutic use , Sotalol/therapeutic use , Adult , Blood Pressure/drug effects , Drug Evaluation , Female , Heart Rate/drug effects , Humans , Hypertension/blood , Male , Middle Aged , Propranolol/adverse effects , Sotalol/adverse effects , Time FactorsABSTRACT
To evaluate the hypotensive efficacy of labetalol (600 mg/day) six mild to moderate hypertensive patients were studied by the indirect continuous blood pressure monitoring with the Del Mar Avionics Pressurometer 111 degrees. This technique gives a much larger number of blood pressure values in a greater variety of conditions than the conventional Riva-Rocci sphygmomanometer. After one month of continuous therapy there was a substantial reduction in systolic and diastolic pressure. The increased index of Kurtosis revealed a decreased blood pressure variability. The circadian changes of blood pressure were not significantly affected, but the morning peak was smoothed by labetalol.
