Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
J Mycol Med ; 34(1): 101464, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38367460

ABSTRACT

INTRODUCTION: The cases of dermatophytosis are increasing and they are associated with a higher number of therapeutic failures leading the doctor to prescribe combinations of antifungals as therapy. The objective was to evaluate the interaction of terbinafine and ciclopirox, the most commonly antifungals used in the clinic, in dermatophyte isolates. METHODOLOGY: The minimum inhibitory concentrations (MIC) of ciclopirox and terbinafine were determined by the broth microdilution method according CLSI and the checkerboard assay was used to evaluate the interaction between the antifungal agents. RESULTS: For terbinafine the mic50 was 0.125 ug/mL and mic90 was 0.250 ug/mL. For ciclopirox the values were 2.0 ug/mL for mic50 and 4.0 ug/mL for mic90. No synergistic interaction was observed for the dermatophyte isolates tested. CONCLUSION: These results suggest that the use of terbinafine in combination with ciclopirox, which is widely used in the clinic, may not be a good choice for the treatment of onychomycosis.


Subject(s)
Antifungal Agents , Onychomycosis , Humans , Terbinafine/pharmacology , Terbinafine/therapeutic use , Ciclopirox/therapeutic use , Antifungal Agents/pharmacology , Antifungal Agents/therapeutic use , Naphthalenes/pharmacology , Naphthalenes/therapeutic use , Onychomycosis/drug therapy , Onychomycosis/microbiology , Microbial Sensitivity Tests
SELECTION OF CITATIONS
SEARCH DETAIL
...