Who drive the health policy agenda in India? Actors in National Health Committees since Independence.

Introduction: Health policies reflect the ideas and interests of the actors involved. The Indian Government constituted many health committees for policy recommendations on myriad issues concerning public health, ranging from tribal health to drug regulation. However, little is known about their composition and backgrounds. We reviewed these committees to map the actors and institutions. Methods: We elicited information on all relevant health committees available in the public domain. All were constituted post-independence, except two, with recommendations that remain pertinent to date. Data for chairpersons and members - their professions, gender, institutions, and location were extracted and analysed. Reliable online sources were used to collate the information. Results: We identified 23 national health committees from 1943 to 2020 with available reports. There were 25 chairpersons and 316 members. All except three chairpersons were men. Among members, only 11% were women. The majority (51%) had experience working in health systems; however, most were medical doctors, with negligible representation of other cadres. We noted the centralization of location, with 44% of members based in the national capital of Delhi. Government administrators were maximally represented (55%), followed by medical academia (19%). Post-2000, we have observed slightly improved diversity across some parameters like gender (15% women vs 9% earlier) and affiliation. However, the centralization of the location to the national capital had increased (55% post-2000 vs. 39% pre-2000). Conclusion: Indian health committees lack diversity in representation from multiple perspectives. Henceforth, health policymakers should prioritize including diverse social, geographical, and health systems actors to ensure equitable policymaking.

Giving volume to the elephant in the imaging room.

Rudolf Virchow, the founder of cellular pathology, held that even when physical or chemical investigations yield the laws of physiology or medicine, the anatomist can still proudly state: This is the structure in which the law becomes manifest. In his words, "physiology presupposes anatomy." Pathological anatomy studies, at usual microstructural scales (approximately 1-100 µm), via light microscopic 2D histology, provided many insights into structure-function relationships of health and disease. For example, such studies established the progression of granulomas, bronchial erosions, microcavities, and destructive lung disease in tuberculosis. While histologic studies remain the cornerstone of such efforts, the advent of nano or micro-X-ray computed tomography (n/µCT) has now made it additionally possible to obtain 3D visualizations of soft and hard tissues, while preserving the tissue for additional investigations. This has applications for old as well as new diseases (Katsamenis et al, 2019; Tanabe & Hirai, 2021).

Enhanced central histaminergic transmission attenuates compulsive-like behavior in mice.

Present investigation demonstrated the effect of central histaminergic transmission on the compulsive-like marble burying and spontaneous alteration behavior (SAB) in mice. Result demonstrates that on enhancement of endogenous histaminergic transmission in mice achieved by central (i.c.v.) administration of histamine or central histamine neuronal releaser, H3 receptor antagonist or on intraperitoneal (i.p.) administration of histamine precursor, l-histidine significantly attenuated the number of marble buried in marble burying behavior (MBB) test as well as obliterated the persistent behavior induced by 5-HT1A receptor agonist, 8-OH-DPAT in T-Maze test. Furthermore, central injection of histamine H1 receptor agonist, FMPH or H2 receptors agonist, amthamine also attenuated the MBB in mice. On the other hand, prior i.c.v administration of H1 but not H2 receptor antagonist attenuated the effects exhibited in MBB test on mice by all the above agents capable of enhancing the endogenous central histaminergic transmission. Thus, the results of the present investigation delineate the attenuating effect of central histaminergic transmission predominantly via H1 receptor on compulsive-like behavior in mice.