ABSTRACT
Pleomorphic xanthoastrocytoma (PXA) is a low-grade glioma comprising 1% of all astrocytomas with an extremely rare anaplastic counterpart usually found in young adults. These tumors are most often cerebral in origin and their presentation in the elderly signifies poor prognosis. As these tumors are an important differential of glioblastoma, diagnosing them accurately is essential for management. We present a 68-year-male with positive cerebellar signs and clinico-radiological impression of cerebellar metastatic deposits, subsequently diagnosed as cerebellar PXA with anaplastic features. The case in discussion is unique in its age, site, and grade of presentation, with key histological features rebuking the clinical and radiological diagnosis of metastasis. The rarity and ambiguous management protocol of these tumors make their documentation an important addition to the existing literature with emphasis on possibility of late presentation and at sites other than the cerebrum.
Subject(s)
Astrocytoma , Brain Neoplasms , Glioblastoma , Glioma , Young Adult , Male , Humans , Aged , Brain Neoplasms/diagnostic imaging , Brain Neoplasms/pathology , Astrocytoma/diagnostic imaging , Astrocytoma/pathology , Glioblastoma/pathologySubject(s)
Adenocarcinoma/diagnostic imaging , Ear Canal/pathology , Ear Neoplasms/diagnostic imaging , Sweat Gland Neoplasms/diagnostic imaging , Adenocarcinoma/secondary , Adult , Chondroma/diagnosis , Diagnosis, Differential , Ear Canal/diagnostic imaging , Ear Neoplasms/secondary , Female , Histological Techniques , Humans , Sweat Gland Neoplasms/pathology , Tomography, X-Ray ComputedABSTRACT
Extrapulmonary tuberculosis coexistent with lymphomas in the same organ are rare and have been reported in the literature. The most common organs that are involved are small bowel, bronchus, kidney, and lymph nodes. Interestingly, the lymphoma that is commonly present with extrapulmonary tuberculosis is Hodgkin's lymphoma followed by low-grade non-Hodgkin's lymphoma. In the present study, we report a 60-year-old man with complaints of fever, loss of appetite, and generalized weakness. On investigation, generalized lymphadenopathy was noted, and the biopsy of cervical lymph node revealed coexistence of diffuse large B-cell lymphoma with extrapulmonary tuberculosis. This case is the second reported case of diffuse large B-cell lymphoma with extrapulmonary tuberculosis in the world and the first in India.
