1.
Antiviral Res
; 85(3): 562-5, 2010 Mar.
Article
in English
| MEDLINE
| ID: mdl-20064563
ABSTRACT
A new bioactive diterpene skeleton resulting from a backbone rearrangement is described. Activity of the rearranged product and several derivatives against Herpes Virus Simplex type 2 is reported.
Subject(s)
Antiviral Agents/chemical synthesis , Antiviral Agents/pharmacology , Diterpenes/chemical synthesis , Diterpenes/pharmacology , Herpesvirus 2, Human/drug effects , Animals , Chlorocebus aethiops , Inhibitory Concentration 50 , Molecular Structure , Vero Cells , Viral Plaque Assay , Virus Replication/drug effects
2.
Eur J Med Chem
; 45(2): 811-6, 2010 Feb.
Article
in English
| MEDLINE
| ID: mdl-19892441
ABSTRACT
A series of C18-oxygenated derivatives of dehydroabietic acid were synthesized from commercial abietic acid and evaluated for their cytotoxic, antimycotic, and antiviral activities.
Subject(s)
Abietanes/chemistry , Abietanes/pharmacology , Abietanes/chemical synthesis , Animals , Antifungal Agents/chemical synthesis , Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Antineoplastic Agents/chemical synthesis , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Antiviral Agents/chemical synthesis , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , Cell Line, Tumor , Fungi/drug effects , Herpesvirus 1, Human/drug effects , Humans , Hydrophobic and Hydrophilic Interactions , Inhibitory Concentration 50 , Microbial Sensitivity Tests
3.
Eur J Med Chem
; 44(6): 2468-72, 2009 Jun.
Article
in English
| MEDLINE
| ID: mdl-19217699
ABSTRACT
A series of C18-oxygenated derivatives of abietic acid were synthesized and evaluated for their cytotoxic, antimycotic, and antiviral activities. In general, the introduction of an aldehyde group at C18 did improve the resultant bioactivity, while the presence of an acid or alcohol led to less active compounds.
