ABSTRACT
The congenital deficit of FVII of coagulation it's an anomaly of genetic transmission autosomal recessive type, it can occur with clinical manifestations like hematomas and spontaneous bleeding or not. The normal levels of FVII it's found between 70%-130% of the laboratory reference value. For unknown reasons there is a poor correlation between levels of FVII and bleeding risk. During pregnancy coagulation can be significantly altered, there is a no clear consensus and a very few information about how to act during labor in a patient with a FVII deficit. The case of a 35-year-old patient with 35 weeks of gestation and congenital deficit of the coagulation FVII (36%) is presented, epidural analgesia is performed during labor previously administering activated recombinant FVII (rFVIIa) without complications (Spinal hematoma, postpartum bleeding, thrombosis).
Subject(s)
Analgesia, Epidural , Factor VII Deficiency , Postpartum Hemorrhage , Thrombosis , Adult , Blood Coagulation , Factor VII Deficiency/complications , Factor VII Deficiency/genetics , Female , Humans , Pregnancy , Thrombosis/complicationsABSTRACT
El déficit congénito del factor VII (FVII) de la coagulación es una anomalía de transmisión genética de tipo autosómico recesivo, puede presentarse con manifestaciones clínicas como hematomas y sangrados espontáneos o no. Los niveles normales del FVII se encuentran entre el 70-130% del valor de referencia del laboratorio. Por razones desconocidas existe una pobre correlación entre los niveles del FVII y el riesgo de sangrado. Durante el embarazo se puede alterar notablemente la coagulación, no existe un consenso claro y hay escasa información sobre cómo actuar durante el trabajo de parto en paciente con déficit del FVII. Se presenta el caso de una mujer de 35 años en la semana 35 de gestación y déficit congénito del FVII (36%), se realiza analgesia peridural durante el parto administrando previamente factor VII recombinante activado (rFVIIa) sin complicaciones (hematoma peridural, sangrado posparto, trombosis).(AU)
The congenital deficit of FVII of coagulation it's an anomaly of genetic transmission autosomal recessive type, it can occur with clinical manifestations like hematomas and spontaneous bleeding or not. The normal levels of FVII it's found between 70%-130% of the laboratory reference value. For unknown reasons there is a poor correlation between levels of FVII and bleeding risk. During pregnancy coagulation can be significantly altered, there is a no clear consensus and a very few information about how to act during labor in a patient with a FVII deficit. The case of a 35-year-old patient with 35 weeks of gestation and congenital deficit of the coagulation FVII (36%) is presented, epidural analgesia is performed during labor previously administering activated recombinant FVII (rFVIIa) without complications (Spinal hematoma, postpartum bleeding, thrombosis).(AU)
Subject(s)
Humans , Female , Adult , Analgesia, Epidural , Pregnant Women , Factor VII Deficiency , Hemorrhagic Disorders , Genetic Diseases, Inborn , Cardiopulmonary Resuscitation , AnesthesiologyABSTRACT
The congenital deficit of FVII of coagulation it's an anomaly of genetic transmission autosomal recessive type, it can occur with clinical manifestations like hematomas and spontaneous bleeding or not. The normal levels of FVII it's found between 70%-130% of the laboratory reference value. For unknown reasons there is a poor correlation between levels of FVII and bleeding risk. During pregnancy coagulation can be significantly altered, there is a no clear consensus and a very few information about how to act during labor in a patient with a FVII deficit. The case of a 35-year-old patient with 35 weeks of gestation and congenital deficit of the coagulation FVII (36%) is presented, epidural analgesia is performed during labor previously administering activated recombinant FVII (rFVIIa) without complications (Spinal hematoma, postpartum bleeding, thrombosis).
ABSTRACT
Analizamos en este artículo las normas fundamentales para la prevención de las punciones accidentales por parte de los trabajadores sanitarios, así como los pasos a seguir una vez que se ha producido la punción accidental
In the current paper we have assessed the main guidelines for prevention of accidental puntures by helthcare workers as well s the recommended steps to follow once the punture has occurred
Subject(s)
Female , Humans , Male , Punctures/adverse effects , Punctures , Blood-Borne Pathogens/isolation & purification , Contact Tracing/instrumentation , Contact Tracing/methods , Preventive Health Services/classification , Preventive Health Services , Punctures/instrumentation , Punctures/nursing , Blood-Borne Pathogens/classification , Contact Tracing/legislation & jurisprudence , Contact Tracing , Preventive Health Services/methods , Preventive Health Services/supply & distributionSubject(s)
Amino Acid Substitution , Anesthetics, Inhalation , Folic Acid Antagonists , Hyperhomocysteinemia/prevention & control , Intraoperative Complications/prevention & control , Methylenetetrahydrofolate Reductase (NADPH2)/genetics , Mutation, Missense , Nitrous Oxide , Point Mutation , Thromboembolism/prevention & control , Anesthesia, Local , Anticoagulants/therapeutic use , Antihypertensive Agents/therapeutic use , Contraindications , Folic Acid/blood , Genetic Predisposition to Disease , Heparin, Low-Molecular-Weight/therapeutic use , Homocysteine/blood , Hot Temperature , Humans , Hyperhomocysteinemia/complications , Hyperhomocysteinemia/genetics , Methylenetetrahydrofolate Reductase (NADPH2)/chemistry , Postoperative Complications/prevention & control , Preoperative Care , Protein Denaturation , Thromboembolism/etiology , Thrombophilia/geneticsABSTRACT
No disponible
Subject(s)
Humans , Amino Acid Substitution , Anesthetics, Inhalation , Hyperhomocysteinemia/prevention & control , Intraoperative Complications/prevention & control , Methylenetetrahydrofolate Reductase (NADPH2)/genetics , Mutation, Missense , Point Mutation , Thromboembolism/prevention & control , Folic Acid Antagonists , Nitrous Oxide , Anesthesia, Local , Anticoagulants/therapeutic use , Antihypertensive Agents/therapeutic use , Genetic Predisposition to Disease , Hot Temperature , Heparin, Low-Molecular-Weight/therapeutic use , Homocysteine/blood , Hyperhomocysteinemia/complications , Hyperhomocysteinemia/genetics , Methylenetetrahydrofolate Reductase (NADPH2)/chemistry , Postoperative Complications/prevention & control , Preoperative Care , Protein Denaturation , Thromboembolism/etiology , Thrombophilia/genetics , Folic Acid/bloodSubject(s)
Anesthesia, Epidural , Anticoagulants/adverse effects , Hematoma/prevention & control , Intraoperative Complications/prevention & control , Postoperative Hemorrhage/prevention & control , Practice Guidelines as Topic , Anticoagulants/administration & dosage , Anticoagulants/therapeutic use , Blood Coagulation Tests , Factor Xa Inhibitors , Flurbiprofen/administration & dosage , Heart Diseases/complications , Humans , International Normalized Ratio , Plasma , Postoperative Complications/prevention & control , Premedication/adverse effects , Thromboembolism/prevention & controlABSTRACT
No disponible
Subject(s)
Humans , Anesthesia, Epidural , Anticoagulants/adverse effects , Anticoagulants/therapeutic use , Hematoma/prevention & control , Intraoperative Complications/prevention & control , Postoperative Hemorrhage/prevention & control , Professional Practice/standards , Anticoagulants/administration & dosage , Factor Xa/antagonists & inhibitors , Flurbiprofen/administration & dosage , Heart Diseases/complications , International Normalized Ratio , Plasma , Postoperative Complications/prevention & control , Premedication/adverse effects , Thromboembolism/prevention & control , Blood Coagulation TestsABSTRACT
No disponible
Subject(s)
Humans , Injections, Subcutaneous , Vitamin B 12 , Vitamin B 12 DeficiencyABSTRACT
No disponible
Subject(s)
Female , Humans , Adult , Drug Monitoring , Antithrombin III , Contraceptives, OralABSTRACT
No disponible
Subject(s)
Aged , Male , Humans , Thrombocytopenia , Autoimmune Diseases , Anemia, Pernicious , HypothyroidismABSTRACT
No disponible
Subject(s)
Female , Humans , Risk Factors , Venous Thrombosis , Contraceptives, OralABSTRACT
No disponible
Subject(s)
Child , Child, Preschool , Adult , Infant , Female , Humans , Spain , Risk Factors , Caregivers , Parents , Patient Compliance , Primary Health Care , Venous Thrombosis , Thrombophilia , Anti-Bacterial Agents , Cross-Sectional Studies , Contraceptives, OralABSTRACT
BACKGROUND: Findings of prolonged activated partial thromboplastin time (APTT) and lupus anticoagulant are rare in asymptomatic children and are often preceded by certain types of surgery. Clinical behaviour is usually favorable. PATIENTS AND METHODS: We assessed the biological and clinical features of antiphospholipid antibodies found in 13 children diagnosed between January 1996 and September 2000 (mean age at diagnosis: 5 years). The patients were prospectively followed-up for a median of 16 months (range: 15-60). The diagnosis of lupus anticoagulant was based on the guidelines of the International Society of Thrombosis and Hematosis and included coagulation-based assays as well as enzyme-linked immunosorbent assay for anticardiolipin and anti-beta 2 glycoprotein I. RESULTS: In all patients lupus anticoagulant was detected after investigation of prolonged APTT prior to surgery (adenoidectomy in eight patients, orchidopexy in one and eye surgery in one). The antibody was associated with infectious mononucleosis in one patient and was detected during routine laboratory investigations in two. All antibodies were primary and 53.6% of events were transient. In all patients lupus anticoagulant IgG and anti-beta 2 glycoprotein I were negative. Slightly reduced factor XII:C plasma concentrations (mean: 38.2 UI/dl) were found in 30.7% of the patients. No clinical manifestations of antiphospholipid symptoms were associated with the diagnosis of antiphospholipid antibodies and none of the patients experienced bleeding after surgery. CONCLUSIONS: Primary antiphospholipid antibodies were infrequent in asymptomatic pediatric patients and were typically associated with certain types of surgery (adenoidectomy, tonsillectomy) or viral infections. They were usually transient and clinically irrelevant. These antibodies may be associated with slightly reduced plasma concentrations of factor XII and consequently a differential diagnosis with a mild factor XII deficiency should be considered.
