Plasma Lipidomics Profiles Highlight the Associations of the Dual Antioxidant/Pro-oxidant Molecules Sphingomyelin and Phosphatidylcholine with Subclinical Atherosclerosis in Patients with Type 1 Diabetes.

Here, we report on our study of plasma lipidomics profiles of patients with type 1 diabetes (T1DM) and explore potential associations. One hundred and seven patients with T1DM were consecutively recruited. Ultrasound imaging of peripheral arteries was performed using a high image resolution B-mode ultrasound system. Untargeted lipidomics analysis was performed using UHPLC coupled to qTOF/MS. The associations were evaluated using machine learning algorithms. SM(32:2) and ether lipid species (PC(O-30:1)/PC(P-30:0)) were significantly and positively associated with subclinical atherosclerosis (SA). This association was further confirmed in patients with overweight/obesity (specifically with SM(40:2)). A negative association between SA and lysophosphatidylcholine species was found among lean subjects. Phosphatidylcholines (PC(40:6) and PC(36:6)) and cholesterol esters (ChoE(20:5)) were associated positively with intima-media thickness both in subjects with and without overweight/obesity. In summary, the plasma antioxidant molecules SM and PC differed according to the presence of SA and/or overweight status in patients with T1DM. This is the first study showing the associations in T1DM, and the findings may be useful in the targeting of a personalized approach aimed at preventing cardiovascular disease in these patients.

Dydrogesterone after 60 years: a glance at the safety profile.

OBJECTIVE: To provide an evidence-based safety and tolerability overview of dydrogesterone under various progesterone-deficient conditions as a commemoration of its role in managing women's reproductive health over the past 60 years. METHODS: To identify relevant publications, we used a semi-systematic approach, which included performing a structured search through the PubMed and Cochrane central databases as well as an unstructured search for publications published in English from 2010 onward with human clinical data. RESULTS: A total of 32 relevant clinical studies were identified. Results were reported in the context of overall adverse events (AEs) and segregated according to various progesterone-deficient conditions. AEs concerning breasts (breast cancer risk), the endometrium (endometrial cancer risk), venous thromboembolism risk, and cardiovascular risk were found to be minimal when dydrogesterone was used as part of a menopausal hormone therapy regimen lasting ≤260 weeks. Vagina-related AEs, such as bleeding, discharge, irritation, and difficult coitus, occurred less frequently with dydrogesterone when used as luteal phase support in the context of assisted reproductive techniques (ARTs). However, other common AEs, such as headache, dizziness, abdominal pain, flatulence, and nausea, occurred more frequently with dydrogesterone. No maternal complications or congenital anomalies could be linked to dydrogesterone usage during ARTs or during early pregnancy to prevent recurrent miscarriages. Studies on dydrogesterone in endometriosis and premenstrual syndrome remain scarce. CONCLUSIONS: Post-approval, dydrogesterone has displayed a favorable safety and tolerability profile during its 60-year use, which is reassuring, considering its important role in managing women's reproductive health.

Fertilidad de Ovinos de pelo en el tropico de Santa Cruz / Fertility of hairy ovines in the tropic of Santa Cruz

El Objetivo principal del trabajo fue la evaluacion de la reproduccion de los genotipos de ovinos tropicales dentro de un cruzamiento absorbente de ovejas criollas de lana y reproductoras de pelo de las razas Katadhin y San Javierino, a travez del CIAT y la MBAT, en la zona de la colonizacion de Chane-Pirai. La evaluacion de 120 casos referente a la edad al primer parto (E.P.P.), d ovinos en cruzamiento absorbente entre ovejas criollas de lana y machos de la raza Katadhin y San Javierino, registrandose un promedio general de 466 +-11.52 dias un coeficientes de variacion de 25.37 por ciento. Las ovejas criollas presentaron un promedio de 634 dias para la E.P.P. (20.8 meses), entre tanto, las ovejas puras de pelo por cruza se encontro un promedio de 429 dias (14,5 por ciento). Los analisis estadisticos, muestran una tendencia ecentuada de disminucion en la edad al primer parto de acuerdo al aumento de sangre tropical (de pelo), en los genotipos que se generaron en el programa de cruzamiento absorvente. Al mismo tiempo se analizaron 225 casos de intervalo entre partos (I.E.P.), de los genotipos de ovinos en estudios, registrandose un promedio general de 234+-4.01 dias(7.7meses), para ovejas con mas de dos partos y un coeficiente de variacion de 25,62 por ciento. La evaluaciones de los grupos raciales dentro del programa de cruzamiento absorvente verificaron que las ovejas criollas de lana presentaron el mayor I.E.P., 268 dias (8.8meses), entre tanto, las ovejas puras de pelo por cruza registraron un promedio de 229 dias (7.5meses), observaron una tendencia marcada de la disminucion de los intervalos entre partos, en la medida como aumento el porcentaje de sangre tropical en el rebaño. La estacion de parto no afecto significativamente la duracion de los intervalos, sin embrago, las ovejas paridas en la estacion de primavera (oct-nov-dic), registran los menores I.E.P. (213 dias) y la otoño (abr-may-jun), los mayores intervalos, (250 dias).