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1.
Psoriasis (Auckl) ; 12: 177-185, 2022.
Article in English | MEDLINE | ID: mdl-35791415

ABSTRACT

Purpose: Dimethyl fumarate (DMF) is an oral formulation approved for the treatment of moderate-to-severe psoriasis in adult patients requiring systemic therapy. Here, we describe our clinical experience with DMF for moderate-to-severe psoriasis in Spain. Patients and Methods: This is a retrospective study including 30 adult patients with moderate-to-severe psoriasis under treatment with DMF between September 2018 and January 2020. Patients were treated with DMF as per its Summary of Product Characteristics and the median duration of treatment was 15 weeks (4-55 weeks). Psoriasis Area and Severity Index (PASI) and body surface area (BSA) severity scales were evaluated from baseline to week 36 and adverse events (AEs) developed during treatment were described. Results: The efficacy of DMF was assessed at week 8 and at week 36 (n = 5), both PASI and BSA were 0. At week 24, median PASI showed a decrease in both the last observation carried forward (LOCF; n = 23) and the observed cases (OC) (n = 10): from 10 to 6 and from 10 to 1.5, respectively. Median BSA also showed a decrease from 19 to 10 in LOCF and from 17 to 3 in OC. The most frequent AEs were diarrhoea (40.0%), flushing (13.3%) and lymphopenia (3.3%). In 47.1% patients, AEs have been solved by adjusting the DMF dose. Treatment discontinuation rate due to AEs was 43.3%. Conclusion: Our clinical experience indicates that DMF could be an effective and safe treatment for moderate-to-severe psoriasis in adult patients.

7.
Dermatol Online J ; 26(9)2020 Sep 15.
Article in English | MEDLINE | ID: mdl-33054946

ABSTRACT

Discrete papular mucinosis is a rare variant of primary cutaneous mucinosis. Involvement of genitalia is extremely rare and can mimic molluscum contagiosum. We report the second case of a papular mucinosis with an exclusive genital involvement.


Subject(s)
Molluscum Contagiosum/diagnosis , Penile Diseases/diagnosis , Scleromyxedema/diagnosis , Adult , Diagnosis, Differential , Humans , Male , Penile Diseases/pathology , Scleromyxedema/pathology
8.
World J Pediatr ; 16(6): 629-632, 2020 12.
Article in English | MEDLINE | ID: mdl-32901377

ABSTRACT

BACKGROUND: To describe the cutaneous acral findings in a pediatric population noticed during this pandemic. METHODS: A retrospective descriptive study was performed collecting data on 36 patients under 14 years old, presenting suspicious acral skin manifestations for coronavirus disease 2019 (COVID-19). RESULTS: Patients were mostly male (63.8%). The mean age was 11.11 years. 66.67% of patients showed erythematous papules, and 44.44% purpuric macules. Feet were affected in 97.22% of patients and hands in 5.55%. Lesions were asymptomatic in 50% of patients. 30.55% of patients showed extracutaneous findings, preceding skin lesions in 12.62 days. Seven patients underwent specific severe acute coronavirus 2 (SARS-CoV-2) testing; all of these patients tested negative. CONCLUSIONS: The association between these symptoms and SARS-CoV-2 remains unclear. We recommend using these manifestations as a sign of SARS-CoV-2 infection in children. This could lead to the examination of asymptomatic and mildly symptomatic children so that contagions may be avoided.


Subject(s)
Coronavirus Infections/epidemiology , Erythema/epidemiology , Pandemics/statistics & numerical data , Pneumonia, Viral/epidemiology , Pruritus/epidemiology , Adolescent , Age Distribution , COVID-19 , Child , Child, Preschool , Cohort Studies , Comorbidity , Coronavirus Infections/diagnosis , Erythema/diagnosis , Female , Hospitals, Urban , Humans , Incidence , Male , Pneumonia, Viral/diagnosis , Prognosis , Pruritus/diagnosis , Retrospective Studies , Risk Assessment , Sex Distribution , Skin Diseases/diagnosis , Skin Diseases/epidemiology , Spain/epidemiology
12.
Diagn Microbiol Infect Dis ; 82(1): 20-5, 2015 May.
Article in English | MEDLINE | ID: mdl-25703895

ABSTRACT

Bordetella bronchiseptica is a well-known veterinary pathogen, but its implication in human disease is probably not fully recognized. The purpose of this study was to determine the clinical significance of 36 B. bronchiseptica isolates from respiratory samples of 22 patients. Therefore, we describe microbiological characteristics, including phenotypic and genotypic identification as well as antimicrobial susceptibilities of the isolates. Clonal relatedness was evaluated using pulsed-field gel electrophoresis (PFGE). Most of the patients had some underlying immunosuppressive condition. Eighteen out of 22 (82%) patients had respiratory symptoms, and the death of 2 patients was associated with respiratory infection.All strains were correctly identified at species level by the simultaneous use of phenotypic methods and were confirmed by specific amplification of the upstream region of the fla gene. Tigecycline, minocycline, doxycycline, colistin, and meropenem were the most active agents tested. PFGE analysis revealed that repeated infections involving each patient had been caused by the same strain.


Subject(s)
Bordetella Infections/diagnosis , Bordetella Infections/pathology , Bordetella bronchiseptica/isolation & purification , Respiratory Tract Infections/diagnosis , Respiratory Tract Infections/pathology , Adult , Aged , Aged, 80 and over , Anti-Bacterial Agents/pharmacology , Bacterial Typing Techniques , Bordetella Infections/microbiology , Bordetella bronchiseptica/classification , Bordetella bronchiseptica/drug effects , Bordetella bronchiseptica/genetics , Cluster Analysis , Electrophoresis, Gel, Pulsed-Field , Female , Genotype , Humans , Infant , Male , Microbial Sensitivity Tests , Middle Aged , Molecular Typing , Phenotype , Respiratory Tract Infections/microbiology , Retrospective Studies , Young Adult
13.
J Pediatr Gastroenterol Nutr ; 56(6): 657-62, 2013 Jun.
Article in English | MEDLINE | ID: mdl-23403437

ABSTRACT

OBJECTIVE: The aim of the present study was to explore the relation between lung function and serum retinol (SR) in cystic fibrosis (CF) patients. METHODS: This was a cross-sectional study conducted in a group of 98 young patients with CF (6.8-22.3 years), after the exclusion of those with pulmonary exacerbation, vitamin A deficiency, or other risks, from an initial group of 124 cases. RESULTS: Data of forced expiratory volume in 1 second (FEV1) were widely scattered (87.7% ± 16.9%). These were similar in the 78 pancreatic insufficient and 11 pancreatic sufficient patients. SR (56.6 ± 18.4 µg/dL) was >2.5th percentile of healthy people in the whole group, although 31 patients were situated above the 97.5th percentile (higher value: 110 µg/dL). The FEV1 was noticeably higher in these than in those within the normal range (93.6 ± 14.0 vs 85.0 ± 17.6 µg/dL; P < 0.05). The z score of SR correlated positively with FEV1 (r = 0.364; P = 0.000), after adjusting data for sex, age, body mass index, and pancreatic function. The odds ratio for a FEV1 >80% is 3.78 in patients with SR above the 97.5th percentile, versus only 0.26 in those within the normal range. There were no cases with retinol toxicity. CONCLUSIONS: FEV1 of young patients with CF correlates positively with SR, regardless of age, pancreatic function, or nutritional condition. Those with a moderately high retinol (up to 110 µg/dL) maintain the best respiratory function (FEV1 ≥80% in >90% of them) without any signs of toxicity.


Subject(s)
Cystic Fibrosis/blood , Cystic Fibrosis/physiopathology , Lung/physiopathology , Up-Regulation , Vitamin A/blood , Adolescent , Adult , Antioxidants/adverse effects , Antioxidants/analysis , Antioxidants/therapeutic use , Body Mass Index , Child , Cohort Studies , Cross-Sectional Studies , Cystic Fibrosis/diet therapy , Dietary Supplements/adverse effects , Exocrine Pancreatic Insufficiency/etiology , Female , Forced Expiratory Volume , Humans , Male , Odds Ratio , Oxidative Stress , Prospective Studies , Thinness/etiology , Vitamin A/adverse effects , Vitamin A/therapeutic use , Young Adult
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