ABSTRACT
WHAT IS KNOWN AND OBJECTIVE: To report five cases with a probable interaction between acenocoumarol and levofloxacin. CASE DESCRIPTION: In five patients on long-term acenocoumarol treatment who had had stable international normalized ratios for at least 6 months, sudden erratic changes in the values of these ratios were observed after 1.5-8 days of concomitant levofloxacin treatment with no other apparent cause. WHAT IS NEW AND CONCLUSIONS: Closer monitoring should be considered in patients with concomitant use of acenocoumarol and levofloxacin, especially elderly patients and those with renal dysfunction who seemed to suffer the interaction more severely.
Subject(s)
Acenocoumarol/adverse effects , Anti-Bacterial Agents/adverse effects , Anticoagulants/adverse effects , Drug Interactions/physiology , Levofloxacin/adverse effects , Acenocoumarol/therapeutic use , Aged, 80 and over , Anti-Bacterial Agents/therapeutic use , Anticoagulants/therapeutic use , Female , Humans , Levofloxacin/therapeutic use , MaleABSTRACT
No disponible
No disponible
Subject(s)
Female , Aged , Humans , Anti-Ulcer Agents/adverse effects , Nephritis, Interstitial/chemically induced , Omeprazole/adverse effects , Nephritis, Interstitial/diagnosis , Nephritis, Interstitial/therapy , Treatment OutcomeABSTRACT
The interaction between atracurium and the two calcium antagonists verapamil and diltiazem were studied in rabbits. It was observed that intravenous verapamil (0.2 mg/kg) reduced by 25% and 30% respectively, the dose of atracurium required to produce a 50% or 95% of neuromuscular blockade. In contrast, intravenous diltiazem (1 mg/kg) failed to produce significant changes.
