ABSTRACT
La demencia es reconocida como un problema de salud pública con incidencia y prevalencia elevadas, incremento en su carga de enfermedad y asociada a mortalidad. Los diferentes tratamientos no han probado tener resultados clínicos que modifiquen el curso de la enfermedad o reduzcan su impacto en términos de mortalidad o discapacidad. Esta revisión señala que es factible evitar el desarrollo de demencia a pesar de que la edad sigue siendo un importante factor de riesgo no modificable. El control de factores modificables ampliamente reconocidos y ligados etiopatogénicamente pueden disminuir el número de casos de demencia. Las intervenciones multimodales enfocadas en el control de estos factores de riesgo aún tienen resultados inconsistentes; por lo tanto, nuevos ensayos deberían ser realizados además de aplicar el enfoque de medicina de precisión clínica que permitan contar con evidencias que mejoren la toma de decisiones en salud pública para afrontar este problema
Dementia is recognised as a public health problem with high incidence and prevalence, as well as an increase in its burden of disease and associated with mortality. The different treatments have not provided clinical results that modify the course of the disease or reduce its impact in terms of mortality or disability. This review indicates that it is feasible to avoid the development of dementia despite the fact that age continues to be an important non-modifiable risk factor. The control of widely recognised modifiable and aetiopathogenically-related factors can decrease the number of cases of dementia. Multimodal interventions focused on the control of these risk factors continue to show inconsistent results; therefore, new trials should be carried out in addition to applying the clinical precision medicine approach that provides evidence to improve public health decision-making in order to address this problem
Subject(s)
Humans , Dementia/prevention & control , Precision Medicine/methods , Public Health , Age Factors , Decision Making , Dementia/epidemiology , Dementia/etiology , Prevalence , Risk FactorsABSTRACT
Dementia is recognised as a public health problem with high incidence and prevalence, as well as an increase in its burden of disease and associated with mortality. The different treatments have not provided clinical results that modify the course of the disease or reduce its impact in terms of mortality or disability. This review indicates that it is feasible to avoid the development of dementia despite the fact that age continues to be an important non-modifiable risk factor. The control of widely recognised modifiable and aetiopathogenically-related factors can decrease the number of cases of dementia. Multimodal interventions focused on the control of these risk factors continue to show inconsistent results; therefore, new trials should be carried out in addition to applying the clinical precision medicine approach that provides evidence to improve public health decision-making in order to address this problem.
