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Yakugaku Zasshi ; 127(8): 1275-9, 2007 Aug.
Article in English | MEDLINE | ID: mdl-17666881

ABSTRACT

The ethyl acetate, chloroform extracts, and the two flavonoids kaempferol 1 and kaempferol-3-O-glucoside 2 isolated from whole plants of Thesium chinense Turcz were investigated for their antiinflammatory and analgesic activities. For the antiinflammatory activity, carrageenan-induced hind paw edema and xylene-induced mouse ear edema models, and for the analgesic activity, the acetic acid-induced abdominal constriction test was used. The ethyl acetate extract and two flavonoids showed significant (p<0.05 and p<0.01) and dose-dependent antiinflammatory and analgesic activity. The chloroform extract was inactive in the assay.


Subject(s)
Edema/drug therapy , Flavonoids/therapeutic use , Pain/drug therapy , Plant Extracts/therapeutic use , Plants, Medicinal/chemistry , Santalaceae/chemistry , Animals , Carrageenan , Disease Models, Animal , Dose-Response Relationship, Drug , Edema/chemically induced , Female , Flavonoids/isolation & purification , Kaempferols/isolation & purification , Kaempferols/therapeutic use , Male , Mice , Plant Extracts/isolation & purification
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