[Results of an analysis of age and cause of death in 1,000 silicosis autopsies in the Thüringen region]. / Ergebnisse einer Analyse des Lebensalters und der Todesursachen von 1,000 obduzierten Silikosepatienten aus dem Thüringer Raum.

The authors have studied the clinical and autopsy records, including lung roentgenograms, of 1,000 silicotics deceased in the Thuringian districts of Gera, Erfurt and Suhl over the past 30 years. The main points of the analysis are clinical-pathological-anatomical comparisons in pneumoconiosis diagnoses and the identification of the cause of death. The roentgenological findings were found to be largely in correspondence with the pathological-anatomical ones. Surprisingly, the mean life span of male pneumoconiosis patients (71.3 years) is more than 2 years above the average life expectancy in the GDR, whereas the mean life span of the female patients differs little from the average GDR figure. 60.7 percent of the patients died of the sequelae of pneumoconiosis.

A mortality study of a cohort of slate quarry workers in the German Democratic Republic.

Following reports from other countries indicating an excess risk of lung cancer among silicotics, a historical cohort of workers employed for at least one year at a company in charge of slate extraction and processing during the period 1953-1985 in the German Democratic Republic has been constructed and followed up for mortality from 1970 to 1985. The results of the study show a mortality excess for infectious and respiratory diseases. The overall lung cancer mortality is not in excess but shows a tendency to increase with time since first exposure. A mortality excess from lung cancer is concentrated among workers receiving compensation for silicosis, suggesting a possible carcinogenic risk for individuals suffering from this pathological condition.

[The frequency of bronchial carcinoma in 1,000 autopsies of cases of silicosis]. / Uber die Häufigkeit des Bronchialkarzinoms unter 1,000 autoptisch untersuchten Silikosen.

In the present examination were analysed the anamneses, necropsies and x-ray photograms of 1,000 patients (743 men and 257 women), who died from silicosis in the Thuringian area. The analysis includes a period of 30 years. The material of examination comprises autopsies from 1954 to 1983. There were 45 lung cancers, found in 42 men and 3 women. A relation to smoking habit could not be examined. The lung cancer was mainly connected with a stadium of silicosis II. Only in 6 lung cancers there was a relation to the silicosis like a cicatrice cancer assumed.

[Case report of the problem of diagnosis and therapy of mediastinal tumors with anterior venous obstruction]. / Kasuistischer Beitrag zum Problem der Diagnostik und Therapie von Mediastinaltumoren mit venöser oberer Einflussstauung.

At the instance of a patient with upper venous affluence blocking due to a space occupying process in the dorsal and medial mediastinum, the problems of differential diagnostics and therapy of this disease are discussed. In spite of intensive diagnostic efforts, the final diagnosis was only obtained at autopsy. A T-lymphoblastic non-Hodgkin-lymphoma was found.

[Juvenile malignant lymphomas. 1. Hodgkin's lymphoma]. / Maligne Lymphome im Kindesalter. 1. Hodgkin-Lymphome.

From 1970 to 1978 22 children with Hodgkin's lymphomas at the age of 4-15 years were treated at the university children's hospital of Jena. There were 16 patients with the first appearance of the disease and 6 with relapses. The stage classification was carried out after the Ann-Arbor-classification. A "staging" operation with laparotomy and splenectomy was performed in 17 children. The histological material was classified after the Rye-modification of the Lukes-Butler-classification. The clinical staging showed 8 patients in stage I, 7 in stage II, 6 in stage III and one child was in stage IV. The therapy consisted of a telecobalt irradiation extended field irradiation, total nodular and local irradiation) with a focal dose of 4500 rad and a chemotherapy (6 cycles COPP). The life-table-analysis for those patients who were primarily treated in Jena showed a complete five-year-remission rate of 92 per cent. The five-year-survival-rate for all patients (with the first appearance of the disease and with relapses) amounts to 77 per cent. After splenectomy we observed two overwhelmingly progressing aetiologically not clear infections and a pneumococcal meningitis.

[Juvenile malignant lymphomas. 2 Non-Hodgkin lymphomas]. / Maligne Lymphome im Kindesalter. 2. Non-Hodkin-Lymphome.

Between 1970 and 1978 33 children with Non-Hodgkin-lymphomas at the age of 2-15 years were treated at the university children's hospital of Jena. 27 patients showed the first appearance of the disease, 6 patients had already been treated in other hospitals and were admitted with relapses. The biopsy material was classified or re-classified after the Kiel-classification. Beside the histological classification the surface markers of the malignant cells of NHL-patients were determined. 20 of 33 children were already in stage IV (Ann-Arbor-classification). Among our patients were 6 lymphoblastic NHL of Brukitt type, 10 of the convoluted cell type and 16 unclassified and one lymphoblastic lymphoma. The main localization of the NHL were mediastinum [15] and the gastrointestinal tract [10]. The therapy consisted of irradiation and chemotherapy (2 protocols) and, in case of an abdominal localization, in the attempt at a radical operation. Patients of stage I and stage II showed a complete remission rate of 50 per cent for 3 years; patients of stages III and IV of 20 per cent only. NHL of the convoluted cell type and of the Burkitt-type proved to have worse three-year-remission rates (16 per cent and 27 per cent) than unclassified lymphoblastic NHL (42 per cent).

Sisomicin: in vitro activity and pharmacokinetics.

In vitro activity of sisomicin and gentamicin was compared in serial dilution tests for 619 bacterial strains (Staphylococcus aureus, E. coli, Proteus mirabilis, Proteus vulgaris, Enterobacter, Klebsiella, Pseudomonas aeruginosa, Salmonella, Serratia marcescens). Mean MIC of sisomicin was lower by one geometrical dilution step compared with gentamicin for Pseudomonas, Proteus vulgaris, Klebsiella, and Serratia, while it was almost identical with the other species. Resistance (MIC greater than 5 microgram/ml) against sisomicin was observed in 2% of Pseudomonas strains, resistance against gentamicin in 8%. Ten healthy adult volunteers had serum peak levels (after i,m. injection of 40 mg and 80 mg sisomicin) of 2.7 and 3.2 microgram/ml. Urine recovery (in 24 hrs) was 76%. Continuous i.v. infusion of sisomicin or gentamicin (6.6 mg/hour in 7 healthy adult volunteers) yielded in serum levels of 0.64 and 1.03 microgram/ml respectively. Biological half-life (90 minutes), urine recovery (60% in the fourth hour), renal clearance and skin blister levels at the end of infusion were almost identical for both antibiotics; total clearance was somewhat higher with sisomicin than with gentamicin.

[Danger of silicosis in pottery (author's transl)]. / Silikosegefährdung in Töpfereien.

The trade of pottery was practised already in antiquity. This very old art had culmination points of its artistic performance in several epochs. The ornamentation of the body of the ware by glazing came in use in Germany (Rhine Territory) in the 12th century. The raw material applied were plastic argils baking with colour, at that time just as now. After dressing with water the plastic material was shaped to the most different objects. It was done, either off-hand or by the aid of the potter's wheel. Dust is developing when the argils are crushed representing a danger to health if technical control of the dust is not made effective. Wearing respiratory protection apparatuses is sufficient in shorttime work but must be regularly checked according to our experience. In the production of earthenware relatively high concentrations of dust occur only temporarily, but in very few cases they may cause silicosis. Among the 35 cases of silicosis in potters observed by the different special services for prophylaxis and control of dust 25 developed by exposition in plants of the GDR. 8 of the 10 diseased persons with exposition in plants outside the GDR had worked as potters in Bunzau (Silesia). The danger of silicosis is by for less than in the porcelain industry; it can be prevented by keeping clean the places of employment. This low danger is proven also by the very long exposition time of 30--40 years in average.

[Basal cell carcinoma (basalioma solidum) on a tubed pedicle flap in the oral cavity (author's transl)]. / Basalioma solidum auf einem Rundstiellappen in der Mundhöhle

A report is given on the formation of a basal cell carcinoma (Basalioma solidum) on a tubed pedicle flap of acromiopectoral transplanted into the oral cavity. This plastic successfully covered a vast perforation of the palate after a severe wounding by shell splinters 33 years ago. The histologically proofed basal cell carcinoma (Basalioma solidum) was entirely brought to disappearance by 6000 R tumor-dose telecobalt. After 1 1/2 years the patient was without any complaint and recurrence. Etiology and pathogenesis of basal cell carcinoma (Basalioma solidum) are discussed in the light of the literature.

[On radiotherapy of the cheilocarcinoma (author's transl)]. / Zur Frage der Strahlentherapie des Lippenkarzinoms

A report is given on the results of radiotherapy in 82 cases of labial carcinoma admitted to the Radiological Clinic, Jena. The absolute 5 years' healing for primary tumours is 73,25%. The absolute 5 year's healing for relapses is 68,9%. The absolute 5 years' healing for regional lymph node metastases is 21,8%.

[Chronic berylliosis of the lungs with special regard of pathomorphology (author's transl)]. / Chronische Berylliose der Lungen unter besonderer Berücksichtigung der Pathomorphologie

The course of the disease of a berylliosis of the lungs is described with a patient, who had been working with berylliumoxide in the laboratory of a porcelain factory for about 21 months between his 16th and 20th year of life. At the age of 22 berylliosis was diagnosed radiologically and recognized as a occupational disease. At 32 years of age the patient died from the sequences of berylliosis. In this case-study the particular damages due to berylliosis are discussed depending on the different beryllium compounds. The chronic berylliosis of the lungs is pointed out in a pathologically anatomical way. It is supposed that an allergic reaction of the organism is reponsible for the pathogenesis. Special demands in the field of industrial medicine are resulting from the course of the disease.

[Results of therapy of lip neoplasms from a radiotherapeutic point of view]. / Ergebnisse der Therapie von Lippenkarzinomen aus strahlentherapeutischer Sicht

The increasing use, in recent years, of surgical methods for the treatment of labial carcinomata caused us to review the results of treatment by means of irradiation. The different methods of radiotherapy are described, and a comparison is made between the results of radiotherapy and surgical treatment. Also, cases are described in which it is indicated to use either surgical treatment or radiotherapy or a combination of the two methods.