Alpha-Glutathione S-transferase and serum aminotransferases in schistosomiasis mansoni patients with or without hepatitis C virus.

The present study evaluated alpha-Glutathione-S-transferase as a biochemical marker for hepatocellular damage in schistosomiasis mansoni patients, with or without chronic hepatitis C (HCV) patients as compared to controls. Alpha GST, ALT and AST were assayed in sera of GI: 20 schistosomiasis mansoni patients with HCV, GII: 16 schistosomiasis mansoni patients without HCV, GIII: 19 pure HCV patients and GIV: 20 normal controls. The results showed that alpha-Glutathione-S-transferase was less sensitive and less specific but more accurate than ALT & AST as a liver affection marker in HCV patients.