Estimation error bound for GRAPPA diffusion-weighted MRI.

In recent years, diffusion weight magnetic resonance imaging (DW-MRI) has become one of the most important MRI imaging modalities. The importance of the DW-MRI grew thanks to the combination of parallel magnetic resonance imaging (pMRI) techniques with the echo-planar imaging (EPI), which minimize scan time and lead to reduced distortion, allowing the DW-MRI to become a routine clinical exam. Additionally, this has brought various new parameters that influence image quality and biomarkers used in DW-MRI. This work aims to investigate the effects of these parameters on the estimation quality, by using the Cramér-Rao bound tool, which gives analytical expressions of the lower limit on the estimation error variance of different DW-MRI variables when using the pMRI technique. In particular, these bounds will be used to study and optimize the impact of different factors of generalized autocalibrating partially parallel acquisition (GRAPPA) technique and system parameters on the estimation quality of the desired clinical metrics. Moreover, the obtained results of this study can be exploited and adapted in all human body DW-MRI clinical routines, further improving disease diagnosis, and tractography studies.

Analytical performance bounds for multi-tensor diffusion-MRI.

PURPOSE: To examine the effects of MR acquisition parameters on brain white matter fiber orientation estimation and parameter of clinical interest in crossing fiber areas based on the Multi-Tensor Model (MTM). MATERIAL AND METHODS: We compute the Cramér-Rao Bound (CRB) for the MTM and the parameter of clinical interest such as the Fractional Anisotropy (FA) and the dominant fiber orientations, assuming that the diffusion MRI data are recorded by a multi-coil, multi-shell acquisition system. Considering the sum-of-squares method for the reconstructed magnitude image, we introduce an approximate closed-form formula for Fisher Information Matrix that has the simplicity and easy interpretation advantages. In addition, we propose to generalize the FA and the mean diffusivity to the multi-tensor model. RESULTS: We show the application of the CRB to reduce the scan time while preserving a good estimation precision. We provide results showing how the increase of the number of acquisition coils compensates the decrease of the number of diffusion gradient directions. We analyze the impact of the b-value and the Signal-to-Noise Ratio (SNR). The analysis shows that the estimation error variance decreases with a quadratic rate with the SNR, and that the optimum b-values are not unique but depend on the target parameter, the context, and eventually the target cost function. CONCLUSION: In this study we highlight the importance of choosing the appropriate acquisition parameters especially when dealing with crossing fiber areas. We also provide a methodology for the optimal tuning of these parameters using the CRB.