ABSTRACT
Microflow technology is established as a modern and fashionable tool in synthetic organic chemistry, bringing great improvement and potential, on account of a series of advantages over flask methods. The study presented here focuses on the application of flow chemistry process in performing an efficient multiple step syntheses of (±)-fluoxetine as an alternative to conventional synthetic methods, and one of the few examples of total synthesis accomplished by flow technique.
Subject(s)
Chemistry, Organic/methods , Fluoxetine/chemical synthesis , Chemistry, Organic/instrumentation , Fluoxetine/chemistry , Halogens/chemistry , Stereoisomerism , Substrate SpecificityABSTRACT
Organic synthesis in microreactors is a novel way of performing reactions in a highly controlled way. The benefits of microreactors result from their physical properties, such as enhanced mass and heat transfer as well as regular flow profiles leading to improved yields with increased selectivities.
