Therapeutic approach to chickenpox in children and adults--our experience.

INTRODUCTION: Chickenpox is highly contagious childhood disease which occurs as a result of varicella-zoster virus primary infection. Symptomatic therapy is usually adequate for chickenpox, but in some cases it requires combinations of antiviral drugs and antibiotics. OBJECTIVES: To present our expirience with chickenpox therapy in children and adult patients. MATERIAL AND METHODS: Study included 120 randomly chosen patients, 60 adults and 60 children, with confirmed chickenpox infection, hospitalised at Clinic for infectious diseases in Sarajevo. Observed period was 1st January 2005. to 30th June 2011. We compared used therapy and outcome of disease. RESULTS: We had 333 patients with confirmed chickenpox in mentioned period. Male sex prevailed. Antiviral (acyclovir) therapy was initiated in 8(13.5%) adults and 16(27%) children. Most frequently used antibiotic was Co-Amoxiclav in a group of adults and Ceftriaxone in a group of children. DISCUSSION AND CONCLUSION: We use different terapeutical approaches to chickenpox according to the severity of the clinical picture and the existence of underlying diseases. Symptomatic treatment is indicated in all immunocompetent patients with no signs of complications. Use of corticosteroids remains open dillemma. Our therapeutical approcach followed by actual guidelines proved to be usefull. No death cases were recorded in these

Staphylococcal sepsis and frequency of metastatic foci.

INTRODUCTION: Staphylococcal sepsis is one of the most serious bacterial infections in the world, in most cases accompanied by metastatic foci in various organ systems. OBJECTIVE: analyze the metastatic foci patients suffering from staphylococcal sepsis. PATIENTS AND METHODS: we analyzed the patients treated for staphylococcal sepsis during the ten year period. RESULTS: 67 patients were included, of which 45 (67,2%) with the outpatient acquired infection and 22 (32.8%) hospital acquired. Male was present in higher percentage 58.2% and the average age of patients was 39 years. Meticillin-sensitive strains are present in 73.1% and resistant isolates in 26.9%. Chi square test of independence showed a dependence isolated pathogens in relation to the place of infection p = 0,003. From the total number of metastatic foci, 39 was in the lung, 32 in the skin and subcutaneous tissue, 24 in the abdomen, 15 in the bones and joints, 11 heart and brain 2. CONCLUSION: The greatest number of metastases was in the lung. Significantly large number of patients had outpatient infection with predominance of meticillin sensitive strains while in hospital infections in a greater percentage were meticillin rezistent strains. Proven dependence of isolated pathogens in relation to the place of infection (outpatient/hospital).

Complicated Varicella Infection at 8-year-old Boy with Pulmonary Agenesis.

CONFLICT OF INTEREST: none declared. INTRODUCTION: Varicella or chickenpox is highly contagious, childhood infectious disease caused by primary infection with varicella - zoster virus from the herpes family of viruses. Usually it has a mild clinical course, rarely with described complication, mostly affecting respiratory tract and rarely the central nervous system. CASE REPORT: The case present 8 year old boy hospitalized eighth day of disease with clinical pictures of varicella complication. Upon receipt tachydyspnea, high fever, tachycardia, hypotensive with positive findings on lung auscultation in the sense of pneumonia. Extremely high values of non-specific inflammatory parameters are implied on bacterial infection which is treated using triple antimicrobial therapy and antiviral. A detailed clinical, laboratory and radiological evaluation is determined of clinical disease complication under a picture of MODS that required prolonged multidisciplinary treatment in ICU. CONCLUSION: The disease had a favorable clinical outcome in terms of training completely without consequences but, with the detected congenital absence lower lobe of right lung and transposition of the brachiocephalic trunk.