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1.
PLoS One ; 16(3): e0247947, 2021.
Article in English | MEDLINE | ID: mdl-33661974

ABSTRACT

This study aimed to evaluate the association of periodontitis with the organoleptic score (OLS)-defined oral malodor after validating OLS with odoriferous sulfur compounds in mouth air among Korean adults. A total of 330 adults aged 47-86 years were recruited from the Yangpyeong health cohort, South Korea, in 2015. Oral malodor was assessed using a 6-point OLS by a trained dentist and validated with the concentrations of hydrogen sulfide (HS) and methyl mercaptan (MM) using a gas chromatographer. Periodontitis was measured by assessing the radiographic alveolar bone loss on digital orthopantomography. Statistical analyses including descriptive statistics, partial correlation, ANOVA, and multivariable logistic regression with putative confounders were applied. OLS was significantly correlated with the concentrations of HS and MM (partial r = 0.401 and 0.392, respectively; both p<0.001) after controlling for confounders. Individuals with periodontitis had 1.8 times the risk of OLS-defined oral malodor in multivariable models (adjusted odds ratio = 1.77 in the model with the number of teeth and 1.82 in the model with denture wearing; p = 0.047 and 0.035, respectively). Periodontitis was associated with OLS-defined oral malodor among Korean adults independent of known confounders. Periodontal conditions should be considered for clinical practice and research of oral malodor.


Subject(s)
Halitosis/etiology , Periodontitis/complications , Aged , Aged, 80 and over , Cross-Sectional Studies , Female , Halitosis/diagnosis , Humans , Male , Middle Aged , Periodontitis/diagnosis , Republic of Korea/epidemiology , Sensation , Sulfur Compounds/analysis
2.
PLoS One ; 12(5): e0177074, 2017.
Article in English | MEDLINE | ID: mdl-28489936

ABSTRACT

BACKGROUNDS: The association of dietary vitamin C (vit C) on periodontitis requires more valid evidence from large representative samples to enable sufficient adjustments. This study aimed to evaluate the association between dietary vit C intake and periodontitis after controlling for various confounders in the representative Korean adult population. METHOD: A total of 10,930 Korean adults (≥19 years) from the fourth Korean National Health and Nutrition Examination Survey data set were included in this cross-sectional study. Periodontitis was defined as community periodontal index score of 3 or 4. Dietary vit C intake was estimated from a 24-hour dietary record, and categorized into adequate and inadequate according to the Korean Estimated Average Requirement value. Potential confounders included age, sex, income, frequency of tooth brushing, use of floss, dental visit, drinking, smoking, diabetes, hypercholesterolemia, hypertension, and obesity. A multivariable logistic regression analysis and stratified analysis were applied. RESULTS: Those with inadequate dietary vit C intake were more likely by 1.16 times to have periodontitis than those with adequate dietary vit C intake (adjusted odds ratio [aOR] = 1.16, 95% confidence interval = 1.04-1.29). Lowest and middle-low quartile of dietary vit C intake, compared to highest quartile of dietary vit C intake, showed significant association (aOR = 1.28 and 1.22 respectively), which was in a biological-gradient relationship (trend-p <0.05). CONCLUSIONS: Our data showed that inadequate dietary vit C intake was independently associated with periodontitis among Korean adults. Hence, adequate intake of dietary vitamin C could be substantially important on the promotion of periodontal health among Korean adults.


Subject(s)
Ascorbic Acid/therapeutic use , Periodontitis/epidemiology , Periodontitis/prevention & control , Vitamins/therapeutic use , Adult , Aged , Alcohol Drinking/epidemiology , Cross-Sectional Studies , Diabetes Mellitus/epidemiology , Female , Humans , Income , Male , Middle Aged , Nutrition Surveys , Obesity/epidemiology , Odds Ratio , Periodontal Index , Republic of Korea/epidemiology , Smoking/epidemiology , Toothbrushing , Young Adult
3.
J Clin Periodontol ; 43(12): 1032-1040, 2016 12.
Article in English | MEDLINE | ID: mdl-27487155

ABSTRACT

AIM: This study aims to evaluate the association of salivary matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8) with periodontitis and its screening ability on periodontitis. MATERIAL AND METHODS: We selected 693 participants from the Yanypyeong Cohort: 577 participants with periodontitis and 116 participants without periodontitis. Periodontitis was assessed by dentists using a panoramic radiograph. Salivary MMP-9 and IL-8 were assayed using multiplexed bead immunoassay (Luminex). MMP-9 and IL-8 were categorized into low, medium and high. Age, sex, income, smoking, drinking, exercise, obesity and metabolic syndrome were confounders. Logistic regression analysis was applied to evaluate the association between MMP-9, IL-8 and periodontitis. Receiver operating characteristic curve was applied for sensitivity, specificity and c-statistics. RESULTS: High MMP-9 and medium IL-8 were associated with periodontitis: adjusted odds ratio were 2.2 [95% confidence interval (CI): 1.3-3.7] for MMP-9 and 1.9 (95% CI: 1.1-3.4) for IL-8. The final screening model using salivary MMP-9 for periodontitis had a sensitivity of 0.46, specificity of 0.77 and c-statistic of 0.63 (p < 0.001). CONCLUSIONS: Our data show that salivary MMP-9 and IL-8 could be potential markers for periodontitis. The screening model for periodontitis could be useful in clinics and home. A future prospective study is indicated for predicting the occurrence of periodontitis.


Subject(s)
Periodontitis , Adult , Asian People , Humans , Interleukin-8 , Matrix Metalloproteinase 8 , Matrix Metalloproteinase 9 , Prospective Studies
4.
Atherosclerosis ; 251: 311-318, 2016 08.
Article in English | MEDLINE | ID: mdl-27450785

ABSTRACT

BACKGROUND AND AIMS: We aimed to evaluate the association of periodontitis with the development of early atherosclerotic vascular disease in Korean adults. METHODS: In this cross-sectional study, a total of 1343 adults aged over 40 years were recruited from a community-based cohort of Yangpyeong county, Korea, during the period 2010-2014. Only dentate individuals were included in the study. Subclinical atherosclerosis (SA) was defined as carotid intima-media thickness (cIMT)≥0.754 mm, as assessed bilaterally by B-mode ultrasound. Peripheral arterial disease (PAD) was defined as ankle-brachial index (ABI)≤1.0, as measured by Doppler. History of periodontitis was assessed by measuring the radiographic alveolar bone loss (RABL) on a digital dental panorama and was classified into three groups: normal, moderate and severe periodontitis (≥2 non-adjacent interproximal sites with RABL≥4 mm and 6 mm, respectively). The associations of periodontitis with SA and PAD were evaluated by multivariable logistic regression analysis and analysis of covariance, adjusted for age, sex, education level, tooth loss, smoking, drinking, exercise, obesity, triglycerides, HDL, LDL, hs-CRP, diabetes and hypertension. Stratified analyses were performed to identify specific risk groups. RESULTS: After controlling for confounders, severe periodontitis was associated with SA [adjusted odds ratio (aOR) = 1.55; 95% confidence interval (CI): 1.07-2.24] and PAD (aOR = 2.03; 95% CI: 1.05-3.93). These associations were highlighted in never-smokers. For increasing severity of periodontitis, the adjusted mean cIMT increased (p = 0.011) while that of ABI decreased (p = 0.033). CONCLUSIONS: Our data showed that periodontitis is a substantially important risk factor for atherosclerotic vascular disease among Korean adults.


Subject(s)
Atherosclerosis/complications , Atherosclerosis/ethnology , Periodontitis/complications , Periodontitis/ethnology , Peripheral Arterial Disease/complications , Peripheral Arterial Disease/ethnology , Adult , Aged , Carotid Intima-Media Thickness , Cohort Studies , Cross-Sectional Studies , Female , Genetic Association Studies , Genetic Predisposition to Disease , Humans , Inflammation , Male , Middle Aged , Multivariate Analysis , Odds Ratio , Regression Analysis , Republic of Korea/epidemiology , Risk Factors
5.
Community Dent Oral Epidemiol ; 44(4): 381-9, 2016 08.
Article in English | MEDLINE | ID: mdl-26919660

ABSTRACT

OBJECTIVES: This study aimed to evaluate the association between salivary 8-hydroxydeoxyguanosine (8-OHdG) and periodontitis among community-dwelling Korean adults. METHODS: A total of 211 adults (80 men and 131 women) were cross-sectionally surveyed from the Sunchang Longevity Cohort. Periodontitis was defined as having at least 30% of teeth with proximal attachment loss ≥5 mm. The salivary 8-OHdG level was categorized into tertiles: low (<0.916 ng/ml), medium (0.916 to <2.675 ng/ml) and high (≥2.675 ng/ml). Sociodemographic, habitual and systemic health-related factors were controlled for. Logistic regression analysis was performed for the outcome of severe periodontitis. Analysis of covariance in general linear model was performed for the outcome of 8-OHdG. RESULTS: The high 8-OHdG level showed a significant association with periodontitis. The odds ratio (95% confidence interval) was 2.40 (1.05-5.51), and it was highlighted by adding the interaction term with drinking and smoking. The adjusted mean log-transformed value of 8-OHdG was significantly higher in the severe periodontitis group (1.40 ng/ml) than in the control group (1.02 ng/ml) (ancova, P = 0.028). CONCLUSIONS: 8-OHdG was associated with periodontitis. Thus, salivary 8-OHdG could be a useful marker for periodontitis.


Subject(s)
Deoxyguanosine/analogs & derivatives , Periodontitis/metabolism , Salvia/chemistry , 8-Hydroxy-2'-Deoxyguanosine , Aged , Aged, 80 and over , Cross-Sectional Studies , Deoxyguanosine/analysis , Female , Humans , Logistic Models , Male , Middle Aged , Periodontitis/diagnosis , Republic of Korea/epidemiology , Rural Population/statistics & numerical data
6.
J Am Geriatr Soc ; 64(1): 162-7, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26782867

ABSTRACT

OBJECTIVES: To investigate the association between periodontitis and cognitive impairment in elderly Koreans. DESIGN: Cross-sectional study with age- and sex-matched case-control selection. SETTING: The Yangpyeong cardiovascular cohort (YCC), a part of the Korean Genome Epidemiologic Study (KoGES), Yangpyeong, South Korea. PARTICIPANTS: Individuals with cognitive impairment (n=65) and cognitively normal controls (n=124) aged 60 and older from the YCC. MEASUREMENTS: Alveolar bone loss was assessed on dental panoramic radiographs to categorize the cumulative history of periodontitis (HOP) into three groups: normal, moderate periodontitis, severe periodontitis. The Mini-Mental State Examination (MMSE) was used to categorize participants as cognitively normal or cognitively impaired. Age- and sex-matched conditional logistic regression models were used for analysis. Confounders considered in the analysis were age, sex, drinking, smoking, exercise, total cholesterol, total protein, body mass index, fasting plasma glucose, intima-media thickness, hypertension medication, and depression. RESULTS: Participants with HOP were more likely to have cognitive impairment than those without (odds ratio=2.14, 95% confidence interval=1.04-4.41). The interaction effect of smoking and exercise on periodontitis highlighted the link. CONCLUSION: Periodontitis was independently associated with cognitive impairment after controlling for various confounders. Further longitudinal research is needed to determine whether periodontitis plays a role in cognitive decline in older adults.


Subject(s)
Cognition Disorders , Periodontitis , Age Factors , Aged , Body Mass Index , Cognition Disorders/diagnosis , Cognition Disorders/epidemiology , Cohort Studies , Comorbidity , Cross-Sectional Studies , Female , Humans , Hypertension/epidemiology , Intelligence Tests , Male , Middle Aged , Periodontitis/diagnosis , Periodontitis/epidemiology , Radiography, Panoramic/methods , Republic of Korea/epidemiology , Risk Factors , Sex Factors , Smoking/epidemiology , Statistics as Topic
7.
J Clin Periodontol ; 42(11): 998-1005, 2015 Nov.
Article in English | MEDLINE | ID: mdl-26461204

ABSTRACT

AIM: To evaluate the association of hypertension and high systolic and diastolic blood pressure (SBP and DBP) with periodontitis in a nationally representative Korean adult population. MATERIALS AND METHODS: Total of 14,625 participants of Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV) aged over 19 years were cross-sectionally surveyed. Periodontitis was defined as CPI score of 3 or 4. Hypertension was categorized as: normotensive (SBP < 120 mmHg and DBP < 80 mmHg), pre-hypertensive (120 < SBP < 140 mmHg or 80 < DBP < 90 mmHg) and hypertensive (SBP ≥ 140 mmHg or DBP ≥ 90 mmHg or taking antihypertensive medication). Multivariate Poisson regression analyses were performed controlling for age, sex, household income, drinking, smoking, physical activity, obesity, hypercholesterolaemia and diabetes mellitus. Stratified analyses were performed to identify specific risk groups. RESULTS: Hypertension showed a significant positive association with periodontitis in the fully adjusted model in female adults with a dose-response relationship. This association was highlighted in females aged 30-59 years (prevalence ratio = 1.25; 95% confidence interval: 1.11-1.40). The strength of the association was highest in females aged 30-39 years and decreased with increasing age. Among females aged 30-59 years, high-risk groups of this link were lower middle income quartile, never drinker and non-diabetes groups for both pre-hypertension and hypertension. CONCLUSION: Our data showed that hypertension was associated with periodontitis in Korean female adults independent of known confounders.


Subject(s)
Hypertension , Periodontitis , Adult , Blood Pressure , Female , Humans , Hypertension/drug therapy , Middle Aged , Nutrition Surveys , Periodontitis/epidemiology , Republic of Korea/epidemiology , Young Adult
8.
J Clin Periodontol ; 42(8): 703-710, 2015 Aug.
Article in English | MEDLINE | ID: mdl-26212799

ABSTRACT

AIM: This study aims to locate the genes related to periodontitis through genome-wide association study (GWAS) in Korean population. METHODS: Total of 677 adults aged 44-88 years were recruited from the Yangpyeong cohort in Korea. The participants did not have self-reported metabolic diseases, cardiovascular diseases or cancer. Periodontitis was assessed using alveolar bone loss from a digital panoramic radiograph and classified into three groups: normal to mild, moderate and severe periodontitis. DNA from blood samples were genotyped using the Illumina Human 1M-duo Beadchip. Multivariable logistic regression analysis in PLINK was applied to examine the single-nucleotide polymorphisms (SNPs) related to periodontitis after controlling for various confounders. RESULTS: Associations of three SNPs suggested TENM2 (rs4242220) and LDLRAD4 (rs12969041, rs2027756) as putative risk genes of chronic periodontitis (p-values <1 × 10-5 ). The odds ratio [95% confidence interval (CI)] of TENM2 was 0.53 (0.40-0.70) for moderate periodontitis and that of LDLRAD4 was 2.86 (1.92-4.27) for severe periodontitis. Two nonsynonymous SNPs of protein coding region and seven SNPs selected from previous reports showed nominal association. CONCLUSION: Our GWAS supports a previously reported gene of TENM2 and newly suggests LDLRAD4. These two genes' role on lipid metabolism may play a part in the molecular aetiology of periodontitis.

9.
J Periodontol ; 85(12): 1676-83, 2014 Dec.
Article in English | MEDLINE | ID: mdl-24965062

ABSTRACT

BACKGROUND: This study aims to evaluate and validate a periodontitis screening model that includes sociodemographic, metabolic syndrome (MetS), and molecular information, including gingival crevicular fluid (GCF), matrix metalloproteinase (MMP), and blood cytokines. METHODS: The authors selected 506 participants from the Shiwha-Banwol cohort: 322 participants from the 2005 cohort for deriving the screening model and 184 participants from the 2007 cohort for its validation. Periodontitis was assessed by dentists using the community periodontal index. Interleukin (IL)-6, IL-8, and tumor necrosis factor-α in blood and MMP-8, -9, and -13 in GCF were assayed using enzyme-linked immunosorbent assay. MetS was assessed by physicians using physical examination and blood laboratory data. Information about age, sex, income, smoking, and drinking was obtained by interview. Logistic regression analysis was applied to finalize the best-fitting model and validate the model using sensitivity, specificity, and c-statistics. RESULTS: The derived model for periodontitis screening had a sensitivity of 0.73, specificity of 0.85, and c-statistic of 0.86 (P <0.001); those of the validated model were 0.64, 0.91, and 0.83 (P <0.001), respectively. CONCLUSIONS: The model that included age, sex, income, smoking, drinking, and blood and GCF biomarkers could be useful in screening for periodontitis. A future prospective study is indicated for evaluating this model's ability to predict the occurrence of periodontitis.


Subject(s)
Mass Screening/statistics & numerical data , Periodontitis/diagnosis , Adolescent , Adult , Aged , Alcohol Drinking , Biomarkers/analysis , Biomarkers/blood , Cohort Studies , Early Diagnosis , Female , Gingival Crevicular Fluid/chemistry , Gingival Crevicular Fluid/enzymology , Humans , Income , Interleukin-6/blood , Interleukin-8/blood , Male , Matrix Metalloproteinase 13/analysis , Matrix Metalloproteinase 8/analysis , Matrix Metalloproteinase 9/analysis , Metabolic Syndrome/diagnosis , Middle Aged , Periodontal Index , Republic of Korea , Sensitivity and Specificity , Smoking , Tumor Necrosis Factor-alpha/blood , Young Adult
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