1.
China Journal of Chinese Materia Medica
; (24): 2725-2729, 2017.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-256043
ABSTRACT
In physiological condition, the interaction of acteoside and forsythoside B with calf thymus DNA using neutral red (NR) as a fluorescence probe were investigated by fluorescence, UV-visible spectrophotometry, viscosity, DNA melting techniques, and molecular docking. It is observed that acteoside and forsythoside B can react with DNA. The major mode of recognition between drug and DNA is groove binding by hydrogen bonds, and the interaction of acteoside with DNA is stronger than that of forsythoside B.