ABSTRACT
The study revealed positive correlation between bleeding on probing and teeth loss risk with periodontal hypercolonization by Porphyromonas gingivalis, Prevotella intermedia and Treponema denticola. Pathological tooth mobility was associated with hypercolonization by P. intermedia and Tannerella forsythensis. Expression of IL8, TNF-α, MMP8 and MMP9 genes was also assessed in patient groups divided according to the depth of periodontal pockets and-the severity of chronic periodontitis revealing IL8 as positive diagnostic marker.
Subject(s)
Periodontitis/diagnosis , Periodontitis/genetics , Transcriptome , Adult , Chronic Disease , Female , Genetic Markers , Hemorrhage/etiology , Hemorrhage/genetics , Humans , Interleukin-8/genetics , Male , Matrix Metalloproteinase 8/genetics , Matrix Metalloproteinase 9/genetics , Middle Aged , Periodontal Pocket/etiology , Periodontal Pocket/genetics , Periodontitis/complications , Periodontitis/microbiology , Porphyromonas gingivalis/isolation & purification , Prevotella intermedia/isolation & purification , Risk Factors , Tooth Loss/etiology , Tooth Loss/genetics , Tooth Mobility/etiology , Tooth Mobility/genetics , Treponema denticola/isolation & purification , Tumor Necrosis Factor-alpha/genetics , Young AdultABSTRACT
The aim of the study was to evaluate the content of phosphoinositides (PI) and their metabolites in blood components to reveal the diagnostic value of these in patients with chronic generalized periodontitis. Forty-five patients (30 female and 15 male aged 21-55) with chronic generalized periodontitis, as well as 30 patients with no signs of periodontal disease were included in the study. The PI content differ significantly between the groups thus making it possible using them as diagnostic and follow-up markers.