ABSTRACT
In a recently started clinical trial, the short-term effects of radiotherapy of cervix cancer Stage IIb and III in combination with topical infusion of metronidazole solution were evaluated by determining the local clearance rate and cytologic damage in randomized and non-randomized cases. In regard to the short term effects the combined treatment was found to be superior to treatment without metronidazole.
Subject(s)
Metronidazole/therapeutic use , Uterine Cervical Neoplasms/radiotherapy , Clinical Trials as Topic , Combined Modality Therapy , Female , Humans , Metronidazole/administration & dosage , Random AllocationABSTRACT
The report deals with a comparison of the results of cytologic and clinical evaluation of the effectiveness of different methods of radiotherapy in 93 cases of cervical carcinoma. A correlation established between cytologic data and clinical manifestations suggested that cytologic procedures be used as a criterion for ascertaining tumor radiosensitivity. The advantages offered by application of modifiers of tumor radiosensitivity are discussed.
Subject(s)
Uterine Cervical Neoplasms/pathology , Adenocarcinoma/pathology , Adenocarcinoma/radiotherapy , Brachytherapy , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/radiotherapy , Combined Modality Therapy , Evaluation Studies as Topic , Female , Gamma Rays/therapeutic use , Humans , Metronidazole/therapeutic use , Oxygen Inhalation Therapy , Radiotherapy Dosage , Uterine Cervical Neoplasms/radiotherapy , Vaginal SmearsABSTRACT
A gastroscopic examination of 58 patients with atrophic gastritis established focal hyperplasia in 3.5% of cases. Endoscopically, focal hyperplasia appeared as flat plaques, tuberosity and short folds. Early plaque-shaped cancer of the stomach was suspected in 13 cases which was histologically confirmed in I case. Different forms of atrophic gastritis were detected in 56.9% of cases of focal hyperplasia by histological examination of the material obtained by aiming gastrobiopsy. It is suggested that focal hyperplasia is an endoscopic manifestation of dysregeneratory process occurring in gastric mucosa.
Subject(s)
Gastric Mucosa/pathology , Adult , Aged , Biopsy , Diagnosis, Differential , Female , Gastritis/pathology , Gastroscopy , Humans , Hyperplasia , Male , Middle Aged , Precancerous Conditions/pathologySubject(s)
Gastritis, Atrophic/diagnosis , Gastritis/diagnosis , Precancerous Conditions/diagnosis , Stomach Neoplasms/diagnosis , Adult , Biopsy , Cytodiagnosis , Female , Gastric Mucosa/pathology , Gastritis, Atrophic/pathology , Gastroscopy , Humans , Kazakhstan , Male , Middle Aged , Polyps/diagnosis , Polyps/pathology , Precancerous Conditions/pathology , Stomach Neoplasms/pathologySubject(s)
Carcinoma, Squamous Cell/pathology , Esophageal Neoplasms/pathology , Adult , Aged , Carcinoma, Squamous Cell/therapy , Esophageal Neoplasms/therapy , Female , Follow-Up Studies , Humans , Male , Methotrexate/administration & dosage , Middle Aged , Particle Accelerators , Radiotherapy DosageABSTRACT
814 patients with various pathological changes in the uterine neck were subjected to the complex investigation, taking into consideration the fact that all specialists should be equally competent in their fields. Diagnostic errors were analysed in each method of investigation in relation to a histological conclusion in every series of patients. The diagnosis of preinvasive cancer proved to be most difficult. The number of errors was less in microcarcinoma. The organization of large colpocytological centres in big cities is advocated.
