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Diabetes Metab ; 43(1): 79-82, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27262367

ABSTRACT

BACKGROUND AND OBJECTIVES: Peripheral tissue resistance to insulin action is a characteristic of type 2 diabetes mellitus (T2DM). It has also been reported that some chronic viral infections can contribute to insulin resistance. Human herpesvirus (HHV)-8 infection has been detected in T2DM patients in previous studies. Our study investigated whether the presence of the virus is associated with insulin resistance in patients with ketosis-prone type 2 diabetes (KPD), as reported with other viruses. RESEARCH DESIGN AND METHODS: A total of 11 insulin-free KPD patients positive (+) and seven patients who were negative (-) for HHV-8 infection were recruited; the latter had KPD that was well controlled (HbA1c=6.2±0.7%). A two-step euglycaemic-hyperinsulinaemic clamp test coupled with deuterated [6,6-2H2]glucose was used to assess insulin sensitivity, non-esterified fatty acid (NEFA) suppression and endogenous glucose production. RESULTS: In KPD patients, whether HHV-8+ or HHV-8-, there were no differences in NEFA release, endogenous glucose production or insulin sensitivity (M value). CONCLUSION: Asymptomatic HHV-8 infection does not appear to be associated with decreased insulin sensitivity in diabetic patients. These results should now be confirmed in a larger sample population.


Subject(s)
Diabetes Mellitus, Type 2 , Diabetic Ketoacidosis , Herpesviridae Infections , Herpesvirus 8, Human , Insulin Resistance , Adult , Diabetes Mellitus, Type 2/epidemiology , Diabetes Mellitus, Type 2/virology , Diabetic Ketoacidosis/epidemiology , Diabetic Ketoacidosis/virology , Female , Glucose Clamp Technique , Herpesviridae Infections/complications , Herpesviridae Infections/epidemiology , Humans , Male , Middle Aged
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