[Lipid peroxidation and antioxidant defense in renal affections of exotoxic etiology]. / Pereokisnoe okislenie lipidov i sistema antioksidatnoi zashchity pri porazheniiakh pochek ekzotoksicheskoi etiologii.

Exogenic poisoning is often complicated by toxic nephropathy pathogenesis of which remains obscure. In view of this, the authors have performed a clinical study of lipid peroxidation (LPO) and antioxidant defense (AOD) in acute exogenic poisoning with renal lesion. Acute poisoning results in LPO activation and inhibition of AOD enzymes activity. Emerging toxic nephropathy aggravates disorders in the system LPO-AOD actively participating in pathogenesis of this complication.

[The state of cellular and humoral factors of nonspecific resistance and immunologic reactivity in chronic pyelonephritis]. / Sostoianie kletochnykh i gumoral'nykh faktorov nespetsificheskoi rezistentnosti i immunologicheskoi reaktivnosti pri khronicheskom pielonefrite.

Chronic pyelonephritis at the stage of exacerbation is accompanied by the development of combined immunodeficiency characterized by the inhibition of some humoral factors of nonspecific resistance, a decrease in the functional potential of the system of neutrophilic phagocytosis, quantitative deficiency of the circulating pool of thymus-dependent lymphocytes and a decrease in their functional activity combined with disturbance of antibody genesis. Immunomodulating therapy against a background of multiple modality therapy of disease was proposed.