[Enteric microbiocenotic modifiers and ways of enhancing their efficacy].

Efficient recovery of enteric microbiocenosis is one of the central problems not only in gastroenterology, but also in a number of related areas. This problem becomes particularly pressing after antibiotic treatment. The combined modifiers of enteric microbiocenosis are most effective among other symbiotic drugs. Bion-3 apart from symbionts contains a vitamin/mineral complex and acts as an adaptogen.

[Hereditary pemphigus: the problems of classification, diagnosis and prevention]. / Nasledstvennaia puzyrchatka: voprosy klassifikatsii, diagnostiki i profilaktiki.

Basic principles of present-day classification of hereditary epidermolysis bullosa are outlined, and morphologic grounds for distinguishing common, borderline, and dystrophic e. bullosa are validated. Potentialities of prenatal diagnosis of grave forms of e. bullosa as one of the major means of prevention are discussed. Data of clinical follow-up of 25 patients with common, 5 with borderline, and 29 ones with dystrophic e. bullosa are presented, as are results of 8 cases of prenatal diagnosis. The authors emphasize the necessity of electron microscopic examination of the skin in every case.

[Hallopeau-Siemens' congenital epidermolysis bullosa dystrophica]. / Vrozhdennyi distroficheskii bulleznyi épidermoliz Allopo--Simensa.

Examination of apparently intact skin of patients with generalized Hallopeau-Siemens' dystrophic epidermolysis bullosa has shown that this condition may be diagnosed histologically only in case of manifest changes. If there are no apparent changes, examination of ultrathin sections of the skin should be used. Further studies are necessary to define the diagnostic and prognostic values of the detected changes for prenatal diagnosis.

[Acicular ichthyosis (the Curth-Macklin type)]. / Iglistyi ikhtioz (tip Kurta--Maklina).

It is suggested that the double-nucleus phenomenon in the epidermis in type Curth-Macklin [correction of Kurt-McLean] acicular ichthyosis is due to cytokinesis-controlling gene mutation. Other hereditary dermatoses associated with needle-like hyperkeratosis appear to be a heterogenic group not necessarily involving the formation of double-nuclear cells. The essence of double-nucleus phenomenon and morphogenesis of acicular ichthyosis are disputable at present.

[The prenatal diagnosis of Herlitz's borderline epidermolysis bullosa letalis]. / Prenatal'naia diagnostika letal'nogo pogranichnogo bulleznogo épidermoliza Gerlittsa.

Methods of morphologic prenatal diagnosis permit optimizing the medicogenetic prognosis thus preventing the birth of patients with severe incurable forms of congenital bullous epidermolysis and preserve normal pregnancy in risk-group females. Studies on the estimation of the prognostic and prophylactic value of methods for the prenatal diagnosis of congenital dermatoses are necessary.

[Prenatal diagnosis of several hereditary skin diseases]. / Prenatal'naia diagnostika nekotorykh nasledstvennykh zabolevanii kozhi.

Twenty-two control women and 5 women at risk for delivering a baby with Brocq's ichthyosiform erythroderma or fatal epidermolysis bullosa were investigated in order to make prenatal diagnosis of inherited fetal skin diseases. Fetal skin abnormalities were detected in 3 of the 5 high-risk patients, and their pregnancies were terminated. There was a spontaneous abortion with a normal fetus in 1 case. In one woman, pregnancy progressed to term delivery of a normal girl. Methodologic aspects of obtaining fetal skin samples and the results of their morphologic studies are discussed.

[The toxicologic characteristics of a new SAKAP-based benzyl benzoate ointment]. / Toksikologicheskaia kharakteristika novoi mazi benzilbenzoata na osnove SAKAP.

The formula of a new stable 20% benzylbenzoate emulsion is presented, so are the results of studies on its toxicity, local irritating and sensitizing effects in guinea pigs. For comparison, the same characteristics of currently used 20% water-soap benzylbenzoate emulsion and of the new ointment base, SAKAP (acryl copolymer), have been examined. Both the ointment and its base have proved to be safe.

[Ultrastructural changes in the skin of patients with Fabry's angiokeratoma]. / Ul'trastrukturnye izmeneniia kozhi u bol'nykh s angiokeratomoi Fabri.

The skin of a patient with Fabry's diffuse angiokeratoma accompanied by a severe decrease of leucocyte alpha-galactosidase (0,7-1,2 nmol/mg protein/h) was studied by a method of semithin and ultrathin sections. Cytoplasmic inclusions having lamellar structure in the form of alternating electron-dense and light strips with a period about 6 nm were found in the endotheliocytes of dilated vessels, lymphoid cells, neutrophil leucocytes, axons and leucocytes of nerve trunks. The presence of these specific inclusions together with the decrease of leucocytic alpha-galactosidase allows the differential diagnosis with other types of angiokeratomas and some skin angiomas.