Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add more filters










Database
Language
Publication year range
1.
PLoS Negl Trop Dis ; 16(7): e0010570, 2022 07.
Article in English | MEDLINE | ID: mdl-35895705

ABSTRACT

BACKGROUND: Knowing the prevalence of schistosomiasis is key to informing programmes to control and eliminate the disease as a public health problem. It is also important to understand the impact of infection on child growth and development in order to allocate appropriate resources and effort to the control of the disease. METHODS: We conducted a survey to estimate the prevalence of schistosomiasis among school aged children in villages along the Albert-Nile shore line in the district of Pakwach, North Western Uganda. A total of 914 children aged between 10-15 years were screened for Schistosoma mansoni using the POC-CCA and Kato Katz (KK) techniques. The infection intensities were assessed by POC-CCA and KK as well as CAA tests. The KK intensities were also correlated with POC-CCA and with CAA intensity. Anthropometric measurements were also taken and multivariate analysis was carried out to investigate their association with infection status. RESULTS: The prevalence of schistosomiasis using the POC-CCA diagnostic test was estimated at 85% (95% CI: 83-87), being highest amongst children living closer to the Albert-Nile shoreline. Visual scoring of the POC-CCA results was more sensitive than the Kato Katz test and was positively correlated with the quantified infection intensities by the CAA test. The majority of the children were underweight (BMI<18.5), and most notably, boys had significantly lower height for age (stunting) than girls in the same age range (p < 0.0001), but this was not directly associated with S. mansoni infection. CONCLUSION: High prevalence of S. mansoni infection in the region calls for more frequent mass drug administration with praziquantel. We observed high levels of stunting which was not associated with schistosomiasis. There is a need for improved nutrition among the children in the area.


Subject(s)
Schistosomiasis mansoni , Adolescent , Animals , Antigens, Helminth/analysis , Child , Cross-Sectional Studies , Feces/chemistry , Female , Growth Disorders/epidemiology , Humans , Male , Prevalence , Schistosoma mansoni , Schistosomiasis mansoni/diagnosis , Schistosomiasis mansoni/epidemiology , Sensitivity and Specificity , Uganda/epidemiology
2.
Afr Health Sci ; 17(2): 301-307, 2017 Jun.
Article in English | MEDLINE | ID: mdl-29062323

ABSTRACT

INTRODUCTION: Both Human Immunodeficiency Virus (HIV) and S.mansoni infections are common in Uganda and can cause liver disease. No study has determined co-infection significance in Uganda. We carried out a study on the burden, pattern and factors that contribute to peri-portal fibrosis (PPF) in HIV infected patients attending a Primary healthcare setting at Pakwach. METHODOLOGY: We conducted a cross-sectional study in the HIV clinic at Pakwach health centre IV. Data on demographics, contact with the Nile, CD4+ cell count, ART and alcohol use were collected. Urinary Circulating Cathodic Antigen (CCA), was done for S. Mansoni detection. Liver scan was done for presence and pattern of PPF. HBsAg testing was performed on all participants. Data was analyzed using Stata Version 10. RESULTS: We enrolled 299 patients, median age 39 years (IQR 16), most were female, 210 (73%). Overall, 206 (68.9%) had PPF, majority 191 (92.7%) had pattern c, either alone (63 participants) or in combination with pattern d (128 participants). Age of 30-50 years was significantly associated with PPF (OR 2.28 p-value-0.003). CONCLUSION: We found high prevalence of S. mansoni and PPF in the HIV infected population and age was a significant factor for PPF. We recommend all HIV infected patients be examined routinely for S. mansoni infection for early anti-schistosomal treatment.


Subject(s)
Coinfection/epidemiology , HIV Infections/complications , Liver Cirrhosis/etiology , Schistosomiasis mansoni/complications , Adolescent , Adult , Aged , Animals , Coinfection/parasitology , Coinfection/virology , Cost of Illness , Cross-Sectional Studies , Female , HIV Infections/epidemiology , Humans , Liver Cirrhosis/epidemiology , Liver Cirrhosis/parasitology , Liver Cirrhosis/virology , Male , Middle Aged , Risk Factors , Rural Population/statistics & numerical data , Schistosoma mansoni , Schistosomiasis mansoni/epidemiology , Uganda/epidemiology , Young Adult
3.
Pan Afr Med J ; 24: 296, 2016.
Article in English | MEDLINE | ID: mdl-28154651

ABSTRACT

INTRODUCTION: Severe chronic hepatic schistosomiasis is a common cause of episodes upper gastrointestinal bleeding (UGIB) in sub-Saharan Africa (SSA). However, there is paucity of data on clinical epidemiology of episodes of UGIB from rural Africa despite on going public health interventions to control and eliminate schistosomiasis. METHODS: Through a cross sectional study we profiled lifetime episodes of upper gastrointestinal bleeding and associated factors at a rural primary health facility in sub-Saharan Africa were schistosomiasis is endemic. The main outcome was number of lifetime episodes of UGIB analyzed as count data. RESULTS: From 107 enrolled participants, 323 lifetime episodes of UGIB were reported. Fifty-seven percent experienced ≥ 2 lifetime episodes of UGIB. Ninety-four percent had severe chronic hepatic schistosomiasis and 80% esophageal varices. Alcohol use and viral hepatitis was infrequent. Eighty-eight percent were previously treated with praziquantel and 70% had a history of blood transfusion. No patient had ever had an endoscopy or treatment for prevention of recurrent variceal bleeding. Multivariable analysis identified a cluster of eight clinical factor variables (age ≥ 40, female sex, history of blood transfusion, abdominal collaterals, esophageal varices, pattern x periportal fibrosis, anemia, and thrombocytopenia) significantly associated (P-value < 0.05) with increased probability of experiencing two or more lifetime episodes of UGIB in our study. CONCLUSION: Upper gastrointestinal bleeding is a common health problem in this part of rural SSA where schistosomiasis is endemic. The clinical profile described is unique and is important for improved case management, and for future research.


Subject(s)
Esophageal and Gastric Varices/epidemiology , Gastrointestinal Hemorrhage/epidemiology , Schistosoma mansoni/isolation & purification , Schistosomiasis/epidemiology , Adult , Africa South of the Sahara/epidemiology , Animals , Cross-Sectional Studies , Endemic Diseases , Esophageal and Gastric Varices/complications , Female , Gastrointestinal Hemorrhage/etiology , Humans , Male , Middle Aged , Multivariate Analysis , Risk Factors , Rural Population , Schistosomiasis/complications
SELECTION OF CITATIONS
SEARCH DETAIL
...