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1.
Clin Otolaryngol ; 48(2): 151-157, 2023 03.
Article in English | MEDLINE | ID: mdl-36268807

ABSTRACT

OBJECTIVE: To evaluate the effect of Neurotec® herbal capsule (100 mg twice a day for 3 months) on the tinnitus symptoms in comparison with the placebo. DESIGN: A double-blind randomised clinical trial. SETTING: Otolaryngology clinic of Baqiyatallah Hospital. PARTICIPANTS: Patients suffering from subjective tinnitus. MAIN OUTCOME MEASURES: Pure tone audiometry was measured at .5, 1, 2, 4 and 6 kHz frequencies before and after the third month of intervention. In addition, Tinnitus Handicap Inventory (THI) questionnaire as well as visual analogue scale (VAS) for tinnitus loudness, daily annoyance, daily life or sleep disturbance, daily perception and mood alteration were evaluated. RESULTS: Finally, 103 (69 males and 34 females) patients with a mean age of 51.33 ± 13.91 years were analysed. In contrast with control group, patients in intervention group showed a remarkable decrease in THI score after 3 months of treatment (p < .05). Although both groups had improvements in VAS scores, mood disturbance, daily tinnitus perception and daily life alteration scores were only improved in the intervention group. The mean pure tone air and bone conduction were not significantly different between the control and the intervention group at baseline and 3 months after the intervention at .5, 1, 2 and 4 kHz (p > .05). CONCLUSION: A 3-month treatment with Neurotec capsules in addition to patient education is of benefit for managing symptoms in patients with chronic tinnitus.


Subject(s)
Rosa , Tinnitus , Urtica dioica , Male , Female , Humans , Adult , Middle Aged , Aged , Tinnitus/diagnosis , Audiometry, Pure-Tone , Visual Analog Scale
2.
Int Tinnitus J ; 21(2): 108-111, 2017 Dec 01.
Article in English | MEDLINE | ID: mdl-29336128

ABSTRACT

OBJECTIVE: To evaluate the effect of PRP-enriched gelfoam on the healing of chronic TM perforation in comparison with gelfoam alone. METHODS: In this double-blind randomized clinical trial Patients with chronic tympanic membrane were randomly allocated to two groups; intervention group underwent tympanoplasty with platelet rich plasma (PRP)- enriched gel foams and control group underwent operation with conventional gel foams alone. Patients information was recorded 4 and 12 months after surgery. RESULTS: Eventually 24 patients (12 males and 12 females) with a mean age of 43.33 ± 12.34 years in intervention and 41.33 ± 10.02 years in control group underwent analysis (p = 0.667). Complete TM healing was seen in 8 (66.67%) patients in intervention group and 3 (25%) patients in control group three months after intervention (p = 0.031, OR = 5.98). CONCLUSION: Addition of PRP to conventional gelfoams used in TM perforation repair increases the complete healing rate of TM perforation with less morbidity and complications.


Subject(s)
Gelatin Sponge, Absorbable/pharmacology , Platelet-Rich Plasma , Tympanic Membrane Perforation/surgery , Tympanic Membrane/diagnostic imaging , Tympanoplasty/methods , Adolescent , Adult , Chronic Disease , Double-Blind Method , Female , Follow-Up Studies , Hemostatics/pharmacology , Humans , Male , Middle Aged , Retrospective Studies , Treatment Outcome , Tympanic Membrane Perforation/diagnosis , Young Adult
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