ABSTRACT
Yasui operation combines Norwood arch reconstruction with Rastelli operation for interrupted or hypoplastic aorta with aortic valvar atresia or hypoplasia with ventricular septal and two adequately sized ventricles, establishing biventricular repair. We present a case of aortic atresia, mitral hypoplasia, and ventricular septal defect (VSD) treated by Yasui procedure, and its long-term (108 months) follow-up and brief review of literature. Review of literature was done using keywords to search on "PubMed" and "Google Scholar." SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12055-021-01174-5.
ABSTRACT
Chyluria presenting as milky white urine is a known presentation. But sudden and recurrent urinary retention without prior history of chyluria is very rare presentation. It also indicates the severity and tendency of passing tissue bits and clots through urine in rare cases. This case was diagnosed because of strong clinical suspicion. This case also highlights the management difficulty in these types of patients as patient had recurrent retention requiring bladder wash & had episodes of chylohematuria with chyle material and clots. This presentation is rare and adds to the list of differential diagnosis of acute retention.
ABSTRACT
A new series of [4-(2-phenylethenesulfonylmethyl)phenyl]quinazolin-4-yl-amines was prepared and tested for its in vitro cytotoxic activity against a panel of 12 human cancer cell lines. Compounds 9, 15, 24 and 31 showed good in vitro activity and were further tested for their in vivo efficacy in the HT-29 human colon adeno carcinoma xenograft model. Compound 9 exhibited promising activity in this model. Dose-response studies for this compound against HT-29 human colon adeno carcinoma xenografts at 100, 200 and 400mg/kg doses were performed.
Subject(s)
Antineoplastic Agents/administration & dosage , Antineoplastic Agents/chemical synthesis , Quinazolines/administration & dosage , Quinazolines/chemical synthesis , Administration, Oral , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical/methods , Female , HT29 Cells , Humans , Mice , Mice, Nude , Xenograft Model Antitumor Assays/methods , Xenograft Model Antitumor Assays/statistics & numerical dataABSTRACT
A series of 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues were synthesized and evaluated for cytotoxic activity against eight human cancer cell lines. Compounds 18, 21, 28, 29, 30 and 31 showed cytotoxic activity with GI(50) values in the range of 2.1-8.1 microM concentration. Among these, compounds 21 and 28 exhibited good pharmacokinetic properties. These compounds were further evaluated for their in vivo efficacy in modified hollow fibre assay (HFA).
Subject(s)
Antineoplastic Agents/chemical synthesis , Indolizines/chemical synthesis , Indolizines/pharmacology , Animals , Antineoplastic Agents/pharmacokinetics , Antineoplastic Agents/pharmacology , Cell Line, Tumor , Cell Survival/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Humans , Indolizines/pharmacokinetics , Mice , Pharmacokinetics , Structure-Activity RelationshipABSTRACT
In our endeavor to design and synthesize novel anticancer agents, a new series of indoloquinazoline compounds were prepared and tested initially for anticancer activity in vitro against a panel of human cancer cell lines. Most of these compounds exhibited cytotoxic activity in in vitro screens. Compounds were selected and further evaluated using a modified Hollow Fiber Assay for their preliminary in vivo activity against 12 cell lines implanted in the subcutaneous and intraperitoneal compartments in mice. The results indicate that these compounds may constitute a new class of anticancer agents.
Subject(s)
Antineoplastic Agents/chemical synthesis , Animals , Antineoplastic Agents/pharmacokinetics , Antineoplastic Agents/pharmacology , Biological Availability , Cell Division/drug effects , Drug Screening Assays, Antitumor , Humans , Indoles/chemistry , Male , Mice , Neoplasms, Experimental/drug therapy , Quinazolines/chemistry , Structure-Activity Relationship , Transplantation, Heterologous , Tumor Cells, CulturedABSTRACT
The results of a Dot immunobinding assay (Dot Iba) for the detection of mycobacterial antigen in the cerebrospinal fluid (CSF) of 45 patients with tuberculous meningitis (TBM) were compared with the results of a polymerase chain reaction (PCR) for the detection of Mycobacterium tuberculosis. In eight patients with culture proven TBM, Dot-Iba gave positive results, while PCR yielded positive results only in six patients. The overall sensitivities of Dot-Iba and PCR in 37 patients with culture negative (probable) TBM were 75.67% and 40.5% respectively. Dot-Iba, in contrast to PCR is a rapid and relatively easier method. More importantly, Dot-Iba is suitable for the routine application for the laboratory diagnosis of TBM and therefore best suited to laboratories in the developing world.
