ABSTRACT
INTRODUCTION: Alterations of serum lipid profiles have been reported widely among Human Immuno deficiency Virus (HIV) positive patients on Highly Active Anti Retroviral Therapy (HAART). However, there are few data on serum lipid profile among treatment naïve HIV positive patients in our environment. OBJECTIVES: To describe the pattern of lipid profile among treatment naïve HIV positive patients and changes following HAART initiation. METHODS: One hundred and thirty HIV positive patients seen in HIV center in an urban area in Nigeria and 44 matched individuals were recruited. Data were collected on socio demographic characters, baseline lipid profiles and CD4 count. Values of lipid parameters were retrieved after 12 months on HAART. RESULTS: The mean Low density lipoprotein(LDL) was 2.26+ 0.9 mmol/l among the test group compared with 0.96+0.39 mmol/L among the control, p value=0.000. The mean High density lipoprotein (HDL) was also significantly lower, 0.8+0.6 mmol/L reaching a dyslipidemic level, in the HIV positive group than the control, p value = 0.00. Tuberculosis/HIV co infected patients had a significantly elevated mean LDL, p=0.002. CONCLUSION: Abnormality of serum lipid is common among treatment naïve HIV patients seen in Nigeria. The NNRTI regimen is associated with elevation of HDL and some stabilization of TC and TG.
Subject(s)
Acquired Immunodeficiency Syndrome/drug therapy , Antiretroviral Therapy, Highly Active/adverse effects , Dyslipidemias/etiology , HIV Infections/drug therapy , Lipids/blood , Acquired Immunodeficiency Syndrome/blood , Acquired Immunodeficiency Syndrome/complications , Adult , Anti-HIV Agents/therapeutic use , Body Mass Index , CD4 Lymphocyte Count , Case-Control Studies , Cross-Sectional Studies , Dyslipidemias/complications , Female , HIV Infections/blood , HIV Infections/complications , Humans , Male , Middle Aged , Nigeria , Risk Factors , Socioeconomic Factors , Young AdultABSTRACT
Introduction: Alterations of serum lipid profiles have been reported widely among Human Immuno deficiency Virus (HIV) positive patients on Highly Active Anti Retroviral Therapy (HAART). However; there are few data on serum lipid profile among treatment na?ve HIV positive patients in our environment. Objectives: To describe the pattern of lipid profile among treatment na?ve HIV positive patients and changes following HAART initiation. Methods: One hundred and thirty HIV positive patients seen in HIV center in an urban area in Nigeria and 44 matched individuals were recruited. Data were collected on socio demographic characters; baseline lipid profiles and CD4 count. Values of lipid parameters were retrieved after 12 months on HAART. Results: The mean Low density lipoprotein(LDL) was 2.26+ 0.9 mmol/l among the test group compared with 0.96+0.39mmol/L among the control ;p value =0.000 .The mean High density lipoprotein (HDL) was also significantly lower;0.8+ 0.6mmol/L reaching a dyslipidemic level; in the HIV positive group than the control; p value = 0.00. Tuberculosis /HIV co infected patients had a significantly elevated mean LDL; p=0.002. Conclusion: Abnormality of serum lipid is common among treatment na?ve HIV patients seen in Nigeria. The NNRTI regimen is associated with elevation of HDL and some stabilization of TC and TG
Subject(s)
Acquired Immunodeficiency Syndrome , HIV Infections , Lipids , NigeriaABSTRACT
Sera of forty insulin-treated Nigerian diabetics attending the outpatients clinic of the University College Hospital (U.C.H.), Ibadan, and an equal number of non-diabetic control subjects matched for age, sex and social status were tested for presence of complement fixing (CF) antibodies against five viruses: Coxsackie A and B1, mumps rubella and enterovirus group antigen. Antibody levels to Coxsackie B1, mumps, rubella and enterovirus did not show any significant difference between the two groups (P > 0.05). The serum levels of antibody to Coxsackie A virus were significantly higher in non-diabetic controls than in the diabetics (P < 0.05). Previous exposure to these viruses may not be a significant factor in the aetiology of insulin dependent diabetes mellitus in this environment.
Subject(s)
Antibodies, Viral/blood , Complement System Proteins/analysis , Diabetes Mellitus, Type 1/immunology , Complement Fixation Tests , Diabetes Mellitus, Type 1/etiology , Humans , Nigeria , Virus Diseases/complications , Virus Diseases/immunologyABSTRACT
A case of severe congestive cardiac failure of unidentified etiology demonstrating an extreme electrical QRS axis is presented. The axis is about -120 degrees. This electrocardiographic manifestation is rare, and, to the best of our knowledge, there have been no previously reported cases in congestive cardiac failure in our environment. This finding, in view of the clinical state of our patient, may be indicative of extreme severity resulting in widespread patchy myocardial fibrosis.
