Atomic-Scale Multimodal Characterization of Self-Assembled InAs/InGaAlAs Quantum Dots.

Self-assembled quantum dots (QDs) are potential candidates for photoelectric and photovoltaic devices, because of their discrete energy levels. The characterization of QDs at the atomic level using a multimodal approach is crucial to improving device performance because QDs are nanostructures with highly correlated structural parameters. In this study, scanning transmission electron microscopy, geometric phase analysis, and atom probe tomography were employed to characterize structural parameters such as the shape, strain, and composition of self-assembled InAs-QDs with InGaAlAs spacer layers. The measurements revealed characteristic AlAs-rich regions above the QDs and InAs-rich regions surrounding the QD columns, which can be explained by the relationship between the effect of strain and surface curvature around the QD. The methodology described in this study accelerates the development of future QD devices because its multiple perspectives reveal phenomena such as atomic-scale segregations and allow for more detailed discussions of the mechanisms of these phenomena.

Temperature-independent lasing wavelength of highly stacked InAs quantum dot laser fabricated on InP(311)B substrate with Bi irradiation.

In this study, the effects of bismuth (Bi) irradiation on InAs quantum dot (QD) lasers operating in the telecommunication wavelength band were investigated. Highly stacked InAs QDs were grown on an InP(311)B substrate under Bi irradiation, and a broad-area laser was fabricated. In the lasing operation, the threshold currents were almost the same, regardless of Bi irradiation at room temperature. These QD lasers were operated at temperatures between 20 and 75°C, indicating the possibility of high-temperature operation. In addition, the temperature dependence of the oscillation wavelength changed from 0.531 nm/K to 0.168 nm/K using Bi in the temperature range 20-75°C.

Fiber-terahertz-fiber bridge system in the 355-GHz band using a simple optical frequency comb and a photonics-enabled receiver.

This Letter demonstrates a high-speed fiber-terahertz-fiber system in the 355-GHz band using stable optical frequency comb generation and a photonics-enabled receiver. At the transmitter, a single dual-drive Mach-Zehnder modulator is employed to generate a frequency comb by driving the modulator under an optimal condition. At the antenna site, a photonics-enabled receiver consisting of an optical local oscillator signal generator, a frequency doubler, and an electronic mixer is used to downconvert the terahertz-wave signal to the microwave band. Simple intensity modulation and a direct detection method are used for transmitting the downconverted signal to the receiver over the second fiber link. To demonstrate the proof of concept, we transmitted a 16-quadrature amplitude modulation (QAM) orthogonal frequency-division multiplexing signal over a system consisting of two radio-over-fiber links and a 4 m wireless link in the 355-GHz band and achieved a line rate of 60 Gb/s. We also successfully transmitted a 16-QAM subcarrier multiplexing single-carrier signal over the system and achieved a capacity of 50 Gb/s. The proposed system can facilitate the deployment of ultra-dense small cells in high-frequency bands in beyond-5G networks.

Fifth-generation new radio millimeter-wave radio signal transmission over a seamless fiber-terahertz mobile fronthaul system for an ultra-dense small cell network.

This Letter demonstrates the transmission of fifth-generation new radio (5G NR) millimeter-wave signals over a seamless fiber-terahertz-wave mobile fronthaul system in the 350 GHz band for an ultra-dense small cell network. The system utilizes a simple optical heterodyne method at the transmitter and direct detection at the receiver. As a proof-of-concept demonstration, we successfully transmitted 256- and 64-quadrature amplitude modulation 5G-NR-compliant signals at 24.2 and 38 GHz over a seamless fiber-terahertz system in the 350 GHz band. The proposed system can provide a simple solution to facilitate the deployment of ultra-dense small cells in high-frequency bands in 5G networks and beyond.

Fast dynamics of low-frequency fluctuations in a quantum-dot laser with optical feedback.

We experimentally investigate the complex dynamics of a multi-mode quantum-dot semiconductor laser with time-delayed optical feedback. We examine a two-dimensional bifurcation diagram of the quantum-dot laser as a comprehensive dynamical map by changing the injection current and feedback strength. We found that the bifurcation diagram contains two different parameter regions of low-frequency fluctuations. The power-dropout dynamics of the low-frequency fluctuations are observed in the sub-GHz region, which is considerably faster than the conventional low-frequency fluctuations in the MHz region. Comparing the dynamics of quantum-dot laser with those of single- and multi-mode quantum-well semiconductor lasers reveals that the fast low-frequency fluctuation dynamics are unique characteristics of quantum-dot lasers with time-delayed optical feedback.

Effects of non-exciton components excited by broadband pulses on quantum beats in a GaAs/AlAs multiple quantum well.

In this study, we report the effect of the excitation of non-exciton components caused by broadband pulses on quantum beat oscillation. Using a spectrally controlled pump pulse, a long-lived oscillation is clearly observed, and the pump-power dependence shows the suppression of the dephasing rate of the oscillation. Our results from incoherent carrier generation using a continuous wave laser demonstrate that the non-exciton components behaving as free carriers increase the oscillation dephasing rate.

Strategy of Daiichi Sankyo discovery research in oncology.

We would like to introduce Daiichi Sankyo's approach to developing cancer targeted medicines with special reference to the drug discovery strategy, global discovery activities and external research collaboration leading to generation of innovative drugs for cancer patients. We are developing 14 clinical projects for cancer treatment and three of them have been previously approved. These are mostly targeted for growth and survival signals of cancer cells. To overcome the drug resistance mechanism derived from the heterogeneous nature of cancer, we are developing selective inhibitors in three major clusters of signal pathways which may allow future rational combinations of oncology products. In addition to the main research facility in Japan, research sites in the EU and the USA provide us with different technical expertise and diversified ideas of drug discovery. To access novel drug targets, we are facilitating research collaboration with leading academia and successful cancer research scientists. In conclusion, we intend to focus more on developing innovative personalized medicines for better treatment of cancer.

Simultaneous multichannel wavelength multicasting and XOR logic gate multicasting for three DPSK signals based on four-wave mixing in quantum-dot semiconductor optical amplifier.

In this paper, we experimentally demonstrate simultaneous multichannel wavelength multicasting (MWM) and exclusive-OR logic gate multicasting (XOR-LGM) for three 10Gbps non-return-to-zero differential phase-shift-keying (NRZ-DPSK) signals in quantum-dot semiconductor optical amplifier (QD-SOA) by exploiting the four-wave mixing (FWM) process. No additional pump is needed in the scheme. Through the interaction of the input three 10Gbps DPSK signal lights in QD-SOA, each channel is successfully multicasted to three wavelengths (1-to-3 for each), totally 3-to-9 MWM, and at the same time, three-output XOR-LGM is obtained at three different wavelengths. All the new generated channels are with a power penalty less than 1.2dB at a BER of 10(-9). Degenerate and non-degenerate FWM components are fully used in the experiment for data and logic multicasting.

High net modal gain (>100 cm(-1)) in 19-stacked InGaAs quantum dot laser diodes at 1000 nm wavelength band.

An InGaAs quantum dot (QD) laser diode with 19-stacked QDs separated by 20 nm-thick GaAs spacers was fabricated using an ultrahigh-rate molecular beam epitaxial growth technique, and the laser characteristics were evaluated. A 19-stacked simple broad area QD laser diode was lased at the 1000 nm waveband. A net modal gain of 103 cm(-1) was obtained at 2.25 kA/cm(2), and the saturated modal gain was 145.6 cm(-1); these are the highest values obtained to our knowledge. These results indicate that using this technique to highly stack QDs is effective for improving the net modal gain of QD lasers.

Discovery of novel Thieno[2,3-d]pyrimidin-4-yl hydrazone-based cyclin-dependent kinase 4 inhibitors: synthesis, biological evaluation and structure-activity relationships.

The design, synthesis, and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitors are described. In continuing our program aim to search for potent CDK4 inhibitors, the introduction of a thiazole group at the hydrazone part has led to marked enhancement of chemical stability. Furthermore, by focusing on the optimization at the C-4' position of the thiazole ring and the C-6 position of the thieno[2,3-d]pyrimidine moiety, compound 35 has been identified with efficacy in a xenograft model of HCT116 cells. In this paper, the potency, selectivity profile, and structure-activity relationships of our synthetic compounds are discussed.

Narrow-line-width 1.31-µm wavelength tunable quantum dot laser using sandwiched sub-nano separator growth technique.

A wide wavelength tunable quantum dot (QD) external cavity laser operating in the 1.31-µm waveband with a narrow line-width is successfully demonstrated. A high-density, high-quality InAs/InGaAs QD optical gain medium for the 1.31-µm waveband was obtained using a sandwiched sub-nano separator growth technique. A wide wavelength tunability of 1.265-1.321 µm and a narrow line-width of 210 kHz were successfully achieved using a compact and robust external cavity system constructed with multiple optical band-pass and etalon filters for active optical mode selection. The laser also achieved an error-free 10-Gb/s photonic data transmission over an 11.4-km-long holey fiber.

Simultaneous 3 x 10 Gbps optical data transmission in 1-mum, C-, and L-wavebands over a single holey fiber using an ultra-broadband photonic transport system.

An ultra-broadband photonic transport system has been developed to expand the usable wavelength bandwidth for optical communication. Simultaneous 3 x 10-Gbps error-free photonic transmissions are demonstrated in the 1-microm, C-, and L-wavebands by using the ultra-broadband photonic transport system over a 5.4-km-long holey fiber transmission line.

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of cyclin D1-CDK4: synthesis, biological evaluation and structure-activity relationships. Part 2.

The design, synthesis and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitor are described. Focusing on the optimization of the heteroaryl moiety at the hydrazone with substituted phenyl groups, 4-[(methylamino)methyl]benzaldehyde (22) and 5-isoindolinecarbaldehyde (24) (6-tert-butylthieno[2,3-d]pyrimidin-4-yl)hydrazone derivatives have been identified. In this paper, the potency, selectivity profile and structure-activity relationships of our synthetic compounds are discussed.

10-Gbps, 1-microm waveband photonic transmission with a harmonically mode-locked semiconductor laser.

To open up a 1-microm waveband for photonic transport systems, we developed a hybrid and harmonically mode-locked semiconductor laser (MLL) that can transmit return-to-zero (RZ) optical signals at data rates on the order of gigabits per second. A single-mode hole-assisted fiber (HAF) was also developed for use as a 1-microm waveband signal transmission line. A stable optical pulse train with a repetition rate of 9.953 GHz, pulse width of 22 ps, and low timing jitter of 120 fs was obtained from a 1035-nm harmonically MLL. With these devices, we successfully demonstrated 1-microm waveband error-free transmission of a high-speed 10-Gbps RZ signal over a long distance of 7 km.

Anticancer drugs that induce cancer-associated cachectic syndromes.

Cachexia--a wasting condition--seriously impairs the quality of life of patients with advanced cancer. Previous studies have shown that several inflammatory cytokines mediate the development of cancer-associated cachexia. Experimentally, cachexia-like symptoms can be induced in tumor-bearing mice and treatment of such mice with chemotherapeutic agents reverses cachexia as a result of its therapeutic action. Nonetheless, cancer chemotherapy occasionally induces anorexia as an adverse reaction. For example, treatment with antitubulin taxanes reduces body weight in tumor-bearing mice more than healthy mice, even when the agents significantly reduce tumor growth. However, the complex relationship between cancer cachexia and the effects of anticancer drugs remains to be elucidated. This review outlines what is known about the development of cachectic reactions, especially in tumor-bearing mice, that occur during treatment with anticancer agents and highlights the clinical relevance of the information.