ABSTRACT
Pure lipoma of the uterus is a rare clinical event, and only a few cases have been reported in the literature. Clinical symptoms and physical signs are similar to those found in leiomyomas. The histogenesis of these lesions is still unclear. However, adipose metaplasia of stromal cells or smooth muscle cells of leiomyoma were accepted hypothesis that explain histogenesis of lipomas of uterus. We report the case of a 55-year-old woman with pure uterine lipoma and coincidental cancer of uterine cervix.
Subject(s)
Carcinoma, Squamous Cell/pathology , Cell Transformation, Neoplastic/pathology , Lipoma/pathology , Neoplasms, Multiple Primary/pathology , Uterine Cervical Neoplasms/pathology , Uterine Neoplasms/pathology , Biopsy, Needle , Carcinoma, Squamous Cell/surgery , Female , Follow-Up Studies , Humans , Hysterectomy/methods , Immunohistochemistry , Incidental Findings , Lipoma/surgery , Middle Aged , Neoplasms, Multiple Primary/surgery , Risk Assessment , Treatment Outcome , Uterine Cervical Neoplasms/surgery , Uterine Neoplasms/surgeryABSTRACT
BACKGROUND: Accidental intrathecal vincristine (VCR) administration results in severe neurotoxicity, usually fatal in outcome. No specific therapy for initrathecal VCR toxicity has been reported so far. In our recent report, complete in vitro degradation of VCR by hypochlorous acid (HOCl) was demonstrated. METHODS: In this comparative study, we examined the in vivo effectiveness of HOCl in the cerebrospinal fluid of 24 New Zealand rabbits following intracisternal VCR administration. RESULTS: There were no significant clinical or histopathologic abnormalities in the control and HOCl groups; however, multiple necrotic foci on histopathological examination of brain sections in the VCR group were determined. There were significantly lower numbers of necrotic foci in brain sections of rabbits which received HOCl administration than those without therapy. CONCLUSION: Our results indicate that HOCl may reduce VCR neurotoxicity.
