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1.
Epilepsy Behav ; 23(4): 481-6, 2012 Apr.
Article in English | MEDLINE | ID: mdl-22386912

ABSTRACT

RATIONALE: The purposes of this study were to 1) conduct a review of neuropsychological (NP) outcomes after epilepsy surgery for DNET and 2) present pre/post-surgical NP results from a series of children with DNET. METHODS: First, a systematic literature review was conducted with specific inclusion criteria. Second, a review of DNET surgical patients seen at two tertiary-care hospitals using reliable change methods of NP functioning was conducted. RESULTS: Of 300 citations retrieved, 7 studies met criteria. Studies reported low average to average pre-surgical IQ. Engel Class I outcome was approximately 85%. CASE SERIES: Thirteen children completed pre/post-surgical NP assessments. Pre-surgically, children demonstrated low average to average functioning. Post-surgically, few patients showed reliable change. One-third of children demonstrated psychological improvement. CONCLUSIONS: NP outcome following DNET has not been well-described. Children with DNET demonstrate low average to average NP functioning pre-surgically, good seizure outcome, and stable NP functioning post-surgically.


Subject(s)
Cognition Disorders/surgery , Epilepsy/surgery , Neoplasms, Neuroepithelial/surgery , Teratoma/surgery , Adolescent , Child , Child, Preschool , Cognition Disorders/etiology , Epilepsy/complications , Female , Humans , Male , Neoplasms, Neuroepithelial/complications , Neuropsychological Tests , Pediatrics , Retrospective Studies , Teratoma/complications , Treatment Outcome
2.
Epilepsy Behav ; 19(3): 428-35, 2010 Nov.
Article in English | MEDLINE | ID: mdl-20926354

ABSTRACT

Children with epilepsy have a high rate of attention deficit/hyperactivity disorder (ADHD), yet parent-teacher agreement on ADHD symptoms in epilepsy is unknown despite the need to assess symptoms across settings such as home and school. Parent-teacher agreement on ADHD ratings was investigated in 208 children with epilepsy (mean age = 11.2, SD = 3.6) using the ADHD Rating Scale IV, along with associations with demographic variables, epilepsy severity, adaptive level, and quality of life. Children were four times more likely to be identified as having clinically elevated ADHD symptoms when parent ratings were the benchmark versus teachers. Agreement was highest for children with more severe ADHD symptoms, for the Hyperactivity-Impulsivity dimension of behavior, and for children with broadly normal adaptive behavior. Higher parent and teacher ADHD ratings were related to reduced quality of life, but unrelated to epilepsy severity. Exclusive reliance on parent or teacher ratings may yield variable rates of ADHD symptoms in children with epilepsy.


Subject(s)
Attention Deficit Disorder with Hyperactivity/diagnosis , Epilepsy/diagnosis , Faculty , Parents/psychology , Adaptation, Psychological , Adolescent , Attention Deficit Disorder with Hyperactivity/epidemiology , Child , Child, Preschool , Epilepsy/epidemiology , Female , Humans , Male , Prevalence , Psychiatric Status Rating Scales , Seveso Accidental Release , Statistics as Topic , Young Adult
3.
Epilepsy Behav ; 12(1): 96-101, 2008 Jan.
Article in English | MEDLINE | ID: mdl-17974486

ABSTRACT

In most chronic conditions, better health-related quality of life (HRQOL) is associated with higher socioeconomic status (SES) and ethnic majority status, with disadvantaged groups typically reporting lower HRQOL. In 163 children with intractable epilepsy, we evaluated the relationship between HRQOL and a broad spectrum of demographic variables (SES, parental education, gender, age, marital status, family size, and ethnic and linguistic status), in relation to known neurological and behavioral correlates of HRQOL. No demographic variable was found to be related to child HRQOL, except for marital status, where children from divorced/separated parents had lower HRQOL. However, marital status was not uniquely predictive of HRQOL when neurological and behavioral variables were taken into account. Exploratory analyses indicated that children of separated/divorced parents were more likely to have early epilepsy onset, lower adaptive/developmental levels, and worse seizure frequency, suggesting that severe epilepsy may be a risk factor for marital stress. In sum, contrary to research in other chronic conditions, sociodemographic variables in pediatric epilepsy were weak predictors of HRQOL in comparison to neurological and behavioral variables. The results are discussed with respect to epilepsy-specific determinants of HRQOL.


Subject(s)
Epilepsy/psychology , Health Status , Pediatrics , Quality of Life , Socioeconomic Factors , Adolescent , Adult , Anticonvulsants/supply & distribution , Anticonvulsants/therapeutic use , Child , Epilepsy/drug therapy , Female , Health Status Indicators , Humans , Male , Regression Analysis
4.
Schizophr Res ; 64(2-3): 165-73, 2003 Nov 15.
Article in English | MEDLINE | ID: mdl-14613681

ABSTRACT

Schizophrenia has long been associated with abnormal patterns of arousal that are thought to reflect disturbances in the reticular-activating system of the brain. Psychophysiological investigations of sensory responsivity have repeatedly demonstrated reduced reactivity and habituation to moderately intense stimuli in patients with schizophrenia. While not traditionally used as a measure of physiological arousal, the startle reflex represents an alternative method for studying reactivity and habituation in schizophrenia. This study examined eye blink responsivity to a repeatedly presented intense acoustic startle probe in men with chronic schizophrenia and healthy normal controls. Subjects' personality profiles were also measured, as increased reactivity and arousal have been traditionally implicated as a physiological component to the personality trait of neuroticism. Results indicated that schizophrenic subjects did demonstrate significantly reduced rates of habituation to the acoustic startle probe and higher scores on measures of neuroticism in comparison to normal controls. However, no correlation between habituation rate and neuroticism emerged. These studies replicate previous findings of habituation in schizophrenia and provide further evidence for sensory reactivity disturbances in schizophrenia. The relationship of these findings to cognitive disturbances in schizophrenia is considered and directions for future research are discussed.


Subject(s)
Arousal/physiology , Blinking/physiology , Habituation, Psychophysiologic/physiology , Personality Inventory , Reflex, Startle/physiology , Schizophrenia/physiopathology , Schizophrenic Psychology , Acoustic Stimulation , Adult , Chronic Disease , Electromyography , Female , Humans , Loudness Perception/physiology , Male , Middle Aged , Personality Inventory/statistics & numerical data , Psychiatric Status Rating Scales , Psychometrics , Psychophysiology , Schizophrenia/diagnosis , Statistics as Topic
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