The effects of etomidate on testicular ischemia reperfusion injury in ipsilateral and contralateral testes of rats.

OBJECTIVE: Testicular torsion is a condition that manifests with acute pain and can lead to infertility despite urgent surgical intervention. The aim of this study is to investigate the protective and preventive effects of etomidate, an imidazole derivative, a non-barbiturate general anesthetic agent, without analgesic effect, on testicular ischemia-reperfusion injury. MATERIALS AND METHODS: Twenty-four adult male Wistar rats weighing 200-250 g were used in the study. Torsion was created in all rats by rotating left testes 720° clockwise on the day of the experiment. 30 minutes before detorsion, 4 mg/kg etomidate and 10 mg/kg propofol were administered intraperitoneally to the etomidate and propofol groups, respectively. After an hour of ischemia, the left testis was reinstated, and the tissues were repaired according to their physiology. Following 24 hours of reperfusion, the animals were euthanized after ipsilateral and contralateral testes were removed. RESULTS: Etomidate applied before testicular detorsion significantly suppressed germ cell damage and Leydig cell loss in ipsilateral tissue. It did not cause any significant changes in the percentage of necrosis, histological score, and tubule rupture in ipsilateral tissue. Propofol administered before testicular detorsion significantly suppressed the percentage of necrosis only in the ipsilateral tissue. In addition, no signs of damage were observed in the contralateral testis. CONCLUSIONS: These findings show that etomidate administered before detortion creates a protective effect by preventing testicular ischemia-reperfusion injury.

A histopathological and stereological study of liver damage in female rats caused by mercury vapor.

We examined the possible effects of elemental mercury vapor on the liver of the female rats. We divided the animals into an untreated control group and an experimental group that was exposed to mercury vapor for 45 days. Liver samples were obtained for histological and stereological analysis. The total liver, parenchyma and sinusoid volumes were increased significantly in the mercury vapor treated group compared to controls. Also, the mean density, total number and mean nuclear diameter of hepatocytes, except for binucleated hepatocytes, was decreased in the experimental group compared to controls. Light and electron microscopy revealed alterations of liver structure of the experimental animals compared to controls.

Ectopic Premolar Tooth in the Sigmoid Notch.

Impaction of a mandibular premolar is relatively uncommon. Ectopic placement is more unusual and there has been no discussion in the literature of an ectopic mandibular premolar in the coronoid process. In this case report, we present an impacted ectopic mandibular permanent premolar in the sigmoid notch (incisura mandibulae) region. Etiology of the tooth and treatment options are discussed and illustrated by Cone Beam Computed Tomography (CBCT) images.

A stereological and histopathological study of the effects of exposure of male rat testes to mercury vapor.

Mercury is ubiquitous in the environment; it is an occupational pollutant and a potential toxicant. We investigated the effects of exposure of rat testes to mercury vapor (Hg(0)). Twelve male rats were divided into two groups of six: the rats of the Hg(0) group were exposed to mercury (1 mg/m(3)/day) in a chamber for six weeks; the control group rats were housed under the same conditions without exposure to Hg(0). After the experimental period, the testes were removed, sections of testis were evaluated histopathologically after hematoxylin and eosin staining, and stereologically using the Cavalieri principle and optical fractionator methods. We found significant decreases in the total volume of testis, diameters of seminiferous tubules and total volume of seminiferous tubules. Significant decreases were detected in the numbers of Sertoli cells, spermatogonia, spermatocytes and spermatids of the Hg(0) group compared to the control group. In the Hg(0) exposed group, spermatogenic cells were degenerated and seminiferous tubules were atrophied.

Radiological examination of the articular eminence morphology using cone beam CT.

OBJECTIVE: The purpose of the present study was to investigate the articular eminence inclination and height according to age and gender in patients with temporomandibular joint (TMJ) dysfunction and healthy controls using cone beam CT (CBCT). METHODS: The measurements were performed on CBCT records of 52 TMJ dysfunction patients (11 males and 41 females) and 41 control patients (17 males and 24 females). The eminence inclination and height were measured on the CBCT images. RESULTS: The eminence inclination and height values were higher in males than in females in both TMJ dysfunction patient and control groups; however, these differences were not statistically significant (p>0.05). While no statistically significant differences were found in the eminence inclination and height values between the age groups (p>0.05) in the TMJ dysfunction patient group, there were statistically significant differences in the control group. The eminence inclination was highest between the ages of 21 and 30 years and showed a decrease after the age of 30 years. Additionally, the eminence inclinations of the control patients were statistically higher than those of the TMJ dysfunction patients. CONCLUSION: There were no statistically significant differences in eminence inclination and height according to gender. The eminence inclination reaches its highest value between the ages of 21 and 30 years and shows a decrease after the age of 31 years in healthy patients. The eminence inclination was steeper in healthy control patients than in patients with TMJ dysfunction.

Evaluation of enamel pearls by cone-beam computed tomography (CBCT).

OBJECTIVE: The aim of this study was to evaluate the frequency of enamel pearls according to population, sex and tooth groups on Cone-Beam Computed Tomography (CBCT) or Dental Volumetric Tomography (DVT) scans of patients, retrospectively. STUDY DESIGN: In this study, 15185 teeth belonging to 768 patients, 430 female and 338 male, was performed cross-sectional examination by CBCT. The volumetric Computed Tomography used in the study is Newton FP based on flat-panel. The data were analyzed with Pearson chi-squared test. RESULTS: Enamel pearls were detected in 36 subjects (4.69%). Of these enamel pearls, 19 were detected in male and 17 were in male. There was no statistically a significant association between prevalence of enamel pearls and sex. All of enamel pearls were detected in molar teeth, for prevalence 0.83%. CONCLUSION: All of enamel pearls are found upper and lower molar teeth, especially the most commonly in maxillary second and third molars.

Pneumatization of the articular eminence on cone beam computed tomography: prevalence, characteristics and a review of the literature.

OBJECTIVES: The aim of this study was to determine the prevalence and characteristics of pneumatized articular eminence (PAT) by cone beam CT (CBCT) and to present a review of the PAT literature. METHODS: A retrospective study was performed using sagittal and coronal CBCT images of 514 patients in the Department of Oral and Maxillofacial Radiology, Ataturk University, Turkey. Age and gender were recorded for all patients and, for the cases of PAT, laterality and types were also recorded. The χ(2) test was used. RESULTS: Of the 514 patients, 41 (8.0%) had PAT, of whom 25 were female (61.0%) and 16 were male (39.0%). This difference was not statistically significant (P > 0.05). The age range of the patients with PAT was 15-62 years (mean 30.6 ± 11.4). Of the 41 patients, 31 (75.6%) had unilateral and 10 (24.4%) had bilateral PAT. 17 (41.5%) PATs were unilocular and 24 (58.5%) were multilocular. CONCLUSIONS: It is possible that PAT is a more frequent condition than is commonly perceived. In differential diagnosis of suspected cases or in cases for which surgical treatment is planned, panoramic radiographs should be supplemented with CBCT.

Relationship between mandibular nutrient canals and hypertension.

This study was undertaken to investigate the correlation between the presence of nutrient canals in the mandibular anterior region and hypertension. Periapical radiographs taken from the mandibular anterior region of 139 normotensive and 76 hypertensive edentulous patients were examined. There was no statistical difference in the incidence of nutrient canals between normotensive and hypertensive patients, suggesting that the presence of nutrient canals is not indicative of the existence of hypertension.

Evaluation of the mandible as an alternative autogenous bone source for oral and maxillofacial reconstruction.

The objective of this study was to quantify the amount of bone graft material present in the different regions of the mandible while avoiding the inferior alveolar neurovascular bundle, mental foramen and tooth injury. The study was carried out on 16 samples of dry, cadaverous skull. The dimensions of the anterior part of ascending ramus, mandibular symphysis and mandibular body in these samples were evaluated. The osteotomy lines in the anterior part of the ascending ramus were made in front of the mandibular canal from the mandibular notch to 3 mm posterior of the root of the third molar. The osteotomy line in the mandibular body was made just medial to the external oblique ridge from the ascending ramus to approximately 3 mm posterior to the mental foramen. Vertical osteotomy lines were then made from the cut ends of the first osteotomy down to the lower border of the mandible. The osteotomy lines in the mandibular symphysis were performed on the mandible with 5-mm safety margins caudal to the expected position of the mandibular dentition, anterior to the position of the mental foramen, and cephalad to the inferior border of the mandible. It was determined that the dimensions of the anterior part of the ascending ramus were 37.60 mm x 33.17 mm x 22.48 mm x 9.15 mm, and the thickest part of the graft material was 12.23 mm. The average horizontal length of the mandibular body bone was 35.10 mm, and the average vertical length was 19.13 mm. The dimensions of the bone graft obtained from the mandibular symphysis were 45.36 mm x 10.31 mm, and the average thickness was 9.63 mm. Based on the results of this study, it is apparent that the different regions of the mandible can reliably be selected as the harvest site in a variety of oral and maxillofacial reconstructive procedures.

Generalized gingival hyperplasia occurring during pregnancy.

In this report, we present a case of generalized gingival hyperplasia related to pregnancy causing chewing, speaking, breathing and cosmetic problems. The patient was a 26-year-old woman in the fourth month of her second pregnancy, with generalized gingival hyperplasia affecting both buccal and lingual aspects of the maxilla and mandible. The hyperplastic tissues, together with mobile teeth, were excised completely; no recurrence was observed for the remainder of the pregnancy. Hormonal changes occurring during pregnancy have long been known to be associated with generalized gingival hyperplasia. Pregnancy does not cause the condition, but altered tissue metabolism in pregnancy accentuates the response to local irritants. This case was of clinical interest because of the extent of tissue proliferation, with the teeth in both the upper and lower jaw completely submerged.