1.
Org Lett
; 12(5): 988-91, 2010 Mar 05.
Article
in English
| MEDLINE
| ID: mdl-20121257
ABSTRACT
The synthesis of a C1-C19 precursor to pectenotoxin 4 is presented. The strategy employed the functionalized allene shown. Key features include: olefin metathesis of two simple fragments to prepare the left portion of the allene-precursor, diastereoselective propargylation of an epoxy aldehyde to form the right portion, use of the DMDO-stable m-fluorobenzyl ether, and an allene spirodiepoxidation/C-ring formation cascade.
Subject(s)
Epoxy Compounds/chemistry , Macrolides/chemistry , Macrolides/chemical synthesis , Alkadienes/chemistry , Catalysis , Copper/chemistry , Stereoisomerism , Substrate Specificity
2.
J Org Chem
; 66(16): 5585-9, 2001 Aug 10.
Article
in English
| MEDLINE
| ID: mdl-11485487
ABSTRACT
Dimethyldioxirane converted 1-alkylbenzotriazoles 4 to the corresponding 3-alkylbenzotriazole 1-oxides 5 in good yields, but transformed 2-alkylbenzotriazoles 12 into 2-alkyl-trans-4,5,6,7-diepoxy-4,5,6,7-tetrahydrobenzotriazoles 13.