Subject(s)
Anemia, Hypochromic/complications , Iron Deficiencies , Rhinitis, Atrophic/etiology , Rhinoscleroma/etiology , Adolescent , Adult , Female , Humans , Iron/blood , Male , Middle AgedABSTRACT
The study comprised 25 children suffering from PEM. Ten of them were non-oedematous and the rest were oedematous. A group of 10 children of similar age served as the controls. A state of hyperammonaemia with slightly reduced blood urea was found in both forms of PEM but was more marked in kwashiorkor. There was also a highly significant increase in CSF ammonia in all cases of PEM studied. Some of the mental changes which have been observed in kwashiorkor may be, at least in part, due to ammonia intoxication.
Subject(s)
Ammonia/blood , Protein-Energy Malnutrition/blood , Urea/blood , Ammonia/cerebrospinal fluid , Brain/metabolism , Child, Preschool , Female , Humans , Infant , Kwashiorkor/blood , Kwashiorkor/cerebrospinal fluid , Male , Protein-Energy Malnutrition/cerebrospinal fluid , Urea/cerebrospinal fluidABSTRACT
Chloramphenicol a potent inhibitor of bacterial and some mammalian cell protein synthesis, was administered i.p. to a group of mice for 6 consecutive days. Another group of animals was treated similarly with thiamphenicol and a third group served as control. The effects of the two antibiotics on the activity of some liver enzymes; the two pyridoxal 5-phosphate dependent enzymes, kynurenine hydrolase and kynurenine amino-transferase; pyridoxal phosphokinase; beta-glucuronidase and acid ribonuclease were determined. Chloramphenicol and thiamphenicol decreased significantly the activities of kynurenine hydrolase, beta-glucuronidase and acid ribonuclease and both drugs increased the activity of pyridoxal phosphokinase significantly. Their effect on kynurenine amino-transferase was different, chloramphenicol decreased while thiamphenicol increased the enzyme activity. Results are discussed and possible explanations suggested.
