[Perfusion protection of ischemic liver using perfluorocarbon emulsion]. / Perfuzionnaia zashchita ishemizirovannoi pecheni s ispol'zovaniem perftorugliarodnoi émul'sii.

Several concentrations of Fluorocarbon emulsion as means for anti-ischemic protection of the liver were studied in experiments on 47 rabbits with hypothermic perfusion of isolated liver exposed to 90 minute ischaemia. the best concentration of Fluorocarbon emulsion for perfusion of isolated liver was 12%.

[Anti-ischemic protection of the liver using perfluorocarbon emulsion]. / Protivoishemicheskaia zashchita pecheni s primenenium perftoruglerodnoi émul'sii.

Anti-ischemic effectiveness of a Soviet perfluorocarbon emulsion (PFE) was studied in 43 experiments on rabbits with 90-min constriction of the hepatoduodenal ligament and under hypothermic perfusion of the liver during ischemia in the open contour. It has been established that PFE perfusion to a great extent promotes the retention of the ischemized liver function.

[Successive replacement of fatal blood loss in dogs with polyglucin and perfluorocarbon emulsion]. / Posledovatel'noe zameshchenie smertel'noi krovopotere u sobak poligliukinom i émul'siei perftoruglerodov.

The authors studied the hemodynamics and gaseous exchange in dogs after successive replacement of lethal hemorrhage (50 ml/kg bw) by polyglucin and perfluorocarbon emulsion (24 vol/%). The main hemodynamic parameters got recovered and were maintained at the level approaching the initial one during the entire observation period. After blood replacement the pO2 in the artery rose to 500 mmHg, that in the vein to 120 mmHg. The oxygen volume in the blood increased by 3 vol/% on the average. Oxygen consumption also rose. All the animals survived.

[Gas exchange and blood circulation status in dogs following replacement of acute blood loss by perfluoro compound emulsions]. / Gazobmen i sostoianie krovoobrashcheniia u sobak posle zameshcheniia ostroi krovopoteri émul'siei perftorsoedinenii.

Blood circulation and gas exchange were examined after replacement of blood loss (50 ml/kg bw) in dogs by a preparation containing perfluorocompound (PFC) emulsion (20 v. %) and protein-salt solution (PSS) consisting of isotonic solution of electrolytes and donor's albumin, the final concentration of the latter in the preparation being equal to 5%. Animals with analogous blood loss replaced by PSS alone served as control. Infusion of the preparation under study led to a steady recovery of the main parameters of the hemodynamics disordered as a result of blood loss. Its infusion to experimental animals was followed by a noticeable increase in oxygen blood capacity, provoked a more considerable elevation of pO2 in arterial and venous blood as compared to control. Compensation with PFS emulsion for homeostatic changes that occurred in dogs after blood loss involved a more active oxygen utilization, whereas in controls, a more considerable increase of cardiac output. The study drug is offered as base for a blood substitute-oxygen carrier.