Subject(s)
Adaptation, Physiological , Work , Adult , Circadian Rhythm , Hemodynamics , Humans , Middle Aged , Psychophysiology , Saliva/analysis , Time FactorsABSTRACT
The incidence of chromosome aberrations in bone marrow cells of femur did not exceed the spontaneous one in CBA mice exposed, during 70 days, to gamma-radiation at dose--rates of 33.7-35.8 nA/kg and cumulative dose of 2.75 Gy. A single acute exposure of intact animals to a dose of 2.98 Gy increased significantly the mutation level. Preirradiation with small doses increased the resistance of hereditary structures to sublethal radiation doses. Exogenous alpha-tocopherol (0.06 mg/20 g mass) protected the genetic apparatus of cells from total-body irradiation and was an additional factor decreasing the mutation level after acute exposure of mice at the background of long-term irradiation with small doses.
Subject(s)
Bone Marrow/radiation effects , Chromosome Aberrations , Radiation Genetics , Vitamin E/pharmacology , Animals , Bone Marrow/drug effects , Cobalt Radioisotopes , Gamma Rays , Mice , Mice, Inbred CBASubject(s)
Air Microbiology , Bacteria , Containment of Biohazards/methods , Food Handling , Fungi , Soil MicrobiologySubject(s)
Hemodynamics , Laboratories , Myocardial Contraction , Occupational Medicine , Research Personnel , Adult , Electrocardiography , Female , Heart Rate , Humans , Male , Middle Aged , Stress, Psychological/physiopathology , TelemetryABSTRACT
The biological effects of nitrosodimethylamine were studied and compared with the use of biochemical and cytological research methods in different laboratory models. Experiments were made with male and pregnant rats exposed to nitrosodimethylamine in vivo whereupon use was made of embryonic musculocutaneous tissue cell culture in vitro. The same line of changes seen in the activity of lysosomal hydrolases in conjunction with cytochromes P450 and b5 induction in liver chromosomes attests to the existence of common regularities in the biochemical mechanisms of nitrosodimethylamine detoxication in which there participate the endoplasmatic network and lysosomes.
Subject(s)
Dimethylnitrosamine/toxicity , Animals , Cells, Cultured , Embryo, Mammalian/drug effects , Female , Fetal Death/chemically induced , Liver/drug effects , Liver/enzymology , Lysosomes/drug effects , Lysosomes/enzymology , Male , Mice , Pregnancy , Rats , Time FactorsSubject(s)
Antigen-Antibody Reactions/drug effects , Carbaryl/immunology , Animals , Autoantibodies/analysis , Autoantibodies/immunology , Cell Migration Inhibition , Dose-Response Relationship, Immunologic , Epitopes/immunology , Guinea Pigs , Hypersensitivity, Delayed/chemically induced , In Vitro Techniques , Macrophages/drug effects , Macrophages/immunology , RabbitsSubject(s)
Relaxation , Social Medicine , Urban Population , Adolescent , Adult , Azerbaijan , Humans , RecreationSubject(s)
Recreation , Urban Population , Azerbaijan , Facility Design and Construction/trends , Female , Humans , Male , RestABSTRACT
Biological characteristics of 102 Proteus strains isolated from the water bodies is given. The strains studied were referred to Pr. mirabilis, more rarely to Pr. vulgaris; about half of the cultures deviated from these biological types by the signs of indol formation and maltose fermentation. Proteus of groups O3, O5, O13, O23, and O30 were revealed in studying the serological characteristics. All the cultures were polyresistant, nonbacteriocinogenic; most of them were sensitive to the wide colicine spectrum. One strain produced a cytopathogenic action on the tissue culture.
