Adequate iodine levels in healthy pregnant women. A cross-sectional survey of dietary intake in Turkey.

OBJECTIVES: To assess current iodine levels and related factors among healthy pregnant women.  METHODS: In this cross-sectional, hospital-based study, healthy pregnant women (n=135) were scanned for thyroid volume, provided urine samples for urinary iodine concentration and completed a questionnaire including sociodemographic characteristics and dietary habits targeted for iodine consumption at the Department of Obstetrics and Gynecology, School of Medicine,Mugla Sitki Koçman University, Mugla, Turkey, between August 2014 and February 2015. Sociodemographic data were analyzed by simple descriptive statistics. RESULTS: Median urinary iodine concentration was 222.0 µg/L, indicating adequate iodine intake during pregnancy. According to World Health Organization (WHO) criteria, 28.1% of subjects had iodine deficiency, 34.1% had adequate iodine intake, 34.8% had more than adequate iodine intake, and 3.0% had excessive iodine intake during pregnancy. Education level, higher monthly income, current employment, consuming iodized salt, and adding salt to food during, or after cooking were associated with higher urinary iodine concentration.   CONCLUSION: Iodine status of healthy pregnant women was adequate, although the percentage of women with more than adequate iodine intake was higher than the reported literature.

Association between platelet indices and first trimester miscarriage.

We aimed to measure the effect of several potential risk factors on first trimester miscarriage. A total of 169 cases were included in the present study. Patients were selected from women who had first trimester miscarriage (n = 78) and controls were selected from the women who had given birth at term (> 37 weeks of gestation) to healthy infants (n = 91). Compared with the control group, in the miscarriage group gestational age (8.9 ± 2.8 weeks and 8.1 ± 2.2 weeks, respectively, P = 0.032), mean platelet volume (MPV) (8.8 ± 1 and 9.5 ± 1.1 fl, respectively, P < 0.001), plateletcrit (0.209 ± 0.03% and 0.241 ± 0.05%, respectively, P < 0.001), and platelet/lymphocyte ratio (128 ± 37 and 145 ± 60, respectively, P = 0.027) were significantly higher. Multivariate analysis showed that first trimester miscarriage development ratio was 1.909 times higher when MPV value was over 9.1 fl (P < 0.001); 9.147 times higher when plateletcrit value was over 0.219% (P = 0.022). Receiver operating characteristic analysis was performed to determine diagnostic MPV and plateletcrit values for first trimester miscarriage. MPV value greater than 9.1 fl determined miscarriage with 60% sensitivity and 65% specificity, while plateletcrit value greater than 0.219% determined miscarriage with 64.5% sensitivity and 64.7% specificity. MPV and plateletcrit values were strongly associated with first trimester miscarriage. Platelet indices can be used for prediction of fetal loss.