ABSTRACT
Colorectal carcinomas (CRC) were initially thought to be rare in Africa including Nigeria, but recent studies have shown a reverse trend in our environment. This study is aimed to identify the clinical and pathological characteristics of CRC diagnosed between July 2006 and June 2015 in the University of Uyo Teaching Hospital, and a Private Specialist Laboratory, Uyo, Akwa Ibom State, Nigeria. All histological diagnosed cases of CRC seen in the two laboratories (University teaching and a private facility) in Uyo, Akwa-Ibom state, Nigeria during the study period were retrieved noting their bio-data, pathological and clinical variables. A total of 45 patients of age range 26-80 years with a mean of 55.9 years (SD 3.9) and a male to female ratio of 1.4:1 were seen. The two most common age groups affected in CRCs were 61-70 years (28.9%) and 51-60 years (24.4%) respectively. Majority of CRC patients were older than 40 years (86.7%) with identifiable predisposing factors being tubulo-villous adenoma (4 cases, 8.8%), villous adenoma (2 cases 4.4%), polyposis syndromes (2 cases, 4.4%) and schistosomiasis (1 case, 2.2%). Features of large intestinal obstruction were the most common presenting symptom of CRC (53.3%). Rectal bleeding, alteration in bowel habit and fecal incontinence were other symptoms, accounting for 33.3%, 8.9% and 4.4% of cases respectively. Left-sided CRCs were commoner (68.9%) with the majority appearing as annular-constricting type macroscopically (60.0%). Recto-sigmoid region was the preponderant site involved in CRC (29 cases, 64.5%). Adenocarcinoma (84.4%) was the most frequent histological subtype. Mucinous carcinoma, signet ring carcinoma and carcinoid tumor were other histologic subtypes seen in 8.9, 4.4 and 2.2% of cases respectively. The 22.0% of CRC patients presented at advanced stages of the disease. It can be concluded that majority of CRC patients were older than 40 years (86.7%) with features of intestinal obstruction (53.3%) and adenocarcinoma (84.4%) being the predominant mode of clinical presentation and histological subtype respectively.
ABSTRACT
Incidence of gastrointestinal malignancy is gradually increasing. The aim of the study is to investigate age, sex and relative frequencies of various gastrointestinal malignancies diagnosed between January 2007 and December 2014 in the University of Uyo Teaching Hospital, and in a Private Specialist Laboratory, Uyo, Akwa Ibom State, Nigeria. All histological-diagnosed cases of gastrointestinal malignancies seen during the study period were recruited noting their bio-data and histopathological characteristics. A total of 67 patients aged 6-77 years (mean 58.0, SD 7.4) were enrolled; a male to female ratio of 1.3:1 was recorded. The most common age group and anatomical site affected with gastrointestinal malignancy were 61-70 years (23 cases, 34.3%) and colo-rectum cancers (36 cases, 53.7%). The small intestine and stomach were second and third leading anatomic sites involved in gastrointestinal malignancies, accounting for 13 (19.4%) and 8 (11.9%) cases respectively. Adenocarcinoma accounted for the majority of gastrointestinal malignancies (57 cases, 85.1%). Lymphoma and carcinoid tumor were also common, accounting for 3 (4.5%) cases each. Colorectal carcinoma was the most common type of gastrointestinal malignancies (53.7%) with adenocarcinoma being the predominant histological subtype of gastrointestinal malignancies.
ABSTRACT
BACKGROUND: Erectile dysfunction (ED) in men is increasingly becoming a major problem worldwide. The damaging effects on the psyche and the anxiety regarding sexual performance and overall life satisfaction could be irreversible. AIMS: The objective of this study was to compare domains of quality of life (QOL) in men with ED in the Niger Delta region of Nigeria in order to determine the contextual social variables. METHOD: In a cross-sectional study, 400 male patients attending the general outpatient clinic between January and March 2009 were randomly assessed for ED and QOL, using abridged version of the International Index of Erectile function and the World Health Organization Quality of life instrument. RESULTS: A total of 166 (41.7%) subjects suffered from ED, 80 (48.2%) from medical illness, 56 (33.7%) from surgical problems and 30 (18.1%) from undiagnosed problems. Social relationships and psychological health indices of QOL were severely impaired in men with ED than the general, overall, physical and environmental health. CONCLUSION: An inference from this study suggests that sexual function promotes psychological well-being as well as interpersonal relationships. Therefore, monitoring these indices of QOL in men with ED is important to boost their confidence and self-esteem needed for a better QOL.
