ABSTRACT
The passage of time that evoke aging; the tilted redox balance that contribute oxidative entropy; the polarization of microglia cells that produce inflammatory phenotype; all represent the intricacies of CNS-dependent disease progression. Neurological diseases that result from CNS injury raise social concerns and the available therapeutic strategies are frustrated by low efficacy, high toxicity, and multiple side effects. However, emergent studies have shown the neuroprotective role of natural compounds - including chalcones - with high efficacy in the protection of CNS structures. These compounds reportedly demonstrate neurotrophic mechanism through the upregulation of neurotrophic factors, anti-apoptotic Bcl-2, and downregulation of Bax protein; anti-neuroinflammatory mechanism via the inhibition of neuroinflammatory pathways, attenuated secretion of pro-inflammatory cytokines, prevention of blood brain barrier (BBB) disruption, and protection against nerve senescence; antioxidant mechanism through the upregulation of Nrf2 activities, inhibition of Keap1, synthesis of antioxidant enzymes, and maintenance of high antioxidant/oxidant ratio. All these mechanisms represent chalcones' neuroprotective mechanisms. In this review, we highlight different pathways involved in CNS-related diseases and elucidate various mechanisms by which chalcones can perturb these shunts as a potential therapeutic modality.
Subject(s)
Central Nervous System Diseases/drug therapy , Central Nervous System/drug effects , Chalcones/therapeutic use , Inflammation Mediators/metabolism , Neurogenesis/drug effects , Neurons/drug effects , Neuroprotective Agents/therapeutic use , Oxidative Stress/drug effects , Animals , Anti-Inflammatory Agents/pharmacology , Antioxidants/pharmacology , Central Nervous System/metabolism , Central Nervous System/pathology , Central Nervous System/physiopathology , Central Nervous System Diseases/metabolism , Central Nervous System Diseases/pathology , Central Nervous System Diseases/physiopathology , Humans , Neurons/metabolism , Neurons/pathology , Oxidation-Reduction , Signal TransductionABSTRACT
With social distancing being a key preventative measure of COVID-19, proper provision of healthcare services becomes a challenge as healthcare professionals are concerned about the risk of potential infection. Telemedicine, a practice that uses telecommunication networks for the delivery of healthcare services and medical education, has been adopted by several countries and has shown to provide positive outcomes. This concept is poorly practiced in African Countries compared to other countries of the world. This paper reiterates the need for the expansion of telemedical systems in Africa for the dual goals of COVID-19 prevention and provision of quality healthcare services to people.
