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[Hypotensive effect of oxatriazolium-5-olate derivative].
Artem'eva, M M; Postnikov, A B; Akinfrieva, O V; Daliger, I L; Shevelev, S A; Medvedev, O S; Medvedeva, N A.
Eksp Klin Farmakol ; 71(5): 25-7, 2008.
Article in Russian | MEDLINE | ID: mdl-19093367

ABSTRACT

Intravenous administration of azasidnon-6 (oxatriazolium-5-olate derivative) induces prolonged dose-dependent decrease in arterial blood pressure in awake Wistar and SHR rats. Hypotensive effects of azasidnon-6 in SHR rats is significantly higher during inhibition of endogenous NO synthesis.


Subject(s)
Antihypertensive Agents/pharmacology , Blood Pressure/drug effects , Hypertension/drug therapy , Hypertension/physiopathology , Triazoles/pharmacology , Animals , Delayed-Action Preparations/pharmacology , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Hypertension/metabolism , Male , Nitric Oxide/metabolism , Rats , Rats, Inbred SHR , Rats, Wistar
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