The feasibility and validity of a wearable sensor system to assess the stability of high-functioning lower-limb prosthesis users.

INTRODUCTION: Lower-limb prosthesis users (LLPUs) experience increased fall risk due to gait and balance impairments. Clinical outcome measures are useful for measuring balance impairment and fall risk screening but suffer from limited resolution and ceiling effects. Recent advances in wearable sensors that can measure different components of gait stability may address these limitations. This study assessed feasibility and construct validity of a wearable sensor system (APDM Mobility Lab) to measure postural control and gait stability. MATERIALS AND METHODS: Lower-limb prosthesis users (n=22) and able-bodied controls (n=24) completed an Instrumented Stand-and-Walk Test (ISAW) while wearing the wearable sensors. Known-groups analysis (prosthesis versus controls) and convergence analysis (Prosthetic Limb Users Survey of Mobility [PLUS-M] and Activity-specific Balance Confidence [ABC] Scale) were performed on 20 stability-related measures. RESULTS: The system was applied without complications; however missing anticipatory postural adjustment data points for nine subjects affected the analysis. Of the 20 analyzed measures output by the sensors, only three significantly differed (p≤.05) between cohorts, and two demonstrated statistically significant correlations with the self-report measures. CONCLUSIONS: The results of this study suggest the clinical feasibility but only partial construct validity of the wearable sensor system in conjunction with the ISAW test to measure LLPU stability and balance. The sample consisted of high-functioning LLPUs, so further research should evaluate a more representative sample with additional outcome measures and tasks.

An MRI investigation of the effects of user anatomy and wheelchair cushion type on tissue deformation.

AIM OF THE STUDY: Tissue deformation is recognized as an important risk factor for pressure injuries. This study investigated the effects of anatomy and wheelchair cushion type on tissue deformation. MATERIALS AND METHODS: Direct 3-dimensional tissue deformation response was measured for six participants sitting on six different wheelchair cushions using MR imaging. Two participants had a traumatic spinal cord injury (SCI) within one year of the assessment, two sustained traumatic SCI at least 13 years prior, and two were without SCI. Tissue deformation was quantified using the difference in volume of tissue beneath the ischial tuberosity (IT) between unloaded and loaded (sitting) conditions. RESULTS: The participants with SCI tended to have less muscle tissue volume beneath their ITs while sitting compared to participants without SCI. Reductions in muscle and fat volumes in the loaded conditions varied depending on both cushion and participant. Higher interface pressures tended to be associated with lower unloaded tissue thicknesses. CONCLUSION: The study showed no single cushion type tested produced the lowest amount of tissue deformation across all participants. Individual anatomy and cushion type affect deformation response of tissue and related pressure injury risk.

Dermal absorption for pesticide health risk assessment: Harmonization of study design and data reporting for North American Regulatory submissions.

Although an internationally-adopted in vitro dermal absorption test guideline is available (OECD Test Guideline 428), the replacement of the in vivo approach in North America for pesticide formulations has not occurred due to concern over the reliability and consistency of the in vitro results. A 2012 workshop convened a panel of experts in the conduct of in vitro studies used for pesticide risk assessment, together with North American regulators, to examine techniques for in vitro dermal absorption testing. Discussions led to the recommended "best practices" for the conduct of in vitro dermal absorption studies provided herein. The workshop participants also developed recommendations for reporting study results in order to improve the quality and consistency of the data submitted to regulatory agencies in North America. Finally, a case study is presented that illustrates the use of the "triple-pack" approach; the studies, conducted for the registration of sulfoxaflor, follow the standardized recommendations provided at the workshop. In addressing the concerns of these regulators and of the regulated community, and providing harmonized recommendations to facilitate comparative data analyses, it is anticipated that wider acceptance of in vitro dermal absorption studies alone can be achieved for pesticide risk assessment.

Kinesiology taping does not alter shoulder strength, shoulder proprioception, or scapular kinematics in healthy, physically active subjects and subjects with Subacromial Impingement Syndrome.

OBJECTIVE: To examine the effect of kinesiology tape (KT) on shoulder strength, proprioception, and scapular kinematics in healthy and Subacromial Impingement Syndrome (SAIS) subjects. DESIGN: Placebo-controlled quasi-experimental study. SETTING: Research laboratory. PARTICIPANTS: A total of 30 physically active subjects participated. Ten healthy subjects with no previous history of shoulder pathology received KT on the dominant shoulder. Twenty subjects with shoulder pain for a minimum of two weeks and presenting with clinical signs of impingement were allotted to receive KT (n = 10) or placebo taping (PT, n = 10) on the involved shoulder. MAIN OUTCOME MEASURES: All participants were tested pre- and post-application. Shoulder internal/external rotation (IR/ER) strength was assessed with isokinetic dynamometry (average peak torque/body weight). Shoulder IR/ER proprioception was assessed through threshold to detect passive motion (mean absolute error in degrees). Scapular position at 90° and 120° of shoulder abduction during arm raising/lowering were assessed using a 3D motion analysis system. RESULTS: No significant within group or between group differences were demonstrated for any measure. CONCLUSIONS: Taping does not appear to aid/impair shoulder strength, shoulder proprioception, or scapular kinematics. Future research should explore if the effects of KT are time-dependent and similar in other pathologies.

Feasibility of freehand ultrasound to measure anatomical features associated with deep tissue injury risk.

Deep tissue injuries (DTI) are severe forms of pressure ulcers that start internally and are difficult to diagnose. Magnetic resonance imaging (MRI) is the currently preferred imaging modality to measure anatomical features associated with DTI, but is not a clinically feasible risk assessment tool. B-mode ultrasound (US) is proposed as a practical, alternative technology suitable for bedside or outpatient clinic use. The goal of this research was to confirm US as an imaging modality for acquiring measurements of anatomical features associated with DTI. Tissue thickness measurements using US were reliable (ICC=.948) and highly correlated with MRI measurements (muscle r=.988, p ≤ .001; adipose r=.894, p ≤ .001; total r=.919; p ≤ .001). US measures of muscle tissue thickness were 5.4mm (34.1%) higher than MRI, adipose tissue thickness measures were 1.6mm (11.9%) lower, and total tissue thickness measures were 3.8mm (12.8%) higher. Given the reliability and ability to identify high-risk anatomies, as well as the cost effectiveness and availability, US measurements show promise for use in future development of a patient-specific, bedside, biomechanical risk assessment tool to guide clinicians in appropriate interventions to prevent DTI.

Reliability and measurement precision of concentric-to-isometric and eccentric-to-isometric knee active joint position sense tests in uninjured physically active adults.

OBJECTIVES: Proprioception is important because it is used by the central nervous system to mediate muscle control of joint stability, posture, and movement. Knee active joint position sense (AJPS) is one representation of knee proprioception. The purpose of this study was to establish the intra-tester, inter-session, test-retest reliability of concentric-to-isometric (seated knee extension; prone knee flexion) and eccentric-to-isometric (seated knee flexion; prone knee extension) knee AJPS tests in uninjured adults. DESIGN: Descriptive. SETTING: University laboratory. PARTICIPANTS: Six males, six females (age 26.2 ± 5.7 years; height 171.1 ± 9.6 cm; mass 71.1 ± 16.6 kg). MAIN OUTCOME MEASURES: Mean absolute error (AE; °); intraclass correlation coefficient (ICC) (2,1); standard error of measurement (SEM; °). RESULTS: Mean AE ranged from 3.18° to 5.97° across tests. The ICCs and SEMs were: seated knee extension 0.13, 1.3°; prone knee flexion 0.51, 1.2°; seated knee flexion 0.31, 1.7°; prone knee extension 0.87, 1.4°. CONCLUSIONS: The prone knee flexion and prone knee extension tests demonstrated moderate to good reliability. Prone knee flexion and prone knee extension AJPS tests may be useful in cross-sectional studies estimating how proprioception contributes to knee functional joint stability or prospective studies estimating the role of proprioception in the onset of knee injury.

Reliability and validity of instrumented soccer equipment.

Ankle ligament sprains are the most common injury in soccer. The high rate of these injuries demonstrates a need for novel data collection methodologies. Therefore, soccer shoes and shin guards were instrumented with inertial sensors to measure ankle joint kinematics in the field. The purpose of this study was to assess test-retest reliability and concurrent criterion validity of a kinematic assessment using the instrumented soccer equipment. Twelve soccer athletes performed athletic maneuvers in the laboratory and field during 2 sessions. In the laboratory, ankle joint kinematics were simultaneously measured with the instrumented equipment and a conventional motion analysis system. Reliability was assessed using ICC and validity was assessed using correlation coefficients and RMSE. While our design criteria of good test-retest reliability was not supported (ICC > .80), sagittal plane ICCs were mostly fair to good and similar to motion analysis results; and sagittal plane data were valid (r = .90-98; RMSE < 5°). Frontal and transverse plane data were not valid (r < .562; RMSE > 3°). Our results indicate that the instrumented soccer equipment can be used to measure sagittal plane ankle joint kinematics. Biomechanical studies support the utility of sagittal plane measures for lower extremity injury prevention.

Reliability and validity of an accelerometry based measure of static and dynamic postural stability in healthy and active individuals.

Postural stability is an important measure in both research and clinical practice. A portable, easy to use device that can provide higher resolution than current clinical tests may allow for better identification of patients or athletes with postural stability deficits. The purpose of this study was to evaluate the ability of a tri-axial accelerometer to quantify postural stability in a healthy athletic population. Ten subjects were recruited to determine the reliability of the accelerometer to measure dynamic postural stability and thirteen were recruited to compare the accelerometer measures across tasks of varying difficulty. Subjects were asked to complete four static postural stability tasks with eyes open and eyes closed and two dynamic postural stability tasks for a total of ten tasks. During each task postural stability was measured using a tri-axial accelerometer and force platform. Differences between postural stability scores between tasks and the correlation between the two measures were assessed. The accelerometer demonstrated moderate to good test-retest reliability (ICC=0.732 to 0.899). Only the medial-lateral axis of the accelerometer showed significant differences between static tasks but all directions were able to show significant differences between static and dynamic tasks. Additionally, Spearman's ranked correlations showed little to no correlation between the accelerometer and force platform scores. Accelerometers are a reliability tool for postural stability that measure low difficulty tasks best in the medial-lateral direction. Low correlation between the accelerometer and force platform suggest that these two methods are not measuring the same components of postural stability.

Relationship between tibial acceleration and proximal anterior tibia shear force across increasing jump distance.

Proximal anterior tibia shear force is a direct loading mechanism of the anterior cruciate ligament (ACL) and is a contributor to ACL strain during injury. Measurement of this force during competition may provide insight into risk factors for ACL injury. Accelerometers may be capable of measuring tibial acceleration during competition. The purpose of this study was to examine the relationship between acceleration measured by a tibia-mounted accelerometer and proximal anterior tibia shear force as measured through inverse dynamics and peak posterior ground reaction forces during two leg stop-jump tasks. Nineteen healthy male subjects performed stop-jump tasks across increasing jump distances. Correlation coefficients were calculated to determine if a relationship exists between accelerometer data and proximal anterior tibia shear force and peak posterior ground reaction force. An analysis of variance was performed to compare these variables across jump distance. Significant correlations were observed between accelerometer data and peak posterior ground reaction force, but none between accelerometer data and proximal anterior tibia shear force. All variables except peak proximal anterior tibia shear force increased significantly as jump distance increased. Overall, results of this study provide initial, positive support for the use of accelerometers as a useful tool for future injury prevention research.

Local anaesthetics use does not suppress muscle activity following an ankle injection.

PURPOSE: To determine if peroneus longus (PL), peroneus brevis (PB), medial gastrocnemius (MG) and tibialis anterior (TA) muscle activation patterns during inversion perturbation and running tasks are suppressed following lidocaine injection to the anterior talofibular (ATF) and calcaneofibular (CF) ligament regions. METHODS: Fourteen recreationally active male subjects (age, 24.8 ± 2.9 years; height, 177.0 ± 6.0 cm; mass, 77.7 ± 6.7 kg) participated. Testing was performed under five injection conditions to the ATF and CF regions: 1 ml saline, 1 ml lidocaine, 3 ml saline, 3 ml lidocaine or no injection. Following injection condition, traditional ankle taping was applied. Electromyography patterns of the PL, PB, MG and TA were collected while subjects performed continuous lateral jumps on a custom-built device which elicited an ankle inversion perturbation and treadmill running (3.35 m s(-1), 0.5 % incline). RESULTS: No significant differences were demonstrated in muscle activation patterns of the PL (n.s.), PB (n.s.), MG (n.s.) or TA (n.s.) for any variable across injected conditions during both tasks. Statistical power was 0.214-0.526 for the PL, 0.087-0.638 for the PB, 0.115-0.560 for the MG and 0.118-0.410 for the TA. CONCLUSIONS: Injection of lidocaine up to 3 ml to the ATF and CF regions did not suppress muscle activity of the PL, PB, MG or TA during the inversion perturbation or running tasks. Injection up to 3 ml of 1 % lidocaine to the ATF and CF regions may be used without sacrificing the muscle activation patterns about the ankle. This finding is clinically relevant since the use of the injection does not put the patient at any higher risk of reinjury to the site.

Test-retest reliability and descriptive statistics of geometric measurements based on plantar pressure measurements in a healthy population during gait.

Previous studies have demonstrated that pressure, force, area, and time measurements can be reliably collected from pedobaragraphic platforms, but no studies have analyzed geometric measurements. The purpose of this study was to establish the test-retest reliability of geometric measurements obtained during gait at a self-selected speed using a two-step approach. Data were collected on both feet for 10 healthy participants using the emed-x platform. Reliability of 15 geometric measurements was assessed using intraclass correlation coefficients (ICC). All 15 measurements were demonstrated to be reliable (ICC>0.8), with 12 measurements ICC>0.90. Collection of geometric measurements at a self-selected pace with the emed-x platform was found to be reliable and can be used for investigation in research settings.

Interface shear and pressure characteristics of wheelchair seat cushions.

Pressure ulcer incidence rates have remained constant despite advances in support surface technology. Interface shear stress is recognized as a risk factor for pressure ulcer development and is the focus of many shear reduction technologies incorporated into wheelchair cushions; however, shear reduction has not been quantified in the literature. We evaluated 21 commercial wheelchair seat cushions using a new methodology developed to quantify interface shear stress, interface pressure, and horizontal stiffness. Interface shear stress increased significantly with applied horizontal indenter displacement, while no significant difference was found for interface pressure. Material of construction resulted in significant differences in interface shear stress, interface pressure, and horizontal stiffness. This study shows that the existing International Organization for Standardization (ISO) 16840-2 horizontal stiffness measure provides similar information to the new horizontal stiffness measure. The lack of a relationship between interface shear stress and the overall horizontal stiffness measure, however, suggests that a pressure and shear force sensor should be used with the ISO 16840-2 horizontal stiffness measure to fully quantify a cushion's ability to reduce interface shear stress at the patient's bony prominences.