ABSTRACT
In response to recent pertussis resurgence, a multi-agency recommendation that students receive a one-time Tdap vaccine was introduced. Post mandate there was sequential increase in the Tdap vaccine uptake in the targeted population.
Subject(s)
Diphtheria-Tetanus Vaccine/administration & dosage , Students/statistics & numerical data , Vaccination/statistics & numerical data , Whooping Cough/prevention & control , Humans , IllinoisABSTRACT
Intrathecal methotrexate (IT MTX) and high-dose intravenous methotrexate (HD MTX) are important components of treatment in high-risk acute leukemia. We describe five Hispanic adolescents with high-risk acute leukemia at our institution who experienced MTX-induced neurotoxicity. All patients were eventually rechallenged with MTX. Two of the five patients had a second episode of neurotoxicity, but all patients recovered. Further studies should be performed to determine whether Hispanic patients are more susceptible to MTX neurotoxicity.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Leukemia/drug therapy , Leukemia/epidemiology , Methotrexate/adverse effects , Neurotoxicity Syndromes/epidemiology , Acute Disease , Adolescent , Age of Onset , Cohort Studies , Female , Hispanic or Latino , Humans , Injections, Intravenous , Injections, Spinal , Male , Methotrexate/administration & dosage , Risk Factors , Young AdultABSTRACT
Pertussis incidence has increased in recent years; we obtained incidence data from 1990-2014 from the Illinois Department of Public Health Web site. We analyzed the crude incidence rates using Joinpoint regression software. Four joinpoints were observed (2001, 2004, 2007, and 2012). Disease modeling can be used for disease control and planning by extrapolating the trend in the incidence data and applying to annual population estimates.
