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1.
J Org Chem ; 66(4): 1512-3, 2001 Feb 23.
Article in English | MEDLINE | ID: mdl-11312992
2.
Org Lett ; 2(12): 1725-7, 2000 Jun 15.
Article in English | MEDLINE | ID: mdl-10880211

ABSTRACT

[reaction: see text] A DNA-binding dye, 4',6-diamidino-2-phenylindole (DAPI) signals AT base pairing with a shift in the fluorescence emission spectrum. The signaling follows W-C base-pairing rules, and both dAMP and dTMP are required for the largest spectral shift. Thus, the dye with its two phosphate receptor sites functions as a molecular NAND gate accepting nucleotides as inputs. Moreover, when the observation wavelength is changed from 470 to 411.5 nm, the gate functions in TRANSFER logic.


Subject(s)
Base Pairing/drug effects , Energy Transfer/drug effects , Adenosine Monophosphate/chemistry , Adenosine Monophosphate/metabolism , Fluorescent Dyes/pharmacology , Indoles/pharmacology , Information Science , Information Theory , Intercalating Agents/pharmacology , Thymidine Monophosphate/chemistry , Thymidine Monophosphate/metabolism
3.
Talanta ; 51(4): 693-9, 2000 Apr 03.
Article in English | MEDLINE | ID: mdl-18967901

ABSTRACT

A reservoir type of optode is described for simultaneous and remote determination of Cd and Zn using [9-(1',4',7',10',13'-pentaazacyclopentadecyl)methylanthracene] as the fluorophore. Simultaneous analysis was achieved by the significant perturbation in the fluorescence spectrum of the Cd-ligand complex while the Zn complex only results in enhancement in the fluorescence intensity as compared to ligand alone. The ion permeability of several membranes were examined; Nafion and cellophane were used for the construction of the optode. Using the optode constructed with cellophane, for 20 min immersion time, the 3-s detection limits were found to be 4.5 mug l(-1) for Cd and 0.6 mug l(-1) for Zn.

4.
Anal Biochem ; 213(2): 285-9, 1993 Sep.
Article in English | MEDLINE | ID: mdl-8238903

ABSTRACT

We describe the chemical synthesis and fluorescence spectral characterization of a styryl-benzothiazole probe which contains the Ca2+ chelating group BAPTA as an integral part of the chromophoric system. The visible absorption spectrum of this probe displays a dramatic shift in the long wavelength maxima from 508 to 407 nm upon complexation with Ca2+, with a Ca2+ dissociation constant of 1.5 microM. The emission maximum centered at 615 nm is well shifted from the absorption. The emission spectrum displays a small blue shift upon binding Ca2+, allowing this probe to possibly be used as an emission wavelength-ratiometric probe using a single-excitation wavelength. This probe is likely to be the first of a series of long-wavelength ratiometric Ca2+ probes whose structure can be modified for improved quantum yield or altered Ca2+ affinity.


Subject(s)
Calcium/analysis , Fluorescent Dyes , Styrenes , Thiazoles , Chemical Phenomena , Chemistry, Physical , Egtazic Acid/analogs & derivatives , Egtazic Acid/chemical synthesis , Fluorescent Dyes/chemical synthesis , Quantum Theory , Spectrometry, Fluorescence/methods , Styrenes/chemical synthesis , Thiazoles/chemical synthesis
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