ABSTRACT
This prospective, randomized clinical trial compared the treatment of ganglia by either hyaluronidase injection and aspiration or surgical excision. Fifty patients were randomly allocated to each group and 46 patients in the hyaluronidase group and 43 in the surgical group were available for follow-up at 1 year. Patients with ganglia treated with hyaluronidase had a recurrence rate of 77%, which was significantly higher (P<0.01) than the recurrence rate after surgery (24%).
Subject(s)
Hand , Hyaluronoglucosaminidase/administration & dosage , Synovial Cyst/therapy , Wrist Joint/surgery , Adult , Humans , Injections, Intralesional , Male , Prospective Studies , Suction , Synovial Cyst/surgery , Treatment OutcomeSubject(s)
Atrial Fibrillation/etiology , Atrial Fibrillation/mortality , Myocardial Ischemia/complications , Atrial Fibrillation/drug therapy , Double-Blind Method , Eptifibatide , Female , Humans , Male , Myocardial Ischemia/drug therapy , Peptides/therapeutic use , Platelet Aggregation Inhibitors/therapeutic use , Proportional Hazards Models , Stroke/etiology , Stroke/mortality , Survival Analysis , Treatment OutcomeABSTRACT
BACKGROUND: A proportion of patients who present with suspected acute coronary syndrome (ACS) are found to have insignificant coronary artery disease (CAD) during coronary angiography, but these patients have not been well characterized. METHODS AND RESULTS: Of the 5767 patients with non-ST-segment elevation ACS who were enrolled in the Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin (Eptifibatide) Therapy (PURSUIT) trial and who underwent in-hospital angiography, 88% had significant CAD (any stenosis >50%), 6% had mild CAD (any stenosis >0% to
Subject(s)
Coronary Disease/diagnosis , Coronary Disease/therapy , Acute Disease , Aged , Coronary Angiography , Coronary Disease/physiopathology , Diagnosis, Differential , Eptifibatide , Female , Humans , Infusions, Intravenous , Male , Middle Aged , Peptides/administration & dosage , Peptides/pharmacokinetics , Peptides/therapeutic use , Placebos , Platelet Aggregation Inhibitors/administration & dosage , Platelet Aggregation Inhibitors/pharmacokinetics , Platelet Aggregation Inhibitors/therapeutic use , Predictive Value of Tests , Random Allocation , Reproducibility of Results , Severity of Illness Index , Therapeutic Equivalency , Time Factors , Treatment OutcomeABSTRACT
Two butchers, men aged 25 and 48 years, sustained a perforating heart injury when they made a vertical cut. They were rushed to hospital. The first patient was haemodynamically stable on arrival. The second had hypotension and cardiac ultrasonography revealed increased fluid in the pericardium; he was subjected to pericardiocentesis. The heart wounds in both patients were sutured via a left-sided anterolateral thoracotomy; the younger had a wound in the left ventricle, the older both a dorsal and a ventral transmural perforation of the right ventricle. Both patients could be discharged after a little over a week in good condition. Employers in abbattoirs should provide protective clothing fastening high enough to prevent heart wounds.
