ABSTRACT
The expression of insulin-like growth factor 2 (IGF2) and insulin-like growth factor binding protein 2 (IGFBP2) in 11 cases of hepatoblastoma was studied by means of in situ mRNA hybridization using digoxigenin (DIG)-labeled riboprobes. The results showed that both IGF2 and IGFBP2 transcripts are present in hepatoblastoma and that their expression is inversely correlated with the degree of tumor cell differentiation. The data suggested that IGF2 and IGFBP2 gene expression could be regarded as a marker for assessment of the degree of differentiation in hepatoblastoma.
Subject(s)
Carrier Proteins/genetics , Hepatoblastoma/genetics , Insulin-Like Growth Factor II/genetics , Liver Neoplasms/genetics , Child, Preschool , Female , Gene Expression , Humans , In Situ Hybridization , Infant , Insulin-Like Growth Factor Binding Protein 2 , Liver/metabolism , Male , RNA, Messenger/biosynthesisABSTRACT
The case of a minor salivary gland tumour, arising from the tongue, with nodal metastasis is presented. Biopsy of the tumour and fine-needle aspiration cytology of the neck swelling showed the presence of a clear cell carcinoma with evidence of nodal metastases. A commando operation was performed and the defect was reconstructed using a local tongue flap. The literature review indicated that the neoplasm was rare and its site of occurrence rather unusual.
Subject(s)
Adenocarcinoma, Clear Cell/metabolism , Glycogen/metabolism , Tongue Neoplasms/metabolism , Adenocarcinoma, Clear Cell/pathology , Adult , Female , Humans , Lymphatic Metastasis , Neck , Salivary Glands, Minor/pathology , Tongue Neoplasms/pathologyABSTRACT
An 18-year-old Malay lady was treated with high dose steroids for three and a half years for idiopathic thrombocytopaenic purpura. At 21 years, after a series of relapses, a splenectomy was carried out. In addition, two nodules at the hilum of the spleen were also removed. Histological examination of these nodules revealed features of Kaposi's sarcoma. Kaposi's sarcoma resulting from immunosuppression by corticosteroids is rare. Our patient is the first such case reported in Malaysia.
Subject(s)
Adrenal Cortex Hormones/adverse effects , Sarcoma, Kaposi/etiology , Adolescent , Female , Humans , Purpura, Thrombocytopenic/drug therapyABSTRACT
The term tumefactive fibroinflammatory lesion is used to describe an unusual fibrosclerosing disorder that behaves in a malignant way clinically but is histologically benign. Lesions in the head and neck are believed to be part of the broader fibrosclerosing syndrome which include pseudotumour of the orbit, Reidel's thyroiditis, sclerosing cholangitis and mediastinal fibrosis. Clinical diagnosis is often difficult and relies heavily on histopathology. Steroid therapy is suggested as the first line of management, while surgery or radiation therapy is reserved for failures.
