Correlation Between Serum Prostate-Specific Antigen and Testosterone Following Bilateral Total Orchidectomy for Patients with Advanced Prostate Cancer in Jos, Nigeria.

Background: Prostate cancer is a common malignancy affecting men beyond the middle age. Monitoring of treatment of the disease using serum testosterone and prostate-specific antigen (PSA) offers an index of treatment efficacy and a reflection of disease progression, respectively. The objective of this study was to determine the relationship between changing values of serum PSA and serum testosterone in patients with advanced prostate cancer following bilateral total orchidectomy (BTO). Materials and Methods: This was a prospective longitudinal study carried out over a 1-year period among patients who met the inclusion criteria. Each patient underwent detailed clinical evaluation including history, as well as physical examination with digital rectal examination of the prostate. Also, samples of serum PSA and testosterone were obtained and sent to the same chemical pathology laboratory before intervention with BTO, then at 2, 4, and 6 months. The values of serum PSA and testosterone were obtained and changes over this period were compared for both parameters. The analyses included independent inferential analysis of serum testosterone and serum PSA over a period of 6 months and a correlation of the two parameters over the same period. Results were analysed using SPSS version 23. P value of <0.05 was regarded significant. Charts and tables were used for data expression. Kruskal-Wallis and Wilcoxon tests were used for individual inferential analysis of serum testosterone and PSA. The Spearman ranked correlation coefficient test was used to determine the degree of correlation of serum testosterone and serum PSA levels while Pearson correlation coefficient test was used to determine the degree of correlation between the percentage changes in serum testosterone and PSA measured over the period of the study. Results: A total of forty-two men with mean age of 68.49 ± 8.86 years who had advanced prostate cancer were recruited. The histologic type of prostate cancer diagnosed for all the patients was adenocarcinoma. The mean Gleason score was 7.98 ± 1.09, while the modal Gleason grade group represented was grade group 5. There were statistically significant changes in serum testosterone and PSA levels in response to bilateral total orchidectomy with P value of <0.001. However, there was no statistically significant correlation between serum testosterone and serum PSA levels following bilateral total orchidectomy with p values of 0.492, 0.358, 0.134, and 0.842 at baseline, 2, 4, and 6 months, respectively. There was a significant correlation between the percentage changes in serum testosterone and PSA measured between baseline and 2 months with P value of <0.001. However, there was no statistically significant correlation between the percentage changes in serum testosterone and PSA measured between baseline measured against 4 months and 6 months with P value of 0.998 and 0.638, respectively. Conclusion: The study showed that reduction in serum levels of testosterone and PSA following BTO was significant. It also revealed no statistically significant correlation between serum testosterone and serum PSA measured over 6 months following bilateral total orchidectomy.

The predictive value of intravesical prostatic protrusion on the outcome of trial without catheter in patients with acute urinary retention from benign prostatic hyperplasia at Jos University Teaching Hospital, Nigeria: a prospective observational study.

Introduction: acute urinary retention represents a significant and painful event in the natural history of benign prostatic hyperplasia. This study was to determine the value of intravesical prostatic protrusion in predicting the outcome of trial without catheter in patients presenting with acute urinary retention from benign prostatic hyperplasia. Methods: this was a prospective observational study carried out over a one-year period among 78 patients with acute urinary retention from benign prostatic hyperplasia who presented at the Accident and Emergency Department of Jos University Teaching Hospital. They were clinically evaluated, and a urethral catheter was passed to relieve the retention. Trans-abdominal ultrasound assessment of intravesical prostatic protrusion, was performed after relief of acute urinary retention. Patients were placed on tamsulosin tablets 0.4mg daily for three days and they had a trial without catheter on the third day. A receiver operating characteristic curve was used to determine the predictive power of intravesical prostatic protrusion on the outcome of trial without catheter in patients with acute urinary retention from benign prostatic hyperplasia. A p value of <0.05 was considered as significant. Results: seventy-eight patients were enrolled in the study. The mean age and was 65.00 (SD 7.28) years. The mean intravesical prostatic protrusion, voided volume and maximum flow rate were 13.04 (SD 10.94) mm, 89.46 (SD 6.14) mls and 7.63 (SD 5.69) ml/s respectively. Intravesical prostatic protrusion (area under the curve= 0.843, p=0.001) predicted the outcome of trial without catheter with a cut off mark of <7.4, using the receiver operating characteristic curve. Conclusion: intravesical prostatic protrusion significantly predicted the outcome of trial without catheter in patients with benign prostatic hyperplasia presenting with acute urinary retention. It is a useful tool in the initial evaluation of patients with benign prostatic hyperplasia presenting with acute urinary retention.

Dorsal onlay buccal mucosa graft urethroplasty for bulbar urethral stricture: a single centre experience.

INTRODUCTION: the successful treatment for urethral strictures demands not just attention to surgical details but careful selection of the reconstructive technique. For long segment urethral strictures substitution urethroplasty is required. This study sought to determine the success rate and complications of dorsal onlay buccal mucosal graft (BMG) urethroplasty for long segment urethral strictures in our hospital. METHODS: this was a retrospective study carried out at Jos University Teaching Hospital from March 2015 to March 2018. The case notes of male patients who had dorsal onlay buccal mucosal graft urethroplasty for long segment bulbar urethral stricture within the study period were retrieved. Patients´ demographics, cause and nature of urethral strictures, duration of follow up, the success rate and complications were collected and subjected to statistical analysis using SPSS® version 22. RESULTS: twenty-four men with mean age of 45 years (range 14-67 years) had dorsal onlay buccal mucosal graft urethroplasty during the study period. The mean stricture length was 4.5cm (range, 2-7cm). After a mean follow up duration of 2 years (range, 1 4 years), 21(87.5%) patients had a successful urethroplasty as they were able to pass urine at one year post urethroplasty without lower urinary tract symptoms, while 3(12.5%) had recurrence of the urethral stricture. At the recipient site, 2(8.3%) patients had primary bleeding that did not require blood transfusion. Also, 2(8.3%) patients had superficial wound infection which was treated with antibiotics. At the donor site, 4(16.7%), 2(8.3%), 4(16.7%) had donor site swelling, transient bleeding and soreness respectively. CONCLUSION: dorsal onlay BMG urethroplasty has a good success rate and minor complications and therefore suitable for long segment bulbar urethral strictures.

Retrograde ureteroscopy in the management of distal ureteric stones: A retrospective analysis of outcome and complications.

Background: Urinary stones affect 8%-15% of the world population. In Nigeria, contemporary reports have shown that the incidence of urinary stones is rising. The distal ureter has been described as the most common location of ureteric stones. This study seeks to review our experience in the ureteroscopic management of distal ureteric stones with a view to appraising the stone clearance rate and the complications seen in our patients. Patients and Methods: This descriptive study reviewed the record of 21 patients, who had semirigid ureteroscopy and pneumatic lithotripsy for distal ureteric stone between October 2015 and September 2018. All patients had computed tomography urography preoperatively to locate the stone. Data on patients' demographics, indication for the surgery, location and size of stone, preoperative double-J (DJ) placement, postoperative DJ stent placement, intraoperative and postoperative complications, and status of stone clearance were retrieved and subjected to statistical analysis. Results: The mean age of the patients was 37.95 ± 11.09 (range, 21-67) years. The mean stone size was 8.06 ± 2.87 mm with a range of 4.8 mm-15.0 mm. Out of the 21 patients, 20 (95.2%) had the procedure for recurrent ureteric colic and 1 (48%) was for hematuria. Four (19.0%) patients had DJ stent preoperatively, whereas 17 (81.0%) patients did not have. Fourteen (66.7%) patients had intraoperative ureteric dilatation. Postoperative DJ stent was placed in 17 (81.0%) patients, whereas 4 (19.0%) patients did not have. Three (14.3%) patients had mucosal flap, 6 (14.3%) had mucosal abrasion, 2 (9.5%) had bleeding, 1 (4.8%) patient had transient hematuria postoperatively, and 2 (9.5%) patients had urinary tract infection. Nineteen (90.5%) patients had complete clearance in a single surgery. Two (9.5%) patients had symptomatic residual fragments that required repeat ureteroscopy. Conclusion: Our study has shown that ureteroscopy is a useful and safe technique in the removal of stones in distal ureter.

RésuméContexte: Les calculs urinaires affectent 8% à 15% de la population mondiale. Au Nigéria, des rapports contemporains ont montré que l'incidence des calculs urinaires augmente. L'uretère distal a été décrit comme l'emplacement le plus courant des calculs urétéraux. Cette étude vise à faire le point sur notre expérience dans la prise en charge urétéroscopique des calculs urétéraux distaux en vue d'évaluer le taux d'élimination des calculs et les complications observées chez nos malades. Les malades et les méthodes: Cette étude descriptive a examiné le dossier de 21 malades, qui avaient une urétéroscopie semi-rigide et une lithotripsie pneumatique pour la pierre urétérale distale entre octobre 2015 et septembre 2018. Tous les malades avaient calculé l'urographie tomographique préopératoire pour localiser la pierre. Les données démographiques des malades, l'indication de la chirurgie, l'emplacement et la taille de la pierre, le placement préopératoire du double J (DJ), le placement du stent DJ postopératoire, les complications peropératoires et postopératoires et l'état de la clairance des calculs ont été récupérés et soumis à une analyse statistique. Résultats: L'âge moyen des malades était de 37,95 ± 11,09 ans (extrêmes: 21­67). La taille moyenne de la pierre était de 8,06 ± 2,87 mm avec une portée de 4,8 mm à 15,0 mm. Sur les 21 malades, 20 (95,2%) ont eu la procédure pour les coliques urétérales récurrentes et 1 (48%) pour l'hématurie. Quatre (19,0%) malades avaient un stent DJ en préopératoire, tandis que 17 (81,0%) malades n'en avaient pas. Quatorze (66,7%) malades avaient une dilatation urétérale peropératoire. Un stent DJ postopératoire a été placé chez 17 (81,0%) malades, alors que 4 (19,0%) malades n'en avaient pas. Trois (14,3%) malades avaient un lambeau muqueux, 6 (14,3%) avaient une abrasion muqueuse, 2 (9,5%) avaient des saignements, 1 (4,8%) avaient une hématurie transitoire postopératoire et 2 (9,5%) avaient une infection des voies urinaires. Dix-neuf (90,5%) malades avaient une clairance complète en une seule chirurgie. Deux (9,5%) malades présentaient des fragments résiduels symptomatiques nécessitant une urétéroscopie répétée. Conclusion: Notre étude a montré que l'urétéroscopie est une technique utile et sûre pour l'élimination des calculs dans l'uretère distal.

Lower urinary tract symptoms in patients with advanced prostate cancer: What are the outcomes of androgen deprivation therapy?

BACKGROUND: Androgen deprivation therapy (ADT) is accepted as the first-line treatment of advanced prostate cancer. This study sets out to determine the outcomes of ADT in reducing lower urinary tract symptoms (LUTS) in patients with advanced prostate cancer and also to determine the quality of life (QoL) of the patients. PATIENTS AND METHODS: This was a prospective study carried out at Jos University Teaching Hospital. All consecutive patients who had LUTS due to advanced prostate cancer were recruited into the study. All patients completed the international prostate symptom score (IPSS) questionnaire, including QoL assessment. Post-void residual (PVR) urine, maximum flow rate (Qmax), prostate specific antigen and total prostate volume (TPV) were assessed. The parameters before and at 12 months were compared. RESULTS: Data from 65 patients were analysed. The mean age of the patients was 68.5 ± 8.67 years with an age range of 46-85 years. Four (6.2%) had mild LUTS before AD, and their symptoms remained mild at 12 months of ADT. Twenty-two (33.9%) patients had moderate urinary symptoms. Of this, 10 (18.5%) patients had symptomatic improvement at 12 months of ADT. Of 39 (60%) patients who presented with severe LUTS, 21 (32.3%) had improvement at 12 months of ADT. Before ADT and at 12 months of ADT, the mean IPSS score, mean TPV, Qmax, PVR and mean QoL score were 23 ± 8.8 and 15 ± 8.8 (P < 0.0001); 79.7 ± 51.4 and 73.4 ± 34.3 (P = 0.212); 8.0 ± 4.7 and 11.2 ± 4.4 (<0.001); 209.8 ± 127.8 and 163 ± 111.4 (<0.001); 4.23 ± 1.2 and 3.24 ± 1.2 (P < 0.001), respectively. Of the 39 patients (60%) with severe urinary symptoms, 18 (27.7%) of patients had urethral catheterization for either acute or chronic urinary retention before ADT. At 12 months on ADT, eight patients (12.3.7%) were still on catheter due to failed attempts at trial without catheter. CONCLUSION: ADT significantly improves urodynamic parameters, IPSS score and IPSS-related QoL. There remains a subset of patients, in whom LUTS persist with negative effects on QoL.

Predictors of urethral stricture recurrence following urethroplasty: a retrospective review at the Jos University Teaching Hospital, Nigeria.

INTRODUCTION: Incidence of urethral stricture recurrence ranges between 2% to 36.4% with 75% occurring within the first 6 months of surgery. Hence, they need to identify the predictors of recurrence following urethroplasty. METHODS: This is a retrospective study involving patients that had urethroplasty from January 2008 to December 2017. Patients' records were reviewed. Analyzed data were for patients with a minimum follow up of one year from the time of urethroplasty and included aetiology of urethral stricture, presence of suprapubic cystostomy, prior urethral dilatation, urine M/C/S, site of urethral stricture, length of urethral stricture, type of urethroplasty, level of training of the surgeon, type of urethral stent used and duration of stenting. Analysis was done using SPSS version 23. P-value of < 0.05 was considered significant. RESULTS: Eighty seven urethroplasties were done, from January 2008 to December 2017. However, only records of 44 patients were accessible. Twenty patients completed duration of follow up ≥ one year. Urethral stricture recurrence was defined as resurgence of Lower Urinary Tract Symptoms (LUTS) within one year. Median age of the patients was 39.5 (± 19) years. Urethral stricture recurrence rate was 25% with mean time to recurrence from urethroplasty of 5.3 (±3) months. The use of preoperative suprapubic catheter (SPC) for urinary diversion as well as urethroplasties performed by the consultants had a lower incidence of recurrence. CONCLUSION: This study found urethral stricture recurrence of 25%. The level of training of surgeon vis-à-vis the expertise and experience seems to be an important factor, though not statistically significant in determining the outcome of urethroplasty.

Multi-center survey of House officers' choice of Medical specialties in Nigeria: preferences and determining factors.

The objective of the study was to determine preferences and factors influencing the choice of medical specialties by House officers. Questionnaires were distributed to House-officers in 4 tertiary hospitals namely: the National hospital, Abuja, the University of Port-Harcourt, the Jos University, and the University of Uyo Teaching Hospitals. The data were simultaneously collected and analyzed using SPSS 20.0 version. Of the 150 questionnaires distributed, 129(86%) were duly filled. The mean age was 22.4 years (range 21-40 years), 79(61.2%) of the respondent were male. Fifty-nine(45.7%) chose training within the country while 32(24.8%) preferred outside as 107(86%) chose training in Teaching Hospitals. Teachers, Resident doctors and parents influenced choices in 34(26.3%), 17(13.1%) and 16(12.4%) respectively. Thirty-four(26.3%), 28 (21.7%), 13(10.1%) and 15(11.6%) preferred obstetrics, surgery, internal medicine and paediatrics respectively. Seventy (46.7%) chose specialties for personal likeness and 17(11.3%) for role models in that specialty. House officers preferred to pursue medical specialty in teaching hospitals within the country and they are motivated by personal fulfillment, independence of practice and role models while more prefer to specialize in more Obstetrics/ Gyaenocology and surgery.