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Gut ; 34(2 Suppl): S102-3, 1993.
Article in English | MEDLINE | ID: mdl-8314469

ABSTRACT

In this study of 17 patients with chronic active hepatitis B, the loss of hepatitis B virus DNA, the return to normal of alanine aminotransferase activities, and histological improvement after six months' treatment with 3 million units three times weekly with interferon alfa-2b, was achieved in 40% of hepatitis B e antigen (HBeAg) positive/anti HBe negative patients, and 41.66% of HBeAg negative/anti HBe positive patients. The reappearance of hepatitis B virus DNA was seen in most patients when treatment was stopped, although a higher percentage of HBeAg positive/anti HBe negative patients (20%) had a sustained loss of hepatitis B virus DNA, return to normal alanine aminotransferase activities, and histological improvement compared with HBeAg negative/anti HBe positive patients (8.3%).


Subject(s)
Hepatitis B/therapy , Hepatitis, Chronic/therapy , Interferon-alpha/therapeutic use , Adult , Aged , Alanine Transaminase/blood , DNA, Viral/blood , Female , Follow-Up Studies , Hepatitis B/enzymology , Hepatitis B virus/genetics , Hepatitis, Chronic/enzymology , Humans , Interferon alpha-2 , Male , Middle Aged , Recombinant Proteins
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