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Bioorg Med Chem Lett
; 16(16): 4266-71, 2006 Aug 15.
Article
in English
| MEDLINE
| ID: mdl-16759855
ABSTRACT
A series of 1,4-dihydroindeno[1,2-c]pyrazoles with a 3-thiophene substituent carrying a urea-type side chain were identified as potent multitargeted (VEGFR and PDGFR families) receptor tyrosine kinase inhibitors. A KDR homology model suggested that the urea moiety is able to interact with a recognition motif in the hydrophobic specificity pocket of the enzyme.