The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia--the risk factor or an indication of a contact with cat?

We assessed IgG antibody to Toxoplasma gondii in 300 inpatients with schizophrenia (SG), 150 outpatients with anxiety and depressive disorders (PCG), and 150 healthy blood donors (HCG). Seropositivity rates were 60.7% for SG, 36.7% for PCG, and 45.3% for HCG (p<0.001). The seropositivity rate for anti-Toxoplasma IgG antibodies in SG was significantly higher that in PCG (chi2 = 23.11, OR = 2.66, p = 0.001) and HCG (chi2 = 9.52, OR = 1.86, p = 0.002). Among SG, 85% of those who reported close cat contact had IgG antibodies to T. gondii. Close cat contacts were reported by 59% of SG, 6% of PCG, and 9% of HCG (p<0.001). There was a nonsignificant positive association between toxoplasmosis and schizophrenia for people with a contact with a cat (OR = 2.221, p = 0.127, CI95 = 0.796-6.192), and significant negative association between toxoplasmosis and schizophrenia for people without contact with a cat (OR = 0.532, p = 0.009, CI95 = 0.332-0.854). Close cat contact (OR = 2.679, p<0.001), 51-65-year age group (OR = 1.703, p<0.001) and education [illiterate+primary (OR = 6.146, p<0.001) and high school (OR = 1.974, p = 0.023)] were detected as independent risk factors in multivariate logistic regression. The effect of toxoplasmosis on risk of schizophrenia disappeared in the complex model analyzed with multivariate logistic regression. In conclusion, our data suggest that the toxoplasmosis has no direct effect on the risk of schizophrenia in Turkey but is just an indication of previous contacts with a cat.

Increased incidence of autoimmune thyroiditis in patients with antipsychotic-induced hyperprolactinemia.

Prolactin (PRL) elevation in patients with prolactin-secreting pituitary tumors has been linked to increased prevalence of thyroid autoantibodies. However, the effects of antipsychotic drug-induced hyperprolactinemia (HPRL) on development of thyroid autoimmunity and also of other autoimmune phenomena have not been previously studied. To examine whether serum PRL levels were associated with the prevalence of thyroid autoantibodies in patients with schizophrenia receiving long-term antipsychotic treatment, we determined serum PRL, thyrotropin, free thyroxine levels, and the presence of antithyroid peroxidase and antithyroglobulin antibodies in 75 consecutive, clinically stable schizophrenic outpatients who had been on stable doses of antipsychotics for at least 3 months, and had no history of overt thyroid disease. We found that the prevalence of hyperprolactinemia was significantly higher in patients positive for thyroid autoantibodies, when compared with patients negative for them (p=0.045). Serum levels of prolactin were also significantly higher in patients with positivity for thyroid autoantibodies (p=0.039). In separate analyses for genders, a trend-level relationship was observed in females between increased levels of prolactin and the presence of thyroid autoantibodies (p=0.060). Our findings suggest that through the associated HPRL, long-term antipsychotic treatment can induce thyroid autoimmunity. Future research is required to investigate, whether other autoimmune processes might be triggered by antipsychotic drug-induced HPRL, and to what extent the immune alterations reported in patients with schizophrenia are related with this phenomenon.

Gender effect on attitudes towards the mentally ill: a survey of Turkish university students.

UNLABELLED: This study investigates gender-associated characteristics of attitudes towards the mentally ill in a large sample of Turkish university students. Factors associated with gender variation were also analyzed. MATERIALS AND METHODS: Student's t-test and linear regression analyses of the results of a vignette-based opinion survey conducted on a sample of final-year Turkish university students (n=700) were performed. The survey consisted of the following: the "Dangerousness Scale:' "Characteristics Scale," "Skill Assessment Scale:" "Social Distance Scale:" "Affective Reaction Scale" and a socio-demographic questionnaire. RESULTS: The results showed a statistically significant difference between female and male respondents with regard to their answers to the questions on the "Dangerousness Scale," "Characteristics Scale" and the "Skill Assessment Scale" In all of these three scales, female respondents showed a less stigmatizing attitude than the male respondents. This gender effect continued after controlling for the subjects' age and family income. In female respondents, parents' level of education and a more positive attitude about treatment of mental illness predicted less stigmatizing attitudes towards mental illness. CONCLUSIONS: The findings suggest that gender difference in this sample has an impact on the stigmatization phenomenon in an independent fashion. A more positive view of female university students towards the mentally ill might be due to their comparatively optimistic attitudes about the treatability of mental illnesses. The observed gender difference seems to be accentuated by the fact that female students' parents' level of education was higher than that of their male counterparts.